Ixodes scapularis density and Borrelia burgdorferi prevalence along a residential-woodland gradient in a region of emerging Lyme disease risk.

The environmental risk of Lyme disease, defined by the density of Ixodes scapularis ticks and their prevalence of Borrelia burgdorferi infection, is increasing across the Ottawa, Ontario region, making this a unique location to explore the factors associated with environmental risk along a residential-woodland gradient. In this study, we collected I. scapularis ticks and trapped Peromyscus spp. mice, tested both for tick-borne pathogens, and monitored the intensity of foraging activity by deer in residential, woodland, and residential-woodland interface zones of four neighbourhoods. We constructed mixed-effect models to test for site-specific characteristics associated with densities of questing nymphal and adult ticks and the infection prevalence of nymphal and adult ticks. Compared to residential zones, we found a strong increasing gradient in tick density from interface to woodland zones, with 4 and 15 times as many nymphal ticks, respectively. Infection prevalence of nymphs and adults together was 15 to 24 times greater in non-residential zone habitats. Ecological site characteristics, including soil moisture, leaf litter depth, and understory density, were associated with variations in nymphal density and their infection prevalence. Our results suggest that high environmental risk bordering residential areas poses a concern for human-tick encounters, highlighting the need for targeted disease prevention

PAC LEARNING WITH GENERALIZED SAMPLES AND AN APPLICATION TO STOCHASTIC GEOMETRY 1

In this paper, we introduce an extension of the standard PAC model which allows the use of generalized samples. We view a generalized sample as a pair consisting of a functional on the concept class together with the value obtained by the functional operating on the unknown concept. It appears that this model can be applied to a number of problems in signal processing and geometric reconstruction to provide sample size bounds under a PAC criterion. We consider a specific application of the generalized model to a problem of curve reconstruction, and discuss some connections with a result from stochastic geometry. l'l'lis work was supported by the U.S. Army Researclh Office ut(ler Contract. 1)AAL03-86-K-0171, by the Depatrtnuen