MSSM-inspired multifield inflation

Despite the fact that experimentally with a high degree of statistical significance only a single Standard Model--like Higgs boson is discovered at the LHC, extended Higgs sectors with multiple scalar fields not excluded by combined fits of the data are more preferable theoretically for internally consistent realistic models of particle physics. We analyze the inflationary scenarios which could be induced by the two-Higgs doublet potential of the Minimal Supersymmetric Standard Model (MSSM) where five scalar fields have nonminimal couplings to gravity. Observables following from such MSSM-inspired multifield inflation are calculated and a number of consistent inflationary scenarios are constructed. Cosmological evolution with different initial conditions for the multifield system leads to consequences fully compatible with observational data on the spectral index and the tensor-to-scalar ratio. It is demonstrated that the strong coupling approximation is precise enough to describe such inflationary scenarios.Comment: 27 pages, 4 figures, 5 tables. Version to appear in JHEP. Additions made to the text of the Introduction dealing with the issues of conformity of this multifield model and models of N=1 supergravity (pages 2-3). Added new inflationary scenarios, which are an artifact of such analysis (pages 11-12, Tables 1-4). Additional comments on page 9 and page 13. New references adde

Connection between the Green functions of the supersymmetric pair of Dirac Hamiltonians

The Sukumar theorem about the connection between the Green functions of the supersymmetric pair of the Schr\"odinger Hamiltonians is generalized to the case of the supersymmetric pair of the Dirac Hamiltonians.Comment: 12 pages,Latex, no figure

X-RAY DIAGNOSTICS OF PATHOLOGY OF MUSCULOSKELETAL SYSTEM USING DX-D FULL LEG FULL SPINE SYSTEM

Применение системы DX-D Full Leg Full Spine относится к современным технологиям рентгенологического исследования, позволяющего получить высокое качество рентгенограммы при минимальной лучевой нагрузке. Система DX-D Full Leg Full Spine обеспечивает технологический процесс получения изображений для диагностики ортопедической патологии в положении стоя. Основная функция данной системы - автоматический технологический процесс, позволяющий на основе индивидуальных анатомических особенностей пациента за короткий промежуток времени и с высокой степенью точности подобрать необходимую металлоконструкцию, соответствующую объему оперативного вмешательства. В описанном клиническом наблюдении показано выполнение исследования нижних конечностей на рентгенологическом аппарате DX-D 300 с использованием системы DX-D Full Leg Full Spine с определением укорочения ротационной деформации правой нижней конечности, оценки структуры костей, соотношения суставных поверхностей в тазобедренных и коленных суставах

BONE MINERAL DENSITY INDICES IN PATIENTS WITH CERVICAL OSTEOCHONDROSIS

According to the data of the World Health Organization, osteoporosis takes the fourth place among non-infectious diseases after cardiovascular, oncologic disorders and diabetes mellitus. Clinical manifestations of osteoporosis with the root syndrome are not that different from those of radicular symptoms at degenerative-dystrophic processes in the spine. Our purpose was to study the state of upper extremities bone tissue in patients with clinical manifestations of cervical osteochondrosis. There were 40 patients under our observation diagnosed with cervical osteochondrosis, 26 of them - with stages 1 and 2 of osteochondrosis development, and 14 patients - with stage 3. Conducted densitometry examinations of upper extremities bone tissue revealed correlation between bone tissue state and both the time of the onset of the pathological process and its severity. In patients with stage 3 osteochondrosis, bone tissue mineral density on the affected extremity was lowered down to osteoporosis, and naturally, such cases require further treatment

Assessment of the effectiveness of surgical treatment of patients with massive ruptures of rotator cuff tendons using latissimus dorsi tendon transposition

Rotator cuff ruptures are the most common injuries of shoulder joint with an incidence of about 20 %. This pathology is more common in adults over 60 years of age because it is caused by degenerative changes in the tendon. Massive injuries account for 10–40 % of all rotator cuff injuries. Currently, there is no unified surgical tactics for the treatment of patients with massive ruptures of rotator cuff tendons.The aim. To assess the efficiency of transposition of the latissimus dorsi tendon in patients with massive ruptures of the rotator cuff tendon.Materials and methods. The study included 15 patients with Patte stage III massive ruptures of the rotator cuff who had transposition of the latissimus dorsi tendon.Results. The article presents clinical cases of surgical treatment of patients. The following criteria were assessed: mean age; time since injury; duration of the surgery; blood loss volume; functional results by the ASES (American Shoulder and Elbow Surgeons) Shoulder Score. Taking into account the ASES Shoulder Score indicators 1 year after the surgical treatment, the following results were obtained: excellent results – in 9 (53.3 %) cases; good results – in 1 (13.4 %) case; satisfactory results – in 5 (33.3 %) cases.Conclusion. When preserving the articular cartilage, the method of choice in the treatment of patients with massive ruptures of rotator cuff tendons is transposition of the latissimus dorsi tendon. At the same time, an incomplete restoration of the function of the injured limb was registered in 33.3 % of patients, which requires further study and modification of the known method of transposition of the latissimus dorsi tendon

