PLACE OF LOW-MOLECULAR-WEIGHT HEPARINS IN INTENSIVE THERAPY OF HEPATIC INSUFFICIENCY

The practical significance of heparin low-molecular fractions as inhibitors of inflammation and antithrombin III consumption reduction were studied. That is most critical in acute hepatic failure. The study was performed using the low-molecular-weight heparin (Nadroparin calcium) in low (prophylactic) doses of 2000 anti-factor Xa units daily per 1 meter squared in the form of continuous intravenous infusion. The cohort study proved the nadroparin positive effect on carbohydrate and protein metabolism in children with acute poisoning by hepatotoxic poisons, The significant decrease in the quantitative assessment of disseminated intravascular coagulation relative to the comparison group has been revealed, and the decrease in 28-day mortality from 42 to 13 % has been found in children receiving nadroparin. Conclusions are drawn on the feasibility of introducing low molecular weight heparins into the intensive care regimen of liver failure

EXPERIENCE OF SURGICAL TREATMENT OF BENIGN TUMORS AND DYSPLATIC PROCESSES OF THE MANDIBLE BY THE METHOD OF REPLANTATION OF THE RECTURAL BONE, SUBJECTED TO FREEZING

The purpose of the study is the development of indications and evaluation of the long-term results of surgical treatment of benign tumors and dysplastic processes of the mandible by the method of replantation of resected bone exposed to extraorganic freezing. Material and methods. A method for the surgical treatment of benign tumors and dysplastic processes of the mandible has been developed. It involves resection of an afflicted by pathological process segment of bone within healthy tissues, its mechanical processing, freezing in liquid nitrogen followed by slow thawing, and replantation. The evaluation of the treatment results has been carried out on the base of clinical, radiation and functional research methods. Long-term follow-up after surgery has been ranged from one to 25 years. Results and discussion. Positive results of surgical treatment were recorded in 72 patients (88,9 %). The indications for the developed method use have been established. It was found that the reconstruction of the mandible with a resected bone segment exposed to extraorganic cryosurgery, eliminates the recurrence of a benign tumor, provides for the restoration of the anatomical integrity of the jaw, and reduces the invasiveness of the operation. Conclusion. Long-term clinical experience has shown that mandible direct reconstruction in the surgical treatment of benign tumors and dysplastic processes with the method of resection, external freezing of the afflicted jaw area and its replantation is available, simple, and highly effective and can be recommended in the practice of medical institutions