609 research outputs found
A New Symmetry for QED
We demonstrate that QED exhibits a previously unobserved symmetry. Some
consequences are discussed.Comment: 9 pages, MZ-TH/93-02, DIAS-STP-93-0
Construction and Consequences of Coloured Charges in QCD
This talk reports on work aimed at improving our understanding of charged
states in gauge theories.Emphasis is placed on different ways of
implementingthe gauge invariance of physical states. QED perturbative
calculations are used to stress that gauge invariance is not enough: only a
subset of such states have a direct physical significance. In QCD a
non-perturbative obstruction means that quarks and gluons cannot form physical
states and as such these particles are not truely observables. This sets a
fundamental limit on the constituent quark model.Comment: 4 pages, latex, needs sprocl.st
The Fermi surface and f-valence electron count of UPt3
Combining old and new de Haas-van Alphen (dHvA) and magnetoresistance data,
we arrive at a detailed picture of the Fermi surface of the heavy fermion
superconductor UPt3. Our work was partially motivated by a new proposal that
two 5f valence electrons per formula unit in UPt3 are localized by correlation
effects -- agreement with previous dHvA measurements of the Fermi surface was
invoked in its support. Comprehensive comparison with our new observations
shows that this 'partially localized' model fails to predict the existence of a
major sheet of the Fermi surface, and is therefore less compatible with
experiment than the originally proposed 'fully itinerant' model of the
electronic structure of UPt3. In support of this conclusion, we offer a more
complete analysis of the fully itinerant band structure calculation, where we
find a number of previously unrecognized extremal orbits on the Fermi surface.Comment: 23 pages, 12 figures, latex, iopart clas
Symmetry breaking, conformal geometry and gauge invariance
When the electroweak action is rewritten in terms of SU(2) gauge invariant
variables, the Higgs can be interpreted as a conformal metric factor. We show
that asymptotic flatness of the metric is required to avoid a Gribov problem:
without it, the new variables fail to be nonperturbatively gauge invariant. We
also clarify the relations between this approach and unitary gauge fixing, and
the existence of similar transformations in other gauge theories.Comment: 11 pages. Version 2: typos corrected, discussion of Elitzur's theorem
added. Version to appear in J.Phys.
A Technical Introduction to Transmission Electron Microscopy for Soft-Matter:Imaging, Possibilities, Choices, and Technical Developments
With a significant role in material sciences, physics, (soft matter) chemistry, and biology, the transmission electron microscope is one of the most widely applied structural analysis tool to date. It has the power to visualize almost everything from the micrometer to the angstrom scale. Technical developments keep opening doors to new fields of research by improving aspects such as sample preservation, detector performance, computational power, and workflow automation. For more than half a century, and continuing into the future, electron microscopy has been, and is, a cornerstone methodology in science. Herein, the technical considerations of imaging with electrons in terms of optics, technology, samples and processing, and targeted soft materials are summarized. Furthermore, recent advances and their potential for application to soft matter chemistry are highlighted
Spin Polarization and Magneto-Coulomb Oscillations in Ferromagnetic Single Electron Devices
The magneto-Coulomb oscillation, the single electron repopulation induced by
external magnetic field, observed in a ferromagnetic single electron transistor
is further examined in various ferromagnetic single electron devices. In case
of double- and triple-junction devices made of Ni and Co electrodes, the single
electron repopulation always occurs from Ni to Co electrodes with increasing a
magnetic field, irrespective of the configurations of the electrodes. The
period of the magneto-Coulomb oscillation is proportional to the single
electron charging energy. All these features are consistently explained by the
mechanism that the Zeeman effect induces changes of the Fermi energy of the
ferromagnetic metal having a non-zero spin polarizations. Experimentally
determined spin polarizations are negative for both Ni and Co and the magnitude
is larger for Ni than Co as expected from band calculations.Comment: 4 pages, 3 figures, uses jpsj.sty, submitted to J. Phys. Soc. Jp
Synthetic DNA immunotherapy in biochemically relapsed prostate cancer
Background: INO-5150 (PSA and PSMA) +/- INO-9012 (IL-12), a synthetic DNA immunotherapy, was assessed for safety, immunogenicity and efficacy in biochemically recurrent prostate cancer patients (pts).
Methods: Phase I, open-label, multi-center study in the US included pts with rising PSA after surgery and/or RT, PSA doubling time (PSADT) \u3e3 months (mos), testosterone \u3e150 ng/dL and no concurrent ADT. Safety, immunogenicity and efficacy (PSA kinetics, PFS) were evaluated in 4 treatment arms of 15 pts each. Arms A: 2mg INO-5150, B: 8.5 mg INO-5150, C: 2mg INO-5150 + 1mg INO-9012 and D: 8.5mg INO-5150 + 1mg INO-9012. Pts received 4 IM doses of vaccine followed by electroporation on day 0, wks 3, 12 and 24 and were followed for 72 wks.
Results: 50/61 (82%) pts completed all visits and treatments were well tolerated with no safety concerns. Median PFS for overall population [N = 61, baseline (D0) PSADT range (mos) 1.5-217.1, median 9.8] and for a subset of pts with D0 PSADT ≤12mos (N = 36) has not yet been reached (FU 3-19 mos). 86% of pts with D0 PSADT ≤12 mos were progression free through 19mos FU. 27 out of 36 (75%) pts with D0 PSADT≤ 12 mos had disease stabilization at wks 27 evidenced by significant improvement in log2PSA change over time (slope) and PSADT from D0 (Slope=0.19 declined to 0.1, PSADT=5.3 improved to 10.1 mos, p = \u3c0.0001). This effect was maintained at wk 72 (Slope=0.09, PSADT=10.6, p = \u3c0.0001). Immunogenicity was observed in 77% (47/61) of pts by multiple immunologic assessments. Patient immunogenicity to INO-5150 as determined by CD38 and Perforin + CD8 T cell immune reactivity correlated with attenuated % PSA rise compared to pts without reactivity (p = 0.05, n = 50).
Conclusions: INO-5150 +/- INO-9012 was safe, well tolerated and immunogenic. Clinical efficacy was observed in the patients with D0 PSADT≤ 12 mos as evidenced by a significant dampening of log2PSA change over time and increased PSADT up to 72 weeks FU. Additional genomic analyses are ongoing to further elucidate the correlation of immunologic efficacy and clinical benefit. (NCT02514213)
Geometrical Aspects Of BRST Cohomology In Augmented Superfield Formalism
In the framework of augmented superfield approach, we provide the geometrical
origin and interpretation for the nilpotent (anti-)BRST charges, (anti-)co-BRST
charges and a non-nilpotent bosonic charge. Together, these local and conserved
charges turn out to be responsible for a clear and cogent definition of the
Hodge decomposition theorem in the quantum Hilbert space of states. The above
charges owe their origin to the de Rham cohomological operators of differential
geometry which are found to be at the heart of some of the key concepts
associated with the interacting gauge theories. For our present review, we
choose the two -dimensional (2D) quantum electrodynamics (QED) as a
prototype field theoretical model to derive all the nilpotent symmetries for
all the fields present in this interacting gauge theory in the framework of
augmented superfield formulation and show that this theory is a {\it unique}
example of an interacting gauge theory which provides a tractable field
theoretical model for the Hodge theory.Comment: LaTeX file, 25 pages, Ref. [49] updated, correct page numbers of the
Journal are give
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