ОЦЕНКА ОБРАЗЦОВ ФАСОЛИ ОВОЩНОЙ ПО ПРОДУКТИВНОСТИ БОБОВ И КЛУБЕНЬКООБРАЗУЮЩЕЙ СПОСОБНОСТИ В УСЛОВИЯХ ЛЕСОСТЕПИ ПРИОБЬЯ

The efficiency of root formation capacity of the bean hybrids in the conditions of forest,steppe  of the Ob region has been shown.Показана эффективность клубенькообразующей способности гибридных образцов фасоли овощной в условиях лесостепи Приобья

A relationship between causative agents of infectious diarrhea and fatal outcomes in pre-school children

Infectious diarrhea is one of the leading causes of fatal outcomes in young children. Differential diagnostics of such infections within the first hours of illness poses significant objective obstacles. Data from laboratory studies of autopsy material and pathological studies provide valuable information for understanding the spectrum of differential diagnostics and etiological structure of infectious diarrhea with fatal outcomes in young children. Materials and methods. There were analyzed 100 cases of fatal outcomes in children under the age of six years registered in Russia from November 2011 to December 2019, who was diagnosed with infectious diarrhea at different levels of the healthcare system. The data were assessed based on available medical case reports and the laboratory testing of autopsy samples performed by using nucleic acid amplification methods. Results. The diagnosis of infectious diarrhea was revised in 24 patients, based on the data of a set of intravital and post-mortem studies. In patients with unconfirmed diagnosis of acute intestinal infections, pneumonia was the most often detected — in 45.8% (11/24), sepsis — in 29.2% (7/24), meningitis/meningoencephalitis, acute surgical pathology and asphyxiation associated with vomit aspiration — in 16.7 % (4/24) cases. The causative agents of infectious diarrhea were identified in 71 of 76 patients with confirmed diagnosis of acute intestinal infections. Most prevalent were group A rotaviruses — 52.6% (40/76), group F adenoviruses — 17.1% (13/76), and noroviruses — 13.2% (10/76). Combination of pathogens was detected in 29 cases (38.2%). Prehospital lethal outcomes in patients with infectious diarrhea were observed in 17 cases (22.4%). In total, rate of neonatal deaths due to acute intestinal infections accounted for 62.2% and 2-year-old toddlers — 20.3%. 64 of 76 (84%) children had no unfavorable premorbid background. The most common pathologies associated with infectious diarrhea with developing fatal outcomes were pneumonia (including aspiration pneumonia) in 22.4% (17/76) and aspiration asphyxia in 6.6% (5/76). Hemolytic-uremic syndrome associated with diarrhea was diagnosed in 7.9% (6/76) of children. Conclusions. Within the first years of life children comprise a risk group for developing fatal outcomes during infectious diarrhea. Lack of unfavorable premorbid background should not be considered as a reliable positive prognostic criterion. Diagnostics of pneumonia should be included in the mandatory examination plan for children with severe infectious diar rhea. Based on study of clinical and autopsy material, group A rotaviruses were the lead causative agents among those resulting in infectious diarrhea with fatal outcomes in young children. Special attention should be paid to preventing vomit aspiration within the first days after disease onset

ОЦЕНКА ЭПИДЕМИОЛОГИЧЕСКИХ ЭФФЕКТОВ ПРИМЕНЕНИЯ ПЯТИВАЛЕНТНОЙ РОТАВИРУСНОЙ ВАКЦИНЫ ПРИ НИЗКОМ УРОВНЕ ОХВАТА ВАКЦИНАЦИЕЙ ЦЕЛЕВОЙ КОГОРТЫ

Background: Assessment of the informativeness of using various parameters characterizing the epidemic process during rotavirus infection to analyze the effects of the RotaTeq (MSD, USA) pentavalent rotavirus vaccine’s using at low (<20%) level of vaccination coverage of the target cohort. Materials and methods: Were analyzed the correlation links between the vaccination coverage rates and the number of reported cases of rotavirus infection, incidence rates, the number of rotavirus-positive laboratory tests and their shares among the examined children for the territories of Moscow and the Moscow Region in 2014-2018, using the database of the laboratory information system and data of the Federal statistical monitoring, Results: The presence of a strong reliable inverse correlation between the coverage of vaccination and the only of the analyzed indicators – the share of positive results of laboratory studies in the age group of children 6-24 months was revealed. There was a one and a half to two-fold decrease in the share of positive laboratory tests for rotavirus infection in the years of reaching 18–20% vaccination coverage. Conclusion: The obtained data indicate the high informative value of laboratory information system data and the perspective of their use for a comprehensive assessment of the activity of the epidemic process.Цель: оценка информативности использования различных параметров, характеризующих эпидемический процесс при ротавирусной инфекции, для оценки эффектов применения пятивалентной ротавирусной вакцины РотаTек (MSD, США) при низком (<20%) уровне охвата вакцинацией целевой когорты. Материалы и методы: с использованием базы данных лабораторной информационной системы и данных  едерального статистического наблюдения были проанализированы корреляционные связи уровней охвата вакцинацией с количеством регистрируемых случаев ротавирусной инфекции, показателями заболеваемости, количеством положительных результатов лабораторных исследований на ротавирусы и их долей среди обследованных детей для территорий Москвы и Московской области в 2014–2018 гг. Результаты: выявлено наличие сильной достоверной обратной корреляционной связи между охватом вакцинацией и единственным из проанализированных показателей – долей положительных результатов лабораторных исследований в возрастной группе детей 6–24 мес. В годы достижения 18–20% охвата вакцинацией наблюдалось 1,5–2-кратное снижение доли положительных лабораторных исследований на ротавирусную инфекцию. Заключение: полученные данные свидетельствуют о высокой информативной ценности данных лабораторной информационной системы и перспективности их использования для комплексной оценки активности эпидемического процесса

EVALUATION OF BEAN VEGETABLE SAMPLES ON PRODUCQ TIVITY AND ROOT FORMATION CAPACITY IN THE CONDIQ TIONS OF FORESTQSTEPPE OF THE OB REGION

The efficiency of root formation capacity of the bean hybrids in the conditions of forest,steppe  of the Ob region has been shown

Assessment of the epidemiological effects of using of the pentavalent rotavirus vaccine at a low level of vaccination coverage of the target cohort

Background: Assessment of the informativeness of using various parameters characterizing the epidemic process during rotavirus infection to analyze the effects of the RotaTeq (MSD, USA) pentavalent rotavirus vaccine’s using at low (<20%) level of vaccination coverage of the target cohort. Materials and methods: Were analyzed the correlation links between the vaccination coverage rates and the number of reported cases of rotavirus infection, incidence rates, the number of rotavirus-positive laboratory tests and their shares among the examined children for the territories of Moscow and the Moscow Region in 2014-2018, using the database of the laboratory information system and data of the Federal statistical monitoring, Results: The presence of a strong reliable inverse correlation between the coverage of vaccination and the only of the analyzed indicators – the share of positive results of laboratory studies in the age group of children 6-24 months was revealed. There was a one and a half to two-fold decrease in the share of positive laboratory tests for rotavirus infection in the years of reaching 18–20% vaccination coverage. Conclusion: The obtained data indicate the high informative value of laboratory information system data and the perspective of their use for a comprehensive assessment of the activity of the epidemic process