Immunocytochemical localisation of follicle stimulating hormone (FSH) in normal, benign and malignant human prostates.

Immunocytochemical localisation of follicle stimulating hormone (FSH) was carried out in normal, benign and malignant human prostates by indirect immunoperoxidase technique. Positive staining was observed in the epithelial cells of all the three categories, while the stromal cells showed a weakly positive reaction in a few specimens. The brown reaction product was dispersed in the cytoplasm of the epithelial cells. These observations demonstrate the presence of immunoreactive FSH-like peptide in human prostate. The significance of FSH in the aetiopathology of prostatic disorders is discussed

Studies on immunocytochemical localization of inhibin-like material in human prostatic tissue: comparison of its distribution in normal, benign and malignant prostates.

A specific antiserum has been generated against inhibin-like material (ILM) of prostatic origin. Using the immunoperoxidase technique, localization of ILM has been examined in a total of 114 prostates including normal (4 specimens), malignant (46) and hyperplastic (55) tissues. ILM positive immunocytochemical reactions were confined to the cytoplasm and not the nucleus of the prostatic acinar cells in the three categories of prostate, whereas the stroma showed negative reactions. The intensity of positive reactions decreased in the following order: Hyperplasia, incidental and moderately differentiated carcinomas, poorly differentiated carcinomas, whereas metaplasia and granulomatous prostatitis gave negative reactions for ILM. Using this experimental protocol, 200 non-prostatic tissue were found to be completely negative, demonstrating the specificity of the test for prostatic epithelium. These findings indicate a potential use of ILM as a marker of prostatic tissue

An excursion set model of the cosmic web: The abundance of sheets, filaments and halos

We discuss an analytic approach for modeling structure formation in sheets, filaments and knots. This is accomplished by combining models of triaxial collapse with the excursion set approach: sheets are defined as objects which have collapsed along only one axis, filaments have collapsed along two axes, and halos are objects in which triaxial collapse is complete. In the simplest version of this approach, which we develop here, large scale structure shows a clear hierarchy of morphologies: the mass in large-scale sheets is partitioned up among lower mass filaments, which themselves are made-up of still lower mass halos. Our approach provides analytic estimates of the mass fraction in sheets, filaments and halos, and its evolution, for any background cosmological model and any initial fluctuation spectrum. In the currently popular $\Lambda$CDM model, our analysis suggests that more than 99% of the cosmic mass is in sheets, and 72% in filaments, with mass larger than $10^{10} M_{\odot}$ at the present time. For halos, this number is only 46%. Our approach also provides analytic estimates of how halo abundances at any given time correlate with the morphology of the surrounding large-scale structure, and how halo evolution correlates with the morphology of large scale structure.Comment: 22 pages, 7 figures, Accepted for publication in Ap

Power law correlations in galaxy distribution and finite volume effects from the Sloan Digital Sky Survey Data Release Four

We discuss the estimation of galaxy correlation properties in several volume limited samples, in different sky regions, obtained from the Fourth Data Release of the Sloan Digital Sky Survey. The small scale properties are characterized through the determination of the nearest neighbor probability distribution. By using a very conservative statistical analysis, in the range of scales [0.5,~30] Mpc/h we detect power-law correlations in the conditional density in redshift space, with an exponent \gamma=1.0 \pm 0.1. This behavior is stable in all different samples we considered thus it does not depend on galaxy luminosity. In the range of scales [~30,~100] Mpc/h we find evidences for systematic unaveraged fluctuations and we discuss in detail the problems induced by finite volume effects on the determination of the conditional density. We conclude that in such range of scales there is an evidence for a smaller power-law index of the conditional density. However we cannot distinguish between two possibilities: (i) that a crossover to homogeneity (corresponding to \gamma=0 in the conditional density) occurs before 100 Mpc/h, (ii) that correlations extend to scales of order 100 Mpc/h (with a smaller exponent 0 < \gamma <1). We emphasize that galaxy distributions in these samples present large fluctuations at the largest scales probed, corresponding to the presence of large scale structures extending up to the boundaries of the present survey. Finally we discuss several differences between the behavior of the conditional density in mock galaxy catalogs built from cosmological N-body simulations and real data. We discuss some theoretical implications of such a fact considering also the super-homogeneous features of primordial density fields.Comment: 13 pages, 19 figures, to be publsihed in Astronomy and Astrophysic

On Local Approximations to the Nonlinear Evolution of Large-Scale Structure

We present a comparative analysis of several methods, known as local Lagrangian approximations, which are aimed to the description of the nonlinear evolution of large-scale structure. We have investigated various aspects of these approximations, such as the evolution of a homogeneous ellipsoid, collapse time as a function of initial conditions, and asymptotic behavior. As one of the common features of the local approximations, we found that the calculated collapse time decreases asymptotically with the inverse of the initial shear. Using these approximations, we have computed the cosmological mass function, finding reasonable agreement with N-body simulations and the Press-Schechter formula.Comment: revised version with color figures, minor changes, accepted for publication in the Astrophysical Journal, 30 pages, 13 figure