A PRECISE STUDY ON “BERBERIS ARISTATA

Indian barberry is a very common plant with miraculous therapeutic activity. This plant was being used from very ancient times. It generally has Habitat of North-western Himalayas, Nilgiris, Kulu, and Kumaon. Propagation of this herb is carried out during the spring season. It is listed in “Ayurveda” for the treatment of various dysenteries. It is well known as “Daruhaldi” in Ayurveda because it is having properties like turmeric. It is also used in different systems of medication like in Ayurveda, Siddha, and Yunani. Twigs are either white or pale yellowish-brown in colour. The bark is having a pale brown appearance on the outside and has deep yellowish colour inside. Leaves are obovate, with reticulated venation, and are arranged in tufts of five to eight. These leaves are having a glossy dark green appearance on the outside and a light green colour inside. Flowers are yellow and are usually bisexual. The fruits are bright red. The stem is subterete, pale brownish yellow. It chiefly contains “berberine” as an active phytoconstituent that belongs to alkaloids. Other than berberine it also contains contain barbamine, oxyberberine, palmatine, and taxilamine. Roots of Berberis aristata contain berberine, barbamine, Jatrorrhizine, columbamine and oxyberberine. This plant is having various therapeutic activities like; antibacterial, antiperiodic, antidiarrheal, antipyretic, antidiabetic, and anticancer activities. Several research works were performed for this plant with the use of systemic animal models. A significant result was obtained. Investigations suggested that it can be used as an antimalarial, antioxidant, anti-inflammatory, hypoglycaemic, and hepatoprotective

Intelligent or Smart Polymers: Advance in Novel Drug Delivery

Novel drug delivery system utilizing smart polymer to get significant and attracting changes in the targeting of drugs, increasing the bioavailability of drugs, enhancement patient compliance  and gene therapy. The scientific community tries to mimic nature in the way that living organisms adopt their behavior as a function of environmental conditions to improve survival. In this sense, smart polymers offer materials that respond to numerous stimuli (temperature, pH, electric and magnetic fields, light intensity, biological molecules, etc.), and scientists must devise the best way to apply them in all research areas. Smart polymers are representing promising means for targeted drug delivery, enhanced drug delivery, gene therapy, actuator stimuli and protein folders. Smart polymers are very promising applicants in drug delivery, tissue engineering, cell culture, gene carriers, textile engineering, oil recovery, radioactive wastage and protein purification. The study is focused on the entire features of smart polymers and their most recent and relevant applications. Keywords: Smart polymer, Novel drug delivery system, Stimuli, Gene therap

Pathways of Targeted Therapy for Colorectal Cancer

One of the most common and deadly cancers in the world, colorectal cancer (CRC) caused around 881,000 melanoma deaths in 2018. The third most frequent cause overall cancer-related death worldwide is colorectal cancer (CRC). A difficult issue related to chemotherapy is the subsequent adverse effects brought on by the toxicity of conventional medications. Location-specific/targeted distribution of chemotherapeutic medicines precisely to the afflicted site of something like the colon in a foreseeable and reliable way is obviously of concern. For many years, cancer sufferers' initial choices have been surgery and chemotherapy. The prognosis for CRC, particularly for those with metastatic tumours, has never been satisfactory. A recent optional strategy called targeted therapy has been effective in extending patients with CRC's overall survival. Following achievements with the anti-EGFR (epidermal growth factor receptor) agent cetuximab and the anti-angiogenesis agent bevacizumab, new drugs that inhibit several important pathways and immune checkpoints are being developed at an unheard-of rate. The growing number of high-quality clinical trials is being used as a basis for updating guidelines worldwide regarding the recommended targeted medications. An overview of current CRC-targeted drugs and their underlying processes is given in this review, along with a discussion of their drawbacks and potential directions. Keywords: Colorectal cancer, Chemotherapeutic medicines, Bevacizumab, Cetuximab