Криомассаж грудной клетки и сильвинитовая спелеотерапия в комплексной медицинской реабилитации больных бронхиальной астмой

Summary. The study was conducted to evaluate therapeutic and preventive effect of chest cryomassage and sylvinite speleotherapy in addition to the standard drug therapy in patients with mild to moderate persistent partially controlled bronchial asthma. Effects of a comprehensive rehabilitation programme were confirmed by a distinct reduction in eosinophilic and neutrophilic inflammation, significant improvements in systemic immunity, lung function, cardiorespitatory hemodynamics, exercise tolerance, and psychological adaptation.Резюме. Изучено лечебно-профилактическое действие криомассажа грудной клетки и сильвинитовой спелеотерапии на фоне стандартного медикаментозного лечения у больных легкой и среднетяжелой персистирующей бронхиальной астмой с частично контролируемым течением. Отчетливый регресс эозинофильного и нейтрофильного воспаления, выраженное улучшение показателей системного иммунитета, внешнего дыхания, легочной кардиогемодинамики, физической толерантности, психологической адаптации позволил констатировать преимущество комплексного применения реабилитационных методов

The use of belatacept in kidney transplantation

Background. Kidney transplantation efficacy is limited by immunosuppression nephrotoxicity, antibody-mediated and chronic rejection. Avoiding immunosuppression nephrotoxicity is a promising strategy to improve long term outcomes. Belatacept, a synthetic immunoglobulin which blocks CD28-B7 pathway of T-lymphocyte costimulation, is considered as an alternative to calcineurin inhibitors in maintenance immunosuppression since it has no nephrotoxicity. Purpose: to evaluate belatacept efficacy and safety for maintenance immunosuppression therapy after kidney transplantatin based on the clinical experience.Material and methods. From March 2017 to May 2018, we used belatacept in five kidney transplant recipients (one female and four males aged from 4 to 21 years) in the Kidney Transplantation Department of Petrovsky National Research Centre of Surgery Three kidneys were taken from related living donors, two kidney grafts were from deceased donors. Conversion from CNI to belatacept was performed between 6 and 112 month after transplantation. Patients were followed-up for average 12 months after conversion. We have described here these five cases, providing individual indications and the outcome of conversion.Results. The conversion failed in two children switched to belatacept with the purpose to improve compliance. Three patients switched to belatacept because of tacrolimus toxicity demonstrated good results in one year follow up.Conclusion. Belatacept demonstrated good results if was used instead of calcineurin inhibitors when the latter were poorly tolerated. The use of belatacept in multidrug immunosuppression in noncompliant patients was ineffective

Обоснование включения общих ванн с биолонгом в лечебно-реабилитационный комплекс больных хронической обструктивной болезнью легких и бронхиальной астмой

Summary. Clinical and functional investigations demonstrated a benefit from inclusion of total bath with Biolong in a therapeutic and rehabilitation programme for patients with COPD and asthma. The advantages of administering the hydropathical factor with anti-hypoxic and anti-oxidant effects to patients with bronchial asthma were demonstrated.Резюме. В работе представлены результаты клинико-функциональных исследований, обосновывающих целесообразность включения в лечебно-реабилитационный комплекс больных хронической обструктивной патологией органов дыхания общих ванн с биолонгом. Установлено преимущество применения бальнеофактора, обладающего свойствами антигипоксанта-антиоксиданта, у больных бронхиальной астмой