Clinical and pathogenic aspects of vibrational disease and comorbid pathologies.

Despite the tendency to decrease in the level of vibrational disease morbidity, this pathology is third in the structure of occupational diseases in Ukraine. According to research design, we have examined 178 vibrational disease patients of I and II degree due to local vibration. They have been divided into 3 groups: first — 66 patients with vibrational disease and chronic obstructive pulmonary disease; second — 60 patients with vibrational disease and arterial hypertension of II degree, and group of comparison – 52 patients with isolated course of vibrational disease. We have used clinical and physiological, ELISA methods to estimate cytokines levels in these patients. We have found that clinical signs of vibrational disease depend on vibrational disease progressing and comorbid pathologies. Overlay of chronic obstructive pulmonary disease to vibra­tional disease significantly worsens disease course, manifested by augmenting of clinical symptoms, neurovascular and trophic violations. Comorbid course of vibrational disease and arterial hypertension leads to respective worsening of cardio-vascular pathology. One of the mechanisms of development and progressing of vibrational disease is imbalance of cytokine chain of immunity — increase of the amount of inflammatory cytokine TNF-α and decrease of anti-inflammatory — IL-10. Overlay of chronic obstructive pulmonary disease enhances this trend. In patients with comorbid course of vibrational disease and arterial hypertension we have observed development of secondary dysregulatory state of immunocompetent system. This is proved by increased levels of inflammatory cytokines (TNF-α by 62.5 % and IL-8 by 46.5 %), and decreased activity of melatonin by 35.0 % in comparison with group of patients with isolated vibrational disease

Clinical and pathogenic aspects of vibrational disease and comorbid pathologies.

Despite the tendency to decrease in the level of vibrational disease morbidity, this pathology is third in the structure of occupational diseases in Ukraine. According to research design, we have examined 178 vibrational disease patients of I and II degree due to local vibration. They have been divided into 3 groups: first — 66 patients with vibrational disease and chronic obstructive pulmonary disease; second — 60 patients with vibrational disease and arterial hypertension of II degree, and group of comparison – 52 patients with isolated course of vibrational disease. We have used clinical and physiological, ELISA methods to estimate cytokines levels in these patients. We have found that clinical signs of vibrational disease depend on vibrational disease progressing and comorbid pathologies. Overlay of chronic obstructive pulmonary disease to vibra­tional disease significantly worsens disease course, manifested by augmenting of clinical symptoms, neurovascular and trophic violations. Comorbid course of vibrational disease and arterial hypertension leads to respective worsening of cardio-vascular pathology. One of the mechanisms of development and progressing of vibrational disease is imbalance of cytokine chain of immunity — increase of the amount of inflammatory cytokine TNF-α and decrease of anti-inflammatory — IL-10. Overlay of chronic obstructive pulmonary disease enhances this trend. In patients with comorbid course of vibrational disease and arterial hypertension we have observed development of secondary dysregulatory state of immunocompetent system. This is proved by increased levels of inflammatory cytokines (TNF-α by 62.5 % and IL-8 by 46.5 %), and decreased activity of melatonin by 35.0 % in comparison with group of patients with isolated vibrational disease

POTENTIAL OF BUSINESS ENTITIES: ESSENCE, ASSESSMENT AND ROLE IN NATIONAL DEVELOPMENT

The behavior of macroeconomic indicators (reflecting the development of both the national economy as a whole and that of individual economic sectors) testifies to the low current efficiency of the functioning of economic entities in the context of economic activities. This in turn necessitates scientific substantiation of developing and introducing theoretical and methodological recommendations to ensure innovative development of the country. One of the most effective ways to practically implement this task is to substantiate methods for quantitative assessment of potential in the context of economic activities. The practical value of applying these methods is that the results of the integrated assessment of potential can be used as a criterion for the priority development of certain economic sectors or economic activities

Limits on the effective quark radius from inclusive epep scattering at HERA

The high-precision HERA data allows searches up to TeV scales for Beyond the Standard Model contributions to electron-quark scattering. Combined measurements of the inclusive deep inelastic cross sections in neutral and charged current $ep$ scattering corresponding to a luminosity of around 1 fb$^{-1}$ have been used in this analysis. A new approach to the beyond the Standard Model analysis of the inclusive $ep$ data is presented; simultaneous fits of parton distribution functions together with contributions of "new physics" processes were performed. Results are presented considering a finite radius of quarks within the quark form-factor model. The resulting 95% C.L. upper limit on the effective quark radius is $0.43\cdot 10^{-16}$ cm.Comment: 10 pages, 4 figures, accepted by Phys. Lett.

