The role of B-1 cells in inflammation

B-1 lymphocytes exhibit unique phenotypic, ontogenic, and functional characteristics that differ from the conventional B-2 cells. B-1 cells spontaneously secrete germline-like, repertoire-skewed polyreactive natural antibody, which acts as a first line of defense by neutralizing a wide range of pathogens before launching of the adaptive immune response. Immunomodulatory molecules such as interleukin-10, adenosine, granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-35 are also produced by B-1 cells in the presence or absence of stimulation, which regulate acute and chronic inflammatory diseases. Considerable progress has been made during the past three decades since the discovery of B-1 cells, which has improved not only our understanding of their phenotypic and ontogenic uniqueness but also their role in various inflammatory diseases including influenza, pneumonia, sepsis, atherosclerosis, inflammatory bowel disease, autoimmunity, obesity and diabetes mellitus. Recent identification of human B-1 cells widens the scope of this field, leading to novel innovations that can be implemented from bench to bedside. Among the vast number of studies on B-1 cells, we have carried out a literature review highlighting current trends in the study of B-1 cell involvement during inflammation, which may result in a paradigm shift toward sustainable therapeutics in various inflammatory diseases

High Energy Field Theory in Truncated AdS Backgrounds

In this letter we show that, in five-dimensional anti-deSitter space (AdS) truncated by boundary branes, effective field theory techniques are reliable at high energy (much higher than the scale suggested by the Kaluza-Klein mass gap), provided one computes suitable observables. We argue that in the model of Randall and Sundrum for generating the weak scale from the AdS warp factor, the high energy behavior of gauge fields can be calculated in a {\em cutoff independent manner}, provided one restricts Green's functions to external points on the Planck brane. Using the AdS/CFT correspondence, we calculate the one-loop correction to the Planck brane gauge propagator due to charged bulk fields. These effects give rise to non-universal logarithmic energy dependence for a range of scales above the Kaluza-Klein gap.Comment: LaTeX, 7 pages; minor typos fixe

Lepton Flavor Violation and the Tau Neutrino Mass

We point out that, in the left-right symmetric model of weak interaction, if $\nu_\tau$ mass is in the keV to MeV range, there is a strong correlation between rare decays such as $\tau \rightarrow 3 \mu, \tau \rightarrow 3 e$ and the $\nu_\tau$ mass. In particular, we point out that a large range of $\nu_\tau$ masses are forbidden by the cosmological constraints on $m_{\nu_\tau}$ in combination with the present upper limits on these processes.Comment: UMDHEP 94-30, 14 pages, TeX file, (some new references added

Multiple start codons and phosphorylation result in discrete Rad52 protein species

The sequence of the Saccharomyces cerevisiae RAD52 gene contains five potential translation start sites and protein-blot analysis typically detects multiple Rad52 species with different electrophoretic mobilities. Here we define the gene products encoded by RAD52. We show that the multiple Rad52 protein species are due to promiscuous choice of start codons as well as post-translational modification. Specifically, Rad52 is phosphorylated both in a cell cycle-independent and in a cell cycle-dependent manner. Furthermore, phosphorylation is dependent on the presence of the Rad52 C terminus, but not dependent on its interaction with Rad51. We also show that the Rad52 protein can be translated from the last three start sites and expression from any one of them is sufficient for spontaneous recombination and the repair of gamma-ray-induced doublestrand breaks

Mother Moose: Generating Extra Dimensions from Simple Groups at Large N

We show that there exists a correspondence between four dimensional gauge theories with simple groups and higher dimensional gauge theories at large N. As an example, we show that a four dimensional {N}=2 supersymmetric SU(N) gauge theory, on the Higgs branch, has the same correlators as a five dimensional SU(N) gauge theory in the limit of large N provided the couplings are appropriately rescaled. We show that our results can be applied to the AdS/CFT correspondence to derive correlators of five or more dimensional gauge theories from solutions of five dimensional supergravity in the large t'Hooft coupling limit.Comment: 12 pages, references adde

Spectral Difference Equations Satisfied by KP Soliton Wavefunctions

The Baker-Akhiezer (wave) functions corresponding to soliton solutions of the KP hierarchy are shown to satisfy eigenvalue equations for a commutative ring of translational operators in the spectral parameter. In the rational limit, these translational operators converge to the differential operators in the spectral parameter previously discussed as part of the theory of "bispectrality". Consequently, these translational operators can be seen as demonstrating a form of bispectrality for the non-rational solitons as well.Comment: to appear in "Inverse Problems

