Simultaneous Scheduling of Machines and AGVs in Flexible Manufacturing System with Minimization of Tardiness Criterion

AbstractOptimum Automated Guided Vehicles (AGVs) operation plays a crucial role in improving the performance of Flexible Manufacturing System (FMS). One of the main elements in the implementation of AGV is task scheduling. This will enhance the productivity, Minimize delivery cost and optimally utilize the entire fleet. This enhance article Deals with Binary particle swarm Vehicle Heuristic Algorithm (BPSVHA) for simultaneous Scheduling of machines and AGVs adopting Rebust factor function and minimization of mean tardiness. The method is found to provide better solutio

Fish hook in classifier efficiency curves: An update

Fish hook in classifier efficiency curves has been receiving attention in the last three decades, more so with the advent of laser diffractometry. In the first part of this paper, we analyse two occurrences of fish hook reported recently in Separation and Purification Technology. It is shown that in both the cases, inaccuracies in measured particle size distributions could be the likely cause of the observed fish hook. In the second part, we re-examine the present state of knowledge on fish hook including the limitations of experimental observations reported so far and the drawbacks of theoretical explanations. Finally, we provide a basis on why it is to be considered nothing more than a scientifically insignificant placebo

Is the fish-hook effect in hydrocyclones a real phenomenon?

Although the fish-hook effect has been reported by many for a very long time, scientists and practitioners alike share contradictory opinions about this phenomenon. While some believe that it is of physical origin, others opine that it is the result of measurement errors. This article investigates the possibility that the fish-hook effect could indeed be measurement error related. Since all the experimental errors are embedded in the raw size distribution measurements, the paper first lays down the steps that lead to estimation of the partition function and confidence bounds, which are seldom reported in hydrocyclone literature, from the errors associated with the experimental size distribution measurements. Using several data sets generated using a 100 mm diameter hydrocyclone operating under controlled dilute to dense regimes, careful analysis of the partition functions following the developed methodology yields unambiguous evidence that the fish-hook effect is a real physical phenomenon. An attempt is also made to reunite some of the major contradictory views behind the existence of the fish-hook based on sound statistical arguments

Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas

© The Author(s) 2019. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Infant gliomas have paradoxical clinical behavior compared to those in children and adults: low-grade tumors have a higher mortality rate, while high-grade tumors have a better outcome. However, we have little understanding of their biology and therefore cannot explain this behavior nor what constitutes optimal clinical management. Here we report a comprehensive genetic analysis of an international cohort of clinically annotated infant gliomas, revealing 3 clinical subgroups. Group 1 tumors arise in the cerebral hemispheres and harbor alterations in the receptor tyrosine kinases ALK, ROS1, NTRK and MET. These are typically single-events and confer an intermediate outcome. Groups 2 and 3 gliomas harbor RAS/MAPK pathway mutations and arise in the hemispheres and midline, respectively. Group 2 tumors have excellent long-term survival, while group 3 tumors progress rapidly and do not respond well to chemoradiation. We conclude that infant gliomas comprise 3 subgroups, justifying the need for specialized therapeutic strategies.info:eu-repo/semantics/publishedVersio

Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations

Tumors with histological features of pilocytic astrocytoma (PA), but with increased mitotic activity and additional high-grade features (particularly microvascular proliferation and palisading necrosis) have often been designated anaplastic pilocytic astrocytomas. The status of these tumors as a separate entity has not yet been conclusively demonstrated and molecular features have only been partially characterized. We performed DNA methylation profiling of 102 histologically defined anaplastic pilocytic astrocytomas. T-distributed stochastic neighbor-embedding (t-SNE) and hierarchical clustering analysis of these 102 cases against 158 reference cases from 12 glioma reference classes revealed that a subset of 83 of these tumors share a common DNA methylation profile that is distinct from the reference classes. These 83 tumors were thus denominated DNA methylation class anaplastic astrocytoma with piloid features (MC AAP). The 19 remaining tumors were distributed amongst the reference classes, with additional testing confirming the molecular diagnosis in most cases. Median age of patients with MC AAP was 41.5 years. The most frequent localization was the posterior fossa (74%). Deletions of CDKN2A/B (66/83, 80%), MAPK pathway gene alterations (49/65, 75%, most frequently affecting NF1, followed by BRAF and FGFR1) and mutations of ATRX or loss of ATRX expression (33/74, 45%) were the most common molecular alterations. All tumors were IDH1/2 wildtype. The MGMT promoter was methylated in 38/83 tumors (45%). Outcome analysis confirmed an unfavorable clinical course in comparison to PA, but better than IDH wildtype glioblastoma. In conclusion, we show that a subset of histologically defined anaplastic pilocytic astrocytomas forms a separate DNA methylation cluster, harbors recurrent alterations in MAPK pathway genes in combination with alterations of CDKN2A/B and ATRX, affects patients who are on average older than those diagnosed with PA and has an intermediate clinical outcome

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