Renal cell cancer without a renal primary

Renal cell carcinoma has been increasing in incidence over the past two decades. Men are affected more than women and metastatic disease at presentation occurs in up to one third of patients. Metastasis can occur to virtually any organ, and involvement of multiple organs is not uncommon. To date, no reports have been found of metastatic disease without a renal primary. We present a case of renal cell cancer initially presenting as a subcutaneous mass with subsequent pancreatic and parotid gland metastases in absence of a primary renal source

Isolation and characterization of a new species of Neisseria, Neisseria musculi, from the wild house mouse

Neisseria have been isolated from or detected in a wide range of animals, from nonhuman primates and felids to a rodent, the guinea pig (Liu et al., 2015). By means of selective culture, biochemical testing, Gram staining and PCR screening for the Neisseria-specific Internal Transcribed Spacer region of the rRNA operon, we isolated four strains of Neisseria from the oral cavity of the wild house mouse, Mus musculus subspecies domesticus. The isolates are highly related and form a separate clade in the genus, as judged by rMLST and core gene tree analyses. One isolate, provisionally named Neisseria musculi sp. nov. (type strain AP2031T = DSM 101846T = CCUG 68283T = LMG 29261T), was studied further. AP2031/N. musculi grows well in vitro. It is naturally competent, taking up DNA in a DUS and pilT-dependent manner, and is amenable to genetic manipulation. These and other genomic attributes of N. musculi make it an ideal candidate for use in developing a mouse model for studying Neisseria-host interactions

Isolation and characterization of Neisseria musculi sp. nov., from the wild house mouse

Neisseria have been isolated from or detected in a wide range of animals, from nonhuman primates and felids to a rodent, the guinea pig (Liu et al., 2015). By means of selective culture, biochemical testing, Gram staining and PCR screening for the Neisseria-specific Internal Transcribed Spacer region of the rRNA operon, we isolated four strains of Neisseria from the oral cavity of the wild house mouse, Mus musculus subspecies domesticus. The isolates are highly related and form a separate clade in the genus, as judged by rMLST and core gene tree analyses. One isolate, provisionally named Neisseria musculi sp. nov. (type strain AP2031T = DSM 101846T = CCUG 68283T = LMG 29261T), was studied further. AP2031/N. musculi grows well in vitro. It is naturally competent, taking up DNA in a DUS and pilT-dependent manner, and is amenable to genetic manipulation. These and other genomic attributes of N. musculi make it an ideal candidate for use in developing a mouse model for studying Neisseria-host interactions

Isolation and characterization of Neisseria musculi sp. nov., from the wild house mouse

Neisseria have been isolated from or detected in a wide range of animals, from nonhuman primates and felids to a rodent, the guinea pig (Liu et al., 2015). By means of selective culture, biochemical testing, Gram staining and PCR screening for the Neisseria-specific Internal Transcribed Spacer region of the rRNA operon, we isolated four strains of Neisseria from the oral cavity of the wild house mouse, Mus musculus subspecies domesticus. The isolates are highly related and form a separate clade in the genus, as judged by rMLST and core gene tree analyses. One isolate, provisionally named Neisseria musculi sp. nov. (type strain AP2031T = DSM 101846T = CCUG 68283T = LMG 29261T), was studied further. AP2031/N. musculi grows well in vitro. It is naturally competent, taking up DNA in a DUS and pilT-dependent manner, and is amenable to genetic manipulation. These and other genomic attributes of N. musculi make it an ideal candidate for use in developing a mouse model for studying Neisseria-host interactions