The SHiP experiment at the proposed CERN SPS Beam Dump Facility

The Search for Hidden Particles (SHiP) Collaboration has proposed a general-purpose experimental facility operating in beam-dump mode at the CERN SPS accelerator to search for light, feebly interacting particles. In the baseline configuration, the SHiP experiment incorporates two complementary detectors. The upstream detector is designed for recoil signatures of light dark matter (LDM) scattering and for neutrino physics, in particular with tau neutrinos. It consists of a spectrometer magnet housing a layered detector system with high-density LDM/neutrino target plates, emulsion-film technology and electronic high-precision tracking. The total detector target mass amounts to about eight tonnes. The downstream detector system aims at measuring visible decays of feebly interacting particles to both fully reconstructed final states and to partially reconstructed final states with neutrinos, in a nearly background-free environment. The detector consists of a 50 m long decay volume under vacuum followed by a spectrometer and particle identification system with a rectangular acceptance of 5 m in width and 10 m in height. Using the high-intensity beam of 400 GeV protons, the experiment aims at profiting from the 4 x 10(19) protons per year that are currently unexploited at the SPS, over a period of 5-10 years. This allows probing dark photons, dark scalars and pseudo-scalars, and heavy neutral leptons with GeV-scale masses in the direct searches at sensitivities that largely exceed those of existing and projected experiments. The sensitivity to light dark matter through scattering reaches well below the dark matter relic density limits in the range from a few MeV/c(2) up to 100 MeV-scale masses, and it will be possible to study tau neutrino interactions with unprecedented statistics. This paper describes the SHiP experiment baseline setup and the detector systems, together with performance results from prototypes in test beams, as it was prepared for the 2020 Update of the European Strategy for Particle Physics. The expected detector performance from simulation is summarised at the end

Fast simulation of muons produced at the SHiP experiment using generative adversarial networks

This paper presents a fast approach to simulating muons produced in interactions of the SPS proton beams with the target of the SHiP experiment. The SHiP experiment will be able to search for new long-lived particles produced in a 400 GeV/c SPS proton beam dump and which travel distances between fifty metres and tens of kilometers. The SHiP detector needs to operate under ultra-low background conditions and requires large simulated samples of muon induced background processes. Through the use of Generative Adversarial Networks it is possible to emulate the simulation of the interaction of 400 GeV/c proton beams with the SHiP target, an otherwise computationally intensive process. For the simulation requirements of the SHiP experiment, generative networks are capable of approximating the full simulation of the dense fixed target, offering a speed increase by a factor of Script O(106). To evaluate the performance of such an approach, comparisons of the distributions of reconstructed muon momenta in SHiP's spectrometer between samples using the full simulation and samples produced through generative models are presented. The methods discussed in this paper can be generalised and applied to modelling any non-discrete multi-dimensional distribution

The experimental facility for the Search for Hidden Particles at the CERN SPS

The International School for Advanced Studies (SISSA) logo The International School for Advanced Studies (SISSA) logo The following article is OPEN ACCESS The experimental facility for the Search for Hidden Particles at the CERN SPS C. Ahdida44, R. Albanese14,a, A. Alexandrov14, A. Anokhina39, S. Aoki18, G. Arduini44, E. Atkin38, N. Azorskiy29, J.J. Back54, A. Bagulya32Show full author list Published 25 March 2019 • © 2019 CERN Journal of Instrumentation, Volume 14, March 2019 Download Article PDF References Download PDF 543 Total downloads 7 7 total citations on Dimensions. Article has an altmetric score of 1 Turn on MathJax Share this article Share this content via email Share on Facebook Share on Twitter Share on Google+ Share on Mendeley Article information Abstract The Search for Hidden Particles (SHiP) Collaboration has shown that the CERN SPS accelerator with its 400 GeV/c proton beam offers a unique opportunity to explore the Hidden Sector [1–3]. The proposed experiment is an intensity frontier experiment which is capable of searching for hidden particles through both visible decays and through scattering signatures from recoil of electrons or nuclei. The high-intensity experimental facility developed by the SHiP Collaboration is based on a number of key features and developments which provide the possibility of probing a large part of the parameter space for a wide range of models with light long-lived super-weakly interacting particles with masses up to Script O(10) GeV/c2 in an environment of extremely clean background conditions. This paper describes the proposal for the experimental facility together with the most important feasibility studies. The paper focuses on the challenging new ideas behind the beam extraction and beam delivery, the proton beam dump, and the suppression of beam-induced background

Measurement of the muon flux from 400 GeV/c protons interacting in a thick molybdenum/tungsten target

The SHiP experiment is proposed to search for very weakly interacting particles beyond the Standard Model which are produced in a 400 GeV/c proton beam dump at the CERN SPS. About 1011 muons per spill will be produced in the dump. To design the experiment such that the muon-induced background is minimized, a precise knowledge of the muon spectrum is required. To validate the muon flux generated by our Pythia and GEANT4 based Monte Carlo simulation (FairShip), we have measured the muon flux emanating from a SHiP-like target at the SPS. This target, consisting of 13 interaction lengths of slabs of molybdenum and tungsten, followed by a 2.4 m iron hadron absorber was placed in the H4 400 GeV/c proton beam line. To identify muons and to measure the momentum spectrum, a spectrometer instrumented with drift tubes and a muon tagger were used. During a 3-week period a dataset for analysis corresponding to (3.27±0.07) × 1011 protons on target was recorded. This amounts to approximatively 1% of a SHiP spill

