THE EFFICIENCY OF STUDENTS' RESEARCH ACTIVITIES AT THE FOOD PRODUCTION UNIVERSITY

In recent years the ongoing modernization of higher education in Russia in the context of continuous food production education provides an opportunity for learners to improve their professional knowledge and skills throughout their lives. Continuous education is carried out through: a) the development of educational programs in organizations that carry out educational activities, b) training in the framework of professional non-profit organizations, c) individual cognitive activities. From this perspective, the educational process in a food production university should be a synthesis of education, training, production practice and research work. The framework of the students' research activities allows students to get acquainted with the topical scientific and technological achievements at scientific conferences, research laboratories and workshops of technological enterprises. The implementation of the Bologna Agreement on the territory of the Russian Federation is aimed at training competitive, initiative, and creative specialists, who are ready for continuous professional growth. This challenge can be solved by conceptual revision of the educational process with the transition from the pre-existing training in the form of passive perception by the student of ready knowledge provided by the teacher to the educational process in the form of active knowledge acquisition by students. The purpose of this article is to analyze the organization and efficiency of educational and research work of students of the Moscow State University of Food Production. The efficiency of students' research activities is complex and includes the following indicators to be measured and quantified: the efficiency of the mass coverage of students; the efficiency of the impact of research activities on the development of creative abilities and mastering the methods of individual and collective creativity; the efficiency of quality content and contribution of students in science; the efficiency of the subject influence onto the object of the process of forming qualities, skills; efficiency of methods, forms and means for the process of forming the subject of creativity. Identification of the efficiency and prospects of 118 students' research activities at the Moscow State University of Food Production (their mean age is 18-19 years) was carried out by method of a survey, as well as using Pareto diagram and Ishikawa diagram. The results showed that students, who are actively and productively engaged in research activities, mostly have professional skills and competencies related to the practical use of the knowledge, skills and potentials than their colleagues not involved in research work. Professional competence of the future specialists is the ability to successfully act on the basis of knowledge in solving problems of the professional kind, and also determines the social significance of the future specialists, their mobility and readiness for innovative professional activity, which becomes possible with the active participation of students in research activities. Thus, the results of the analysis of the efficiency of students' research work identified the vector of further development and formation improvement of research that should increase the interest and motivation of students to conduct experimental and theoretical studies with the skills of independent theoretical and practical work in the food production industry

Intraovarian autoplasmotherapy in patients with diminished ovarian reserve

Objective. To evaluate the efficacy of Intraovarian autoplasmotherapy (platelet-rich plasma/PRP) in the activation of ovarian function in patients with diminished ovarian reserve and “poor” response in the in vitro fertilization (IVF) cycles, as well as its influence on the quality of life. Patients and methods. A total of 120 patients with diminished ovarian reserve and a history of IVF cycle failure who refused to use donor oocytes were included in the study. All patients underwent intraovarian PRP therapy based on the proprietary technology. The quality of life, the ovarian function, and the results of the embryo stage in the IVF cycle were monitored for 6 months. Results. The conducted study demonstrates a positive effect of intraovarian PRP therapy on the functional state of the ovaries and on the results of the embryo stage in IVF in the cohort of patients with diminished ovarian reserve and “poor” response in previous unsuccessful IVF cycles. The findings also indicate changes in the quality of life, an improvement in sexual function, and positive dynamics in the emotional state. Conclusion. Intraovarian PRP therapy allows patients with infertility and diminished ovarian reserve to avoid using donor oocytes and to obtain their own genetic material. This technology has a positive effect on the quality of life, having a certain anti-age effect in all groups of examined women, the duration of which has yet to be clarified. © 2021, Dynasty Publishing House. All rights reserved

CURRENT POSSIBILITIES OF NONHORMONAL OVARIAN FUNCTION ACTIVATION WITH LOW OVARIAN RESERVE

Patients with low ovarian reserve occupy a significant place in the pattern of an infertile marriage. Ovarian reserve is a clinical phenomenon caused by age, genetics, autoimmune mechanisms, and environmental factors. This term is used to describe the reproductive potential and to predict a response to controlled ovulation stimulation in assisted reproductive technology programs. According to a variety of data, the prevalence of low ovarian reserve varies from 5.6 to 35.1%. To date, little is known about the causes of diminished ovarian reserve and its risk factors except the iatrogenic factors associated with surgical intervention. From the clinical point of view, the low ovarian reserve group includes female patients with a poor ovarian response, those with premature ovarian failure, and late reproductive-aged women. Current strategies for controlled ovarian stimulation focus on growing follicles; in this case, dormant primordial follicles cannot be activated by the currently known stimulation protocols. The most successful outcome in patients with a poor response or ovarian insufficiency is pregnancy achieved using donor oocytes, but a large majority of the women think badly of these programs and are looking for alternative solutions. The literature review presents an update on the possibilities, features, and side effects of technologies for nonhormonal ovarian function activation with low ovarian reserve: autologous intraovarian platelet rich plasma (PRP) therapy, stem cell injections, and surgical ovarian activation. Conclusion: Heterogeneity in study designs and data analysis does not yet allow the effectiveness of the technologies under consideration to be evaluated. For none of them, the exact mechanisms of action are still unknown. However, in our opinion, intraovarian PRP injection is the safest and most effective therapy. At the same time, the features of the technology and its effectiveness in various patient cohorts require further careful study. © A group of authors, 2022