Idiopathic central precocious puberty in girls: presentation factors

<p>Abstract</p> <p>Background</p> <p>It is sometimes difficult to distinguish between premature thelarche and precocious puberty in girls who develop breasts before the age of 8 years. We evaluated the frequencies of the signs associated with breast development and the factors influencing the presentation of girls with idiopathic central precocious puberty (CPP).</p> <p>Methods</p> <p>353 girls monitored 0.9 ± 0.7 year after the onset of CPP.</p> <p>Results</p> <p>The age at CPP was < 3 years in 2%, 3–7 years in 38% and 7–8 years in 60% of cases. Pubic hair was present in 67%, growth rate greater than 2 SDS in 46% and bone age advance greater than 2 years in 33% of cases. Breast development was clinically isolated in 70 (20%) cases. However, only 31 of these (8.8% of the population) had a prepubertal length uterus and gonadotropin responses to gonadotropin releasing hormone and plasma estradiol. The clinical picture of CPP became complete during the year following the initial evaluation.</p> <p>25% of cases were obese. The increase in weight during the previous year (3.7 ± 1.4 kg) and body mass index were positively correlated with the statural growth and bone age advance (P < 0.0001).</p> <p>There was no relationship between the clinical-biological presentation and the age at puberty, the interval between the onset of puberty and evaluation, or the presence of familial CPP.</p> <p>Conclusion</p> <p>The variation in presentation of girls with CPP does not depend on their age, interval between the onset and evaluation, or familial factors. This suggests that there are degrees of hypothalamic-pituitary-ovarian activation that are not explained by these factors.</p

How do Illiquid Assets Improce Portfolio Performance? The Case of Bordeaux Wine.

Using a large sample of auctions results of prestigious Bordeaux wines, we provide an analysis of the price formation of wine through auctions sales. Estimating an hedonic price function, we identify the most relevant characteristics influencing the price of Bordeaux wines during auctions sales. The Repeat-Sale Regression (RSR) methodology is used to construct a wine index for the period January 1994-June 1997. We compare the evolution of wine price with several financial indices. We finally study the impact of an investment in wine on the risk-return characteristics of a diversified portfolio of a risk-averse investor.FINANCIAL MARKET ; AUCTIONS

Géodynamique andine : résumé étendus = Andean geodynamics : extended abstracts

L'importante formation miocène Farellones, de l'arc volcanique NS du Chili central, se divise en un membre inférieur, rhyolitique et ignimbritique, et un membre supérieur, andésitique et lavique, associés à un linéament EW de necks basaltiques. Les caractéristiques géochimiques indiquent une identité de source entre l'arc andésitique NS et le linéament basaltique EW et une différence totale de ces volcanismes avec les ignimbrites. (Résumé d'auteur

Use of hyperbranched polymers to form and stabilize metal nanoparticules in water

communication oral