Bio-signals compression using auto-encoder

Latest developments in wearable devices permits un-damageable and cheapest way for gathering of medical data such as bio-signals like ECG, Respiration, Blood pressure etc. Gathering and analysis of various biomarkers are considered to provide anticipatory healthcare through customized applications for medical purpose. Wearable devices will rely on size, resources and battery capacity; we need a novel algorithm to robustly control memory and the energy of the device. The rapid growth of the technology has led to numerous auto encoders that guarantee the results by extracting feature selection from time and frequency domain in an efficient way. The main aim is to train the hidden layer to reconstruct the data similar to that of input. In the previous works, to accomplish the compression all features were needed but in our proposed framework bio-signals compression using auto-encoder (BCAE) will perform task by taking only important features and compress it. By doing this it can reduce power consumption at the source end and hence increases battery life. The performance of the result comparison is done for the 3 parameters compression ratio, reconstruction error and power consumption. Our proposed work outperforms with respect to the SURF method

One Pot Synthesis of Acridine Analogues from 1,2-Diols as Key Reagents

Lead tetraacetate have been demonstrated to be efficient, low cost and mild reagents for the one pot synthesis of acridine derivatives from a variety of 1,2-diols. 1,2-Diols are oxidised in situ to aldehydes, which in turn undergo reaction with dimedone and ammonium acetate to yield acridine derivatives. The attractive features of this process are mild reaction conditions, short reaction times, broad functional group tolerance, easy isolation of products and excellent yields. Thus, the current method utilises 1,2-diols instead of benzaldehydes to synthesise acridines derivatives

One-Pot Synthesis of 2,4,5-Triphenyl Imidazoles from 1,2-Diols as Key Reagents

A simple one-pot procedure for the preparation of 2,4,5-triphenyl imidazole derivatives is presented. The procedure involves the lead tetraacetate oxidation of 1,2-diols to give aldehydes in situ, which then undergo a three-component reaction with benzil and ammonium acetate to yield the imidazole derivatives. © 2017 The Chemical Society Located in Taipei & Wiley-VCH Verlag GmbH & Co. KGaA, Weinhei

Assessment of subjective outcomes in women after treatment of lower urinary tract symptoms

Background: Lower urinary tract symptoms (LUTS) are the most common symptoms in women at all age groups worldwide. Their overall prevalence among women is 67%, and incidence increases with age. To assess the impact of LUTS comprehensively, it is therefore necessary to measure both the level of an individual’s symptoms and the extent to which they impair their life. This is particularly important when making a decision as to whether an individual is likely to require or benefit from treatment, and in evaluating the effectiveness of such treatment. Aim and objectives were to assess the subjective outcomes in women following treatment of lower urinary tract symptoms using King’s health questionnaire (KHQ).Methods: This study was carried out in 106 women presenting with LUTS at Ramaiah Medical College and Hospital as per the inclusion and exclusion criteria from November 2017 to June 2019. KHQ was used to assess subjective outcomes pre-treatment and 3 months post-treatment. Statistical analysis was done using the statistical software namely IBM statistical package for the social sciences (SPSS) statistics version 22.Results: There was significant improvement in all the domains of KHQ indicating that patients had a better quality of life (QoL) post treatment. The mean total KHQ score decreased from a maximum of 40.14 at the pre-treatment time point to a minimum of 12.25 at the post treatment time point. This change was statistically significant. 90.6% of the participants had subjective improvement following treatment of LUTS. 9.4% of the participants reported no improvement in quality of life QoL following treatment of LUTS.Conclusions: This study shows the value of KHQ as an evaluation tool to determine the subjective outcome in women following treatment of LUTS. There was significant improvement in all the domains of KHQ between the two time points in our study indicating a better QoL following the treatment given with subjective improvement of 90.6%.

Biosynthesis, Partial Characterization and Antimicrobial Activities of Silver Nanoparticles from Pleurotus Species

Integration of microorganisms to nanotechnology is one of the key issues in nanoscience research. There is growing need to develop environmentally benign metal nanoparticle synthesis process that do not use toxic chemicals in the synthesis protocols to avoid adverse effects in medical applications. The use of microorganisms in the synthesis of nanoparticles emerges as an eco-friendly approach. In the present study, biosynthesis of silver nanoparticles using edible mushrooms Viz., Pleurotus pulmonarius, Pleurotus djamor and Hypsizygus (pleurotus)ulmarius, partial characterization of silver nanoparticle and its antimicrobial study have been reported. It was found that the aqueous silver ions of 1-5mM concentration were reduced to silver metal nanoparticles by nitrate dependent reeducate and a shuttle quinone extracellular process when treated with fungal supernatant of Pleurotus pulmonarius, in 24hrs(2mM); Pleurotus djamor in 48hrs(5mM) and Hypsizygus ulmarius in 48hrs(3mM). Partial characterization of synthesized silver nanoparticles, investigated by UV-VIS Spectroscopy showed increased productivity at 386nm with sharp and intense surface plasmon. It is found that silver nanoparticles are bound to protein through carboxylate group of aminoacid residues. The synthesized silver nanoparticle showed high bactericidal activity against Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) bacteria . The mechanism of the Ag NP bactericidal activity is discussed in terms of Ag NP interaction with the cell membranes of bacteria

