16 research outputs found
Effects of human land use on the terrestrial and aquatic sources of fluvial organic matter in a temperate river basin (The Meuse River, Belgium)
Full text linkAn exploratory study of benthic diatom communities in stormwater ponds of different land uses and varying biocide contamination
Full text linkThe NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation
Full text linkImmune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is restricted and there is a need to identify new therapeutic targets. Here, we show that natural killer cell granule protein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broad range of diseases. NKG7 expressed by CD4+\ua0and CD8+\ua0T cells played key roles in promoting inflammation during visceral leishmaniasis and malaria—two important parasitic diseases. Additionally, NKG7 expressed by natural killer cells was critical for controlling cancer initiation, growth and metastasis. NKG7 function in natural killer and CD8+\ua0T cells was linked with their ability to regulate the translocation of CD107a to the cell surface and kill cellular targets, while NKG7 also had a major impact on CD4+\ua0T cell activation following infection. Thus, we report a novel therapeutic target expressed on a range of immune cells with functions in different immune responses
In situ quantification of CH4 bubbling events from a peat soil using a new infrared laser spectrometer
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The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation
Full text linkImmune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is restricted and there is a need to identify new therapeutic targets. Here, we show that natural killer cell granule protein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broad range of diseases. NKG7 expressed by CD4+ and CD8+ T cells played key roles in promoting inflammation during visceral leishmaniasis and malaria—two important parasitic diseases. Additionally, NKG7 expressed by natural killer cells was critical for controlling cancer initiation, growth and metastasis. NKG7 function in natural killer and CD8+ T cells was linked with their ability to regulate the translocation of CD107a to the cell surface and kill cellular targets, while NKG7 also had a major impact on CD4+ T cell activation following infection. Thus, we report a novel therapeutic target expressed on a range of immune cells with functions in different immune responses
Sensitivity Analysis and Calibration of a Rainfall-Runoff Model with the Combined Use of EPA-SWMM and Genetic Algorithm
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Métodos de diagnóstico não-invasivos para avaliação da insuficiência venosa dos membros inferiores
Full text linkSpatially-integrated estimates of net ecosystem exchange and methane fluxes from Canadian peatlands
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