FORMULATION AND EVALUATION OF HERBAL GEL CONTAINING Allium cepa EXTRACT

Herbal medicines widely improved for primary health care because of better cultural acceptability and better compatibility with human body and lesser side effects. The aim of present study was to formulate and evaluate of herbal gel containing Allium cepa extract. Topical gel formulation was designed by using Allium cepa extract and carbopol 934 as a gelling agent and different excipients. The herbaceous plant Allium cepa (onion). It has great health significance and is consumed for nutritional and health benefits for last centuries. It contains flavonoids compound. Plant extract used for prevention of hair loss. Raw onion eaten in salad form this is play very important role in health benefits. Gel was prepared by incorporating extract of Allium cepa in gel at a particular step in order to prepare non greasy formulation. Gel Formulation F3 Batch was optimized in the concentration 1.5% of Carbopol 934. Different gel formulations were evaluated for their physical appearance; pH, Spreadability, Homogeneity in-vitro diffusion ,Viscosity and Drug Excipients comparability study are carried out

Formulation and evaluation of nano-particulate topical gel containing Celecoxib

The present research work describes formulation and evaluation of celecoxib containing gel using transdermal delivery. Transdermal potential of nanoparticulate gel was investigated using in-vitro and in-vivo study. In present study procured drug samples were investigated under preformulation studies. For development of nanparticles containing celecoxib, nanoprecipitation method is used. The formulated nanoparticles were evaluated for different parameters such as zeta potential, particle size, % entrapment efficiency, in-vitro drug release, SEM and stability studies. The formulated nanoparticles were formulated as gel using carbopol. Formulated carbopol gels were characterized for appearance, spreadability, pH, viscosity, drug content, consistency index and ex-vivo drug release, in-vitro drug release. Formulated gels were evaluated for in-vitro studies (skin irritation and skin permeation). Further evaluated for stability studies as per ICH guidelines, results of stability studies reveled that both the formulated gels were found to be stable at stuied temperatures

Formulation and evaluation of carbon nanotubes for topical drug delivery

The carbon nanotubes represent an innovative platform for controlled and targeted drug release in several biomedical applications. Carbon nanotube is one of the most efficient dispersed nano-systems with narrow size distribution ranges from 10-240 nm. Carbon nanotubes possess the remarkable electrical, thermal, mechanical conductivity which enables carbon nanotubes to be functionalized to enhance the solubility as well as biocompatibility of poorly bioavailable drugs. Further it can be converted to normal conventional system which is easy to use such as gel. The purpose of this study is to develop a stable nanotube based gel for topical application of fluconazole (BCS Class-II), having low solubility and high permeability to improve its solubility and hence cutaneous deposition to give local effect. The functionalization of pristine nanotubes was done using PEG-400 initially. Six batches (F1-F6) of drug loaded functionalized nanotubes was prepared using ethanol and water (2:1) which was tested for % drug loading and high drug loaded batch was selected for conversion to gel (NTG1-NTG4) with carbopol 934 and HPMC as gelling agent. Formulations were evaluated for FTIR studies, % drug loading.&nbsp