Dynamical Origin of Extrasolar Planet Eccentricity Distribution

We explore the possibility that the observed eccentricity distribution of extrasolar planets arose through planet-planet interactions, after the initial stage of planet formation was complete. Our results are based on ~3250 numerical integrations of ensembles of randomly constructed planetary systems, each lasting 100 Myr. We find that for a remarkably wide range of initial conditions the eccentricity distributions of dynamically active planetary systems relax towards a common final equilibrium distribution, well described by the fitting formula dn ~ e exp[-1/2 (e/0.3)^2] de. This distribution agrees well with the observed eccentricity distribution for e > 0.2, but predicts too few planets at lower eccentricities, even when we exclude planets subject to tidal circularization. These findings suggest that a period of large-scale dynamical instability has occurred in a significant fraction of newly formed planetary systems, lasting 1--2 orders of magnitude longer than the ~1 Myr interval in which gas-giant planets are assembled. This mechanism predicts no (or weak) correlations between semimajor axis, eccentricity, inclination, and mass in dynamically relaxed planetary systems. An additional observational consequence of dynamical relaxation is a significant population of planets (>10%) that are highly inclined (>25deg) with respect to the initial symmetry plane of the protoplanetary disk; this population may be detectable in transiting planets through the Rossiter-McLaughlin effect.Comment: Accepted to ApJ, conclusions updated to reflect the current observational constraint

Gravitons and Lightcone Fluctuations II: Correlation Functions

A model of a fluctuating lightcone due to a bath of gravitons is further investigated. The flight times of photons between a source and a detector may be either longer or shorter than the light propagation time in the background classical spacetime, and will form a Gaussian distribution centered around the classical flight time. However, a pair of photons emitted in rapid succession will tend to have correlated flight times. We derive and discuss a correlation function which describes this effect. This enables us to understand more fully the operational significance of a fluctuating lightcone. Our results may be combined with observational data on pulsar timing to place some constraints on the quantum state of cosmological gravitons.Comment: 16 pages and two figures, uses eps

A Search for Hard X-Ray Emission from Globular Clusters - Constraints from BATSE

We have monitored a sample of 27 nearby globular clusters in the hard X-ray band (20-120 keV) for approximately 1400 days using the BATSE instrument on board the Compton Gamma-Ray Observatory. Globular clusters may contain a large number of compact objects (e.g., pulsars or X-ray binaries containing neutron stars) which can produce hard X-ray emission. Our search provides a sensitive (~50 mCrab) monitor for hard X-ray transient events on time scales of >1 day and a means for observing persistent hard X-ray emission. We have discovered no transient events from any of the clusters and no persistent emission. Our observations include a sensitive search of four nearby clusters containing dim X-ray sources: 47 Tucanae, NGC 5139, NGC 6397, and NGC 6752. The non-detection in these clusters implies a lower limit for the recurrence time of transients of 2 to 6 years for events with luminosities >10^36 erg s^-1 (20-120 keV) and ~20 years if the sources in these clusters are taken collectively. This suggests that the dim X-ray sources in these clusters are not transients similar to Aql~X-1. We also place upper limits on the persistent emission in the range 2-10*10^34 erg s^-1 (2 sigma, 20-120 keV) for these four clusters. For 47 Tuc the upper limit is more sensitive than previous measurements by a factor of 3. We find a model dependent upper limit of 19 isolated millisecond pulsars (MSPs) producing gamma-rays in 47 Tuc, compared to the 11 observed radio MSPs in this cluster.Comment: 20 pages; accepted, ApJ; uu encoded tar file; 7 figure

Minimum target prices for production of direct acting antivirals and associated diagnostics to combat Hepatitis C Virus

Combinations of direct-acting antivirals (DAAs) can cure hepatitis C virus (HCV) in the majority of treatment-naïve patients. Mass treatment programs to cure HCV in developing countries are only feasible if the costs of treatment and laboratory diagnostics are very low. This analysis aimed to estimate minimum costs of DAA treatment and associated diagnostic monitoring. Clinical trials of HCV DAAs were reviewed to identify combinations with consistently high rates of sustained virological response across hepatitis C genotypes. For each DAA, molecular structures, doses, treatment duration, and components of retrosynthesis were used to estimate costs of large-scale, generic production. Manufacturing costs per gram of DAA were based upon treating at least 5 million patients per year and a 40% margin for formulation. Costs of diagnostic support were estimated based on published minimum prices of genotyping, HCV antigen tests plus full blood count/clinical chemistry tests. Predicted minimum costs for 12-week courses of combination DAAs with the most consistent efficacy results were: US$122 per person for sofosbuvir+daclatasvir; US$152 for sofosbuvir+ribavirin; US$192 for sofosbuvir+ledipasvir; and US$115 for MK-8742+MK-5172. Diagnostic testing costs were estimated at US$90 for genotyping US$34 for two HCV antigen tests and US$22 for two full blood count/clinical chemistry tests. Conclusions: Minimum costs of treatment and diagnostics to cure hepatitis C virus infection were estimated at US$171-360 per person without genotyping or US$261-450 per person with genotyping. These cost estimates assume that existing large-scale treatment programs can be established. (Hepatology 2015;61:1174–1182

Quantum Inequalities on the Energy Density in Static Robertson-Walker Spacetimes

Quantum inequality restrictions on the stress-energy tensor for negative energy are developed for three and four-dimensional static spacetimes. We derive a general inequality in terms of a sum of mode functions which constrains the magnitude and duration of negative energy seen by an observer at rest in a static spacetime. This inequality is evaluated explicitly for a minimally coupled scalar field in three and four-dimensional static Robertson-Walker universes. In the limit of vanishing curvature, the flat spacetime inequalities are recovered. More generally, these inequalities contain the effects of spacetime curvature. In the limit of short sampling times, they take the flat space form plus subdominant curvature-dependent corrections.Comment: 18 pages, plain LATEX, with 3 figures, uses eps

Nevirapine-Induced Heratotoxicity: Incidence, Risk Factors and Associated Mortality in a Primary Care ART Programme in South Africa

CROI 200

Negative Energy Density States for the Dirac Field in Flat Spacetime

Negative energy densities in the Dirac field produced by state vectors that are the superposition of two single particle electron states are examined. I show that for such states the energy density of the field is not bounded from below and that the quantum inequalities derived for scalar fields are satisfied. I also show that it is not possible to produce negative energy densities in a scalar field using state vectors that are arbitrary superpositions of single particle states.Comment: 11 pages, LaTe

Gravitational vacuum polarization III: Energy conditions in the (1+1) Schwarzschild spacetime

Building on a pair of earlier papers, I investigate the various point-wise and averaged energy conditions for the quantum stress-energy tensor corresponding to a conformally-coupled massless scalar field in the in the (1+1)-dimensional Schwarzschild spacetime. Because the stress-energy tensors are analytically known, I can get exact results for the Hartle--Hawking, Boulware, and Unruh vacua. This exactly solvable model serves as a useful sanity check on my (3+1)-dimensional investigations wherein I had to resort to a mixture of analytic approximations and numerical techniques. Key results in (1+1) dimensions are: (1) NEC is satisfied outside the event horizon for the Hartle--Hawking vacuum, and violated for the Boulware and Unruh vacua. (2) DEC is violated everywhere in the spacetime (for any quantum state, not just the standard vacuum states).Comment: 7 pages, ReV_Te

Focusing Vacuum Fluctuations

The focusing of the vacuum modes of a quantized field by a parabolic mirror is investigated. We use a geometric optics approximation to calculate the energy density and mean squared field averages for scalar and electromagnetic fields near the focus. We find that these quantities grow as an inverse power of the distance to the focus. There is an attractive Casimir-Polder force on an atom which will draw it into the focus. Some estimates of the magnitude of the effects of this focusing indicate that it may be observable.Comment: 20 pages, 4 figures; typos corrected, two refs and some comments adde