СТЕПЕНЬ АЛЬТЕРАЦИИ NMDAИ AMPA-РЕЦЕПТОРОВ ГЛУТАМАТА В ПАТОГЕНЕЗЕ ЗАБОЛЕВАНИЯ И ТЕХНОЛОГИЧЕСКИЕ ОСОБЕННОСТИ ХИРУРГИЧЕСКОГО ЛЕЧЕНИЯ ГЛИОМ ПОЛУШАРИЙ БОЛЬШОГО МОЗГА, ТЕКУЩИХ С ЭПИЛЕПТИЧЕСКИМ СИНДРОМОМ

The development of effective approaches to the treatment of patients with symptomatic tumor epilepsy was determined by the level of our fundamental knowledge of the basic mechanisms of epileptogenesis on cellular and molecular level. 92 patients with gliomas of the cerebral hemisphereswere examined. Immunoenzyme method ofsemiquantitative determination of the level of autoantibodies to NR2A subunit of NMDA and GluR1 subunit of AMPA receptors of glutamate was used. The reaction of NMDA and AMPA glutamate receptors depending on the availability of an epileptic syndrome in the clinical picture of the disease and the extent of radical surgery has been studied. Pre-emptive increase of the level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate in patients with hemispheric gliomaswith epileptic syndrome was demonstrated. It was foundonly the total removal of the tumor reduced significantly the level of autoantibodies to ionotropic glutamate receptors.Разработка эффективных подходов к лечению больных с симптоматической опухолевой эпилепсией определяется уровнем наших фундаментальных знаний основных механизмов эпилептогенеза на клеточно-молекулярном уровне. Обследованы 92 больных с глиомами полушарий большого мозга. Использован ретроспективный иммуноферментный метод полуколичественного определения уровня аутоантител к NR2A-субъединице NMDA- и GluR1-субъединице AMPA-рецепторов глутамата. Изучена реакция NMDA- и AMPA-рецепторов глутамата в зависимости от наличия эпилептического синдрома в клинической картине заболевания и степени радикальности хирургического вмешательства. Показано преимущественное повышение уровня аутоантител к GluR1-субъединице AMPA-рецепторов глутамата у больных глиомами, текущими с эпилептическим синдромом. Установлено, что уровень аутоантител к ионотропным глутаматным рецепторам значимо снижается только при тотальном удалении опухоли

Students virtual and social identity in the process of humanities study: The problems of its correction

© 2016, Econjournals. All rights reserved.The relevance of the research problem is reasoned by global use of Internet technologies, altering the forms of personal self-identification: Atransition of the external world and human individuality in a digital code, the creation of informational imprint in space of the worldwide web, the alienation of the student youth in society, the substitution of reality by virtual world. In this direction a significant potential belongs to humanities, studying of which contributes to the interpenetration and mutual reinforcement of students’ social and virtual identification based on universal norms, values, value orientations, correction of virtual identity redundancy in real society. This article is aimed at scientifically-methodical substantiation of structure and content of pedagogical correction of higher school students’ self-identification in the process of humanities’ study. The leading method in this problem study is a method of modeling of the structure and content of students’ self-identification pedagogical correction in the process of humanitarian disciplines’ study. The article presents the theoretical and methodological foundations of the design and implementation of student’s social and virtual identity correction’s model, its discursive content and mechanisms, structure and new forms’ content in the process of humanities’ study. The presented materials in the article contribute to evidence-based correction of students virtual and social identity in the process of humanities’ study and are recommended to use for teachers, methodologists, university information departments’ programmers, improvement of qualification and teacher retraining courses’ attendants

POSSIBLE WAYS TO INCREASE EFFECTIVENESS OF REPERFUSION THERAPY

Possible ways to increase effectiveness of reperfusion therapy

Heart rate variability and trans-esophageal atrial stimulation data in predicting recurrent atrial fibrillation paroxysms

In 34 women with stable coronary heart disease (CHD), heart rate variability (ИВУ) and trans-esophageal atrial stimulation parameters were examined after the first atrial fibrillation (AF) paroxysm. Prognostic value of these parameters in recurrent AF paroxysm risk assessment was investigated. In patients with recurrent AF paroxysm developed in the next 6 months (Group 1), HRV parameters were significantly increased, and AF paroxysm >15 s was induced by trans-esophageal stimulation in 50% of the subjects. In Group 2 (sinus rhythm lasting for 6 months), this rate was 14,3% only. HRV parameters and AF paroxysm induction in trans-esophageal stimulation could be used for recurrent AF paroxysm risk assessment

Heart rate variability and trans-esophageal atrial stimulation data in predicting recurrent atrial fibrillation paroxysms

In 34 women with stable coronary heart disease (CHD), heart rate variability (HVR) and trans-esophageal atrial stimulation parameters were examined after the first atrial fibrillation (AF) paroxysm. Prognostic value of these parameters in recurrent AFparoxysm risk assessment was investigated. In patients with recurrent AF paroxysm developed in the next 6 months (Group 1), HRV parameters were significantly increased, and AF paroxysm >15 s was induced by trans-esophageal stimulation in 50 % of the subjects. In Group 2 (sinus rhythm lasting for 6 months), this rate was 14, 3 % only. HRV parameters and AF paroxysm induction in trans-esophageal stimulation could be used for recurrent AF paroxysm risk assessment

Comparison of antianginal and antiischemic efficacy of cytoprotectors, nitrates, and beta-blockers during monotherapy and combined therapy in patients with effort angina and silent myocardial ischemia episodes

In 57 patients with stable effort angina, functional class II-III, and episodes of silent myocardial ischemia, antianginal and antiischemic efficacy of trimetazidine, isosorbide-5-mononitrate, and nadolol (monotherapy and combined therapy) was compared. According to the results obtained, trimetazidine had sufficiently high efficacy and safety. Nevertheless, antiischemic efficacy of nadolol was higher than that for isosorbide-5-mononitrate and trimetazidine. Combination of trimetazidine and hemodynamically active preparations did enhance antiischemic action, without adverse circulatory effects. This additive effect was maximal for trimetazidine and nadolol combination