Track reconstruction and matching between emulsion and silicon pixel detectors for the SHiP-charm experiment

In July 2018 an optimization run for the proposed charm cross section measurement for SHiP was performed at the CERN SPS. A heavy, moving target instrumented with nuclear emulsion films followed by a silicon pixel tracker was installed in front of the Goliath magnet at the H4 proton beam-line. Behind the magnet, scintillating-fibre, drift-tube and RPC detectors were placed. The purpose of this run was to validate the measurement's feasibility, to develop the required analysis tools and fine-tune the detector layout. In this paper, we present the track reconstruction in the pixel tracker and the track matching with the moving emulsion detector. The pixel detector performed as expected and it is shown that, after proper alignment, a vertex matching rate of 87% is achieved

Hormonal peculiarities in patients with vibration disease and hypertension

Вплив виробничої вібрації є хронічним стресуючим фактором, що визначає функціонування і перебудову гормональних систем. Однак тривалий вплив гормонів, що беруть участь у формуванні реакції адаптації, обумовлює серйозні порушення в обміні ліпідів, вуглеводів і електролітів і може стати основою для розвитку серцево-судинних захворювань. Метою дослідження було вивчення гормональної ланки імунітету (мелатонін, окситоцин) у хворих на вібраційну хворобу в поєднанні з гіпертонічною хворобою. У дослідження включені 107 хворих з діагнозом вібраційна хвороба І та ІІ ступеня, у 60 хворих вібраційна хвороба поєднувалася з гіпертонічною. Згідно з отриманими даними, у хворих з поєднаним перебігом вібраційної та гіпертонічної хвороби розвивається вторинний дисрегуляторний стан імунокомпетентної сфери. Про це свідчить підвищення рівня окситацину та зниження активності мелатоніну на 35% порівняно з групою хворих на ізольовану вібраційну хворобу. Влияние производственной вибрации является хроническим стрессирующим фактором, определяющим функционирование и перестройку гормональных систем. Однако длительное воздействие гормонов, участвующих в формировании реакции адаптации, обусловливает серьезные нарушения в обмене липидов, углеводов и электролитов и может стать основой для развития сердечно-сосудистых заболеваний. Целью исследования явилось исследование гормонального звена иммунитета (мелатонин, окситоцин) у больных вибрационной болезнью в сочетании с гипертонической болезнью. В исследование включены 107 больных з диагнозом вибрационная болезнь І и ІІ степени, у 60 больных вибрационная болезнь сочеталась с гипертонической. Согласно полученным данным, у больных с сочетанным течением вибрационной и гипертонических болезней развивается вторичное дисрегуляторное состояние иммунокомпетентной сферы. Про это свидетельствует повышение уровня окситацина и снижение активности мелатонина на 35% сравнительно с группой больных с изолированным течением вибрационной болезни. Occupational vibration is regarded as chronic stress factor that determines functioning and remodelling of hormonal systems. However, prolonged effect of hormones involved in the development of adaptive reactions can result in significant disorders of metabolism of lipids, carbohydrates and electrolytes, as well as to cardio-vascular disorders. Affecting smooth muscles of vessels, oxytocin causes vasodilatation, increases circulation through kidneys, coronary vessels and brain vessels. Key role of melatonin is determined by its rhythm controlling that promotes all endogenic body rhythms. Circadian rhythms of arterial hypertension are determined by the role of melatonin in regulating cardio-vascular functions. It has been also proved by presence of melatonin receptors in muscles and vascular endothelium. The aim of this research was to study hormonal chain of immunity (melatonin and oxytocin) in patients with vibration disease (VD) and hypertension. Research included 107 patients with VD from local vibration of I and II stage, aged 41–66, mean age was 54±6.17 years. 60 patients with VD were diagnosed to have hypertension II stage (main group); other 47 had isolated hypertension (comparison group). Every group was subdivided by VD stages. Main group included VD I stage and hypertension II stage (26 persons) and VD II and hypertension II stage (34 persons). Comparison group has been divided into isolated VD I stage (21 persons) and isolated VD II stage (26 persons). Amount of hormones (melatonin and oxytocin) in blood serum was assessed by ELISA with test systems “Melatonin Elisa” (“IBL Hamburg”, Germany), “Correlate‒EIATM Oxitocin” (“Assay Designs”, USA) and ELISA analyzer Star Fax 303 Plus. Statistical analysis was performed using statistical software Statistica 6.1 (StatSoft, Inc., USA). Analysis of research results has showed that vibration effect inhibits the activity of immune system. We have found out a significant decrease in melatonin in the main group (21,97 pg/ml; ME[17,63;25,61] against 30,3 pg/ml. Statistically significant increase in oxytocