Stereoselective routes for the total synthesis of (+)-cryptocarya diacetate

A stereoselective total synthesis of (+)-cryptocarya diacetate (1) was achieved by two different routes (Schemes 2 and 3). The sequences involve LiAlH4/LiI reduction, ring-closing metathesis, Prins cyclization, Wacker oxidation, and Wittig olefination reactions as key steps

Efficient synthesis of bis(indolyl)methanes using nano ceria supported on vinyl pyridine polymer at ambient temperature

Nano ceria supported on vinyl pyridine polymer was found to be an effective and reusable catalyst for the synthesis of bis(indolyl)methanes at room temperature in a protic solvent

Synthesis and Biological Evaluation of 2,4-Diaminopyrimidine-Based Antifolate Drugs against Bacillus anthracis

Due to the innate ability of bacteria to develop resistance to available antibiotics, there is a critical need to develop new agents to treat more resilient strains. As a continuation of our research in this area, we have synthesized a series of racemic 2,4-diaminopyrimidine-based drug candidates, and evaluated them against Bacillus anthracis. The structures are comprised of a 2,4-diaminopyrimidine ring, a 3,4-dimethoxybenzyl ring, and an N-acryloyl-substituted 1,2-dihydrophthalazine ring. Various changes were made at the C1 stereocenter of the dihydrophthalazine moiety in the structure, and the biological activity was assessed by measurement of the MIC and Ki values to identify the most potent drug candidate