Efficacy and tolerance of Arifam in patients with arterial hypertension over 55 years old: main results of the observational program ARBALET

Aim. To assess the effectiveness and safety of therapy with fixed combination of amlodipine/indapamide (Arifam) in outpatients with arterial hypertension (AH) over 55 years old.Material and methods. We included 2217 patients in the observation — 692 (31%) men and 1521 (69%) women. Changes in the course of 3-month therapy of systolic and diastolic blood pressure (BP), the frequency of achievement of target BP levels (<140/90 mm Hg), responder rate during the clinical and ambulatory blood pressure measurement were evaluated and.Results. With the use of Arifam fixed combination 89,81% of patients achieved target BP level by the 3rd month of treatment, 73,77% of patients achieved positive response in 2 weeks, 94,88% of patients — after 1 month. According to the selfcontrol data, the target BP level (<135/85 mm Hg) was achieved in 79,47% of patients. The number of patients with pulse BP <60 mm Hg increased after 3 months of treatment to 81,97%. Also 48 (2,17%) patients discontinued participation; 6 (0,28%) patients — due to the development of adverse events.Conclusion. The ARBALET program has demonstrated high efficacy and tolerance of using Arifam fixed combination in outpatients over 55 years old with hypertension

Clinical effectiveness of dynamical electroneurostimulation in combined therapy for hypertension

To study possibilities of improving of blood pressure (BP) control using the DENS device in patients with arterial hypertension stages I-II. Placebo-controlled study of antihypertensive effect of diaDENS-cardio in 60 patients with arterial hypertension taking regular antihypertensive therapy. Measurements of BP were performed by self BP control and 24 hours monitoring of BP. According to results of both self BP control (123,4 ± 5,4 vs 144,9 ± 7,4 мм рт.ст., p < 0,05) and 24 hours monitoring of BP (125,8 ± 4,9 vs 147,1 ± 11,7 mm Hg, p < 0,05) decrease in systolic BP in groups using device diaDENS-cardio was observed. Decrease in BP in patients using device diaDENS-cardio resulted in reduced doses of ACE (enalapril 7,8 ± 5,7 vs 19,7 ± 10,2 mg/days, p < 0,01) and beta-blockers doses (metoprolol 40,8 ± 19,1 vs 75,8 ± 35,6 mg/days, p < 0,05) for optimum BP control. Using of active device diaDENS-cardio in patients with arterial hypertension helps to attain targeted BP values with lower drug doses

DiaDENS-Cardio potential in resistant arterial hypertension treatment

Aim. To investigate a new technique of transcutaneous electroneurostimulation of reflexogenic zones by shortimpulse current (DiaDENS-Cardio) as a potential method to improve blood pressure (BP) control in patients with arterial hypertension (AH) uncontrolled by three-component therapy.Material and methods. A placebo-controlled study of DiaDENS-Cardio device included 60 AH patients, receiving regular three-component antihypertensive therapy but failing to achieve the target BP level &lt;140/90 mm Hg. BP was self-measured (SMBP) and monitored for 24 hours (24-hour BPM).Results. Systolic BP decreased after two days of DiaDENS-Cardio therapy, as demonstrated by SMBP (123,4+5,4 vs. 144,9+7,4 mm Hg; p&lt;0,05) and 24-hour BPM (125,8+4,9 vs. 147,1+11,7 mm Hg; p&lt;0,05).Conclusion. DiaDENS-Cardio therapy significantly improved BP control in patients with resistant AH

Osborn wave in a patient with COVID-19: a case report

The classic Osborn wave in the form of characteristic changes at the depolarization end or ventricular repolarization beginning is more often associated with hypothermia (body temperature below 35,6° C). Some researchers have noticed Osborn wave at normal body temperature, various pathological conditions and diseases: hypercalcemia, myocardial ischemia, postoperative pericarditis, with central nervous system, etc. We presented a case report of a 72-year-old female inpatient with moderate COVID-19, confirmed by polymerase chain reaction, and 48% lung damage. Before admission to the hospital, electrocardiogram had no Osborn wave, which first appeared at admission. There was a significant increase in serum C-reactive protein and a moderate increase in serum biomarkers and no changes in intervals and segments on the electrocardiogram. The appearance of Osborn wave may be associated with intramyocardial electrolyte imbalance, a consequence of antiviral and antibacterial therapy that violate intraventricular conduction