Biosynthesis, Partial Characterization and Antimicrobial Activities of Silver Nanoparticles from Pleurotus Species

Integration of microorganisms to nanotechnology is one of the key issues in nanoscience research. There is growing need to develop environmentally benign metal nanoparticle synthesis process that do not use toxic chemicals in the synthesis protocols to avoid adverse effects in medical applications. The use of microorganisms in the synthesis of nanoparticles emerges as an eco-friendly approach. In the present study, biosynthesis of silver nanoparticles using edible mushrooms Viz., Pleurotus pulmonarius, Pleurotus djamor and Hypsizygus (pleurotus)ulmarius, partial characterization of silver nanoparticle and its antimicrobial study have been reported. It was found that the aqueous silver ions of 1-5mM concentration were reduced to silver metal nanoparticles by nitrate dependent reeducate and a shuttle quinone extracellular process when treated with fungal supernatant of Pleurotus pulmonarius, in 24hrs(2mM); Pleurotus djamor in 48hrs(5mM) and Hypsizygus ulmarius in 48hrs(3mM). Partial characterization of synthesized silver nanoparticles, investigated by UV-VIS Spectroscopy showed increased productivity at 386nm with sharp and intense surface plasmon. It is found that silver nanoparticles are bound to protein through carboxylate group of aminoacid residues. The synthesized silver nanoparticle showed high bactericidal activity against Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) bacteria . The mechanism of the Ag NP bactericidal activity is discussed in terms of Ag NP interaction with the cell membranes of bacteria

Numerical Modelling Study of Behaviour of Consolidated Strata Around Tunnel

Tunnelling in densely populated areas and under existing buildings is common in most of the cities around the world. Upon excavation there are changes that take place in the soil /rock mass and these changes can have an impact on the surface structures. In this paper an attempt is made to assess the behavior of the tunnel in given environment and the associated displacements due to tunneling in a highly consolidated soil/rock mass with two different conditions of earth pressure coefficient. A case study of a tunnel in South India was taken up for studies. 3-dimensional Distinct Element Modelling code was used for the analysis. In the first stage, earth pressure coefficient Ko of 2.2 was taken for the top layers and 1.8 for bottom layers. In the second stage, a value of 2.2 was considered throughout the model. In the third stage displacement generated in the transverse direction, in the presence and absence of the building load was taken into consideration and analysed. Vertical displacements were found to be of considerable magnitude at the crown, showing a decreasing trend towards the surface. Horizontal displacements were of negligible magnitude along the depth. However, maximum displacement was noted at the springing level of the tunnel. Models incorporating weight of buildings showed no noticeable increase in the settlements, as the soil/rock mass is already consolidated.Keywords: Numerical modeling; 3 Dimensional; Distinct Element code; Earth pressure coefficient

Comparative antioxidant and antimicrobial studies of cold and hot bark hydromethanolic extract of Couroupita guianensis Aubl

Couroupita guianensis, known by its common name as cannon ball tree, belongs to Lecythidaceae family, native of south and central America, India and Sri lanka. It’s been in use in traditional medicine and worshipped as sacred tree in india. With the importance of tree in various medicinal aspects as per the reports the present investigation was carried to access the phytochemical components, free radical scavenging and antimicrobial activity of cold and hot hydromethanolic extracts from the barks of medicinally important Couroupita guanensis. Phytochemical screening revealed the presence of total antioxidants, flavonoids, phenols and phytosterols in both cold and hot extracts. Quantitative estimations of the phytochemicals revealed the presence of high contents of total antioxidant activity (598.4 µg/ml), phenol content activity of (417.52 µg/ml) and phytosterols of (133.92 µg/ml) in cold hydromethanolic extracts compared to the hot hydromethanolic extract. The presence of high flavonoid content (417.52 µg/ml) was recorded in hot extract compared to the cold extract. Hot extract gave more scavenging activity with IC50 value (33.5 µg/ml). ABTS radical scavenging activity was found to be more in cold extract with IC50 values (24. µg/ml). Antimicrobial assay showed activity with B. cereus (13.00±0.00mm) and S.aureus (15.00±0.00mm) bacteria showed maximum zone of inhibition compared to the hot extract whereas C. albicans (13.00±O.00mm) showing maximum zone of inhibition compared to the cold extract and was not sensitive to any other fungal forms tested. This investigation pays way to consider Couroupita guianensis, with highly potential antioxidant and antimicrobial components, be used in pharmaceutical companies for the development of phytomedicine for the therapy and treatments

Synthesis and cytotoxic studies of a new series of pyridinoxymethylcoumarins

A series of 3-​(pyridin-​3-​yloxymethyl)​-​chromen-​2-​ones were synthesized by the reaction of substituted 4-​bromomethylcoumarins with 3-​hydroxypyridines. The synthesized compds. were screened for their cytotoxic activities against Dalton's ascitic lymphoma (DAL) and Ehrlich ascites carcinoma (EAC) cell lines. The 2-​(2-​Methyl-​pyridin-​3-​yloxymethyl)​-​benzo[f]​chromen-​3-​one was found to be the most cytotoxic against DAL cell line and 6-​Isopropyl-​3-​(2-​methyl-​pyridin-​3-​yloxymethyl)​-​chromen-​2-​one was found to be the most cytotoxic against EAC cell line