9 research outputs found
Synthesis and Antifungal Activity of Some Organotin(IV) Carboxylates
Six diorganotin(IV) carboxylates prepared by reacting diorganotin(IV) dichlorides with the
respective silver carboxylate have been tested for antifungal activity against Aspergillus. niger, Aspergilluus flavus and Pencillium. citrinum in Sabourand dextrose broth. The compounds
generally exhibit greater fungitoxicity than the diorganotin(IV) dichlorides and the carboxylic acids
from which they were synthesized. In keeping with the generally accepted notion that the
organotin moiety plays an important role in deciding the antifungal activity of an organotin
compound, the diphenyltin(IV) compounds were more active than their di-n-butyltin(IV) analogues.
However, the order of increasing fungitoxicity of the compounds parallels that of the uncomplexed
carboxylic acids. The implications of the results are discussed