Power counting and effective field theory for charmonium

We hypothesize that the correct power counting for charmonia is in the parameter Lambda_QCD/m_c, but is not based purely on dimensional analysis (as is HQET). This power counting leads to predictions which differ from those resulting from the usual velocity power counting rules of NRQCD. In particular, we show that while Lambda_QCD/m_c power counting preserves the empirically verified predictions of spin symmetry in decays, it also leads to new predictions which include: A hierarchy between spin singlet and triplet octet matrix elements in the J/psi system. A quenching of the net polarization in production at large transverse momentum. No end point enhancement in radiative decays. We discuss explicit tests which can differentiate between the traditional and new theories of NRQCD.Comment: 18 pages, 1 figure Replaced plot of the psi polarization parameter alpha as a function of transverse momentum. Alpha is now closer to zero for large transverse moment

Effects of e−e+νee^- e^+ \nu_e Decays of Tau Neutrinos Near A Supernova

We revisit the constraints implied by SN 1987 A observations on the decay rate of a multi-MeV $\nu_\tau$ decaying into the visible channel $\nu_\tau \rightarrow e^+ e^- \nu_e$, if its lifetime is more than 10 {\it sec.}. We discuss its implication for the minimal left-right symmetric model with see-saw mechanism for neutrino masses. We also speculate on the possible formation of a ``giant Capacitor" in intergalactic space due to the decay of "neutronization" $\nu_\tau$'s and spin allignment possibility in the supernova.Comment: 29 Pages, Tex file, UMDHEP 94-4

A crossover intervention trial evaluating the efficacy of a chlorhexidine-impregnated sponge in reducing catheter-related bloodstream infections among patients undergoing hemodialysis

BACKGROUND: Catheter-related bloodstream infections (BSI) account for the majority of hemodialysis-related infections. There are no published data on the efficacy of the chlorhexidine-impregnated foam dressing at reducing catheter-related BSI in hemodialysis patients. DESIGN: Prospective non-blinded cross-over intervention trial to determine the efficacy of a chlorhexidine-impregnated foam dressing (Biopatch®) to reduce catheter-related BSI in hemodialysis patients. SETTING: Two outpatient dialysis centers PATIENTS: A total of 121 patients who were dialyzed through tunneled central venous catheters received the intervention during the trial. METHODS: The primary outcome of interest was the incidence of catheter-related bloodstream infections. A nested cohort study of all patients who received the Biopatch® Antimicrobial Dressing was also conducted. Backward stepwise logistic regression analysis was used to determine independent risk factors for development of BSI. RESULTS: 37 bloodstream infections occurred in the intervention group for a rate of 6.3 BSIs/1000 dialysis sessions and 30 bloodstream infections in the control group for a rate of 5.2 BSIs/1000 dialysis sessions and [RR 1.22, CI (0.76, 1.97); P=0.46]. The Biopatch® Antimicrobial Dressing was well-tolerated with only two patients (<2%) experiencing dermatitis that led to its discontinuation. The only independent risk factor for development of BSI was dialysis treatment at one dialysis center [aOR 4.4 (1.77, 13.65); P=0.002]. Age ≥ 60 years [aOR 0.28 (0.09, 0.82); P=0.02] was associated with lower risk for BSI. CONCLUSION: The use of a chlorhexidine-impregnated foam dressing (Biopatch®) did not decrease catheter-related BSIs among hemodialysis patients with tunneled central venous catheters

Yukawa Deflected Gauge Mediation in Four Dimensions

We construct a four dimensional realization of a higher dimensional model, Yukawa deflected gauge mediation, in which supersymmetry breaking is communicated to the visible sector through both gauge and Yukawa interactions. The reduction to four dimensions is achieved by `deconstructing' or `latticizing' the extra dimension. Three sites (gauge groups) are sufficient to reproduce the spectrum of the higher dimensional model. The characteristic features of Yukawa deflected gauge mediation, in particular, alignment of squarks and quarks, and a natural solution to the mu problem, carry over to the deconstructed version of the model. We comment on the implications of our results for a solution of the mu problem in the context of deconstructed gaugino mediation.Comment: 11 pages, 1figur