Induced astigmatism and concomitant high myopia correction with femtosecond laser-assisted intrastromal MyoRing implantation

Purpose. Analysis of the results of astigmatism correction after penetrating keratoplasty and concomitant high myopia using the MyoRing ring implantation, clinical case as an example.Material and methods. Patient G., 51 years old, underwent surgery to correct astigmatism and concomitant high myopia. MyoRing was implanted in the right eye within corneal transplant limits using femtosecond laser-assisted intrastromal MyoRing implantation. Before the surgery uncorrected visual acuity at the operated eye was 0.01; corrected visual acuity 0.06; spherical component of refraction was (-)6.0 D, cylindrical component was (-)8.0 D. Mean keratometry in the right eye was 43.96 D. Corneal hysteresis was 6.5 mm Hg, corneal resistance factor was 5.5 mm Hg, cornea thickness in center was 529 mkm. The patient was followed up for one year.Results. In 12 months after the surgery visual acuity of the right eye without correction was 0.7 and 0.8 with correction. Spherical component was (-)1.0 D, cylindrical component was (-)2.0 D. Mean keratometry in the right eye was 35.10 D. Corneal hysteresis was 7.2 mm Hg, corneal resistance factor was 6.3 mm Hg, cornea thickness in center was 533 mkm. The patient was satisfied with the result of operation.Conclusion. Femtosecond laser-assisted intrastromal MyoRing implantation for correction induced astigmatism after penetrating keratoplasty and concomitant high myopia is efficient, safe and provides strengthening of biomechanical properties of the cornea besides refractive and visual effect

Mechanisms of interacting <i>Helicobacter pylori</i> with gastric mucosal epithelium. II. A reaction of gastric epithelium on <i>Helicobacter pylori</i> colonization and persistence

Gastric and duodenal recurrent inflammatory diseases have a high prevalence, but the role played by microbes in its development remained unclear. However, the data published in 1983 by Marshall and Warren about isolating Helicobacter pylori from the stomach mucosa of the patient with gastritis and proposing relevant cultivation methods was the turning point in investigating etiology of the upper digestive tract inflammatory disorders. Moreover, it was shown that the majority of H. pylori spp. are found within the gastric lumen upon colonization, whereas around 20% of them are attached to the epithelial cells in the stomach. In addition, effects of interacting H. pylori with gastric epithelium and activation of some defense mechanisms due to bacterial colonization and spreading were analyzed. It was found that along with triggering pro-inflammatory response induced by proteins VacA as well as phosphorylated/unphosphorylated CagA, wherein the latter is able to induce a set of protective reactions H. pylori disrupts intercellular contacts, affects epithelial cell polarity and proliferation, and activates SHP-2 phosphatase resulting in emerging diverse types of cellular responses. The activation mechanisms for the mitogen-activated protein kinase (MAPK) pathway were discussed. The ability of H. pylori to regulate apoptosis, particularly via its suppression, by expressing ERK kinase and protein MCL1 facilitating bacterial survival in the gastric mucosa as well as beneficial effects related to bacterial circulation on gastric epithelial cell survival elicited by anti-apoptotic factors were also examined. Of note, persistence of H. pylori are mainly determined by activating transcriptional factors including NF-κB, NFAT, SRF, T-cell lymphoid enhancing factor (TCF/LEF), regulating activity of MCL1 protein, in turn, being one of the main anti-apoptotic factors, as well as induced production of the migration inhibitory factor (MIF). The role of VacA cytotoxin in triggering epithelial cell apoptosis via caspase-mediated pathways was also considered. Infection with H. pylori is accompanied by release of proinflammatory cytokine cocktail detected both in vitro and in vivo. In particular, bacterial urease activating transcriptional factor NF-κB was shown to play a crucial role in inducing cytokine production. Moreover, such signaling pathways may be activated after H. pylori is attached to the cognate receptor in the gastric epithelial surface by interacting with CD74 and MHC class II molecules. Finally, a role for various CD4+ T cell subsets, particularly type 17 T helper cells (Th17) in inducing immune response against H. pylori antigens in gastric mucosa was revealed were also discussed

Organization of Educational Environment at Pedagogical University: Concepts and Scenario of Changes

The subjects of education satisfaction analysis with the teacher training results at the University was carried out. The training deficiencies and new challenges were identified, which made it possible to determine the guidelines for the development of pedagogical university. A variant to transform the organizational scheme of communications between university departments was presented to increase the efficiency of educational environment organization for professional training of future teachers