Development of chiral nanomaterials and their applications for super-critical fluid chromatography

The current trend in analytical sciences focuses on application of small uniformly sized particles ranging from 1.7-5μm to be used as support materials for chromatographic separation techniques to achieve greater efficiency, lower solvent consumption, lower cost and shorter run time to improve productivity. For this project, we are exploring the application of novel chiral nanomaterials for enantiopurity analyses using SFC technique. The project focuses on the development of applications for nano-sized achiral and chiral packing materials in Super-critical fluid Chromatography (SFC). Judging from the viewpoint of novelty of science, there is to date no known research work published in open literature on the application of chiral-nanomaterials having size ranging 100-1000nm for SFC analyses. The following objectives had been fulfilled for this project, which includes i) the preparation of novel chiral stationary phase of size range 100-1000nm for SFC, ii) the preparation of new chiral and achiral nanomaterials for SFC applications, iii) the development of effective methods for packing SFC columns and iv) demonstrating rapid separations for achiral and chiral compounds using SFC.RG 112/0

Separating materials for chromatography and electrophoresis applications comprising regiodefined functionalised cyclodextrins chemically bonded to a support via urethane functionalities

US6017458Granted Paten

Chemically bonded cationic β-cyclodextrin derivatives and their applications in supercritical fluid chromatography

Cationic β-cyclodextrin (CD) perphenylcarbamoylated derivatives were chemically bonded onto vinylized silica using a radical co-polymerization reaction. The derived materials were used as chiral stationary phases (CSP) in supercritical fluid chromatography (SFC). Enantioseparations were successfully demonstrated on 14 racemates encompassing flavanones, thiazides and amino acid derivatives. The electrostatic force between the analytes and the cationic moiety on β-CD derivative was found to be important for retention and enantioseparation of the racemates. Aromatic cationic moiety on β-CD enabled better enantioseparations than aliphatic cationic moiety. It was also found that the presence of acid additives would result in lower retention of the analytes but often assist the chiral resolutions

Modified Cyclodextrins for Chiral Separation

IX, 258 p. 542 illus.online resource

Saccharide and support for chromatography

US7208086Granted Paten

Materials comprising saccharide cross-linked and chemically bonded to a support via urea linkages

US6720285Granted Paten

Synthesis and characterization of dithienobenzothiadiazole-based donor-acceptor conjugated polymers for organic solar cell applications

New donor–acceptor conjugated polymers (P1 and P2) containing a fused-ring dithienobenzothiadiazole (DT-BTD building block) were synthesized by using the Stille copolymerization method. The synthesized polymers were characterized by 1H NMR, GPC, and elemental analysis. The optical band gaps of the polymers were found to be 1.86 and 1.9 eV, respectively, as calculated from their film onset absorption edge. Upon annealing both produced a distinct shoulder peak in their film absorption spectra. The electrochemical studies of P1 and P2 revealed that the HOMO and LUMO energy levels of the polymer were −5.3, −5.1 eV, and −3.4, −3.2 eV, respectively. The polymers are thermally stable up to 250–350 °C.Accepted versio

Materials comprising saccharide cross-linked and chemically bonded to a support via urea linkages useful for chromatography and electrophoresis applications

US20040154987A1Published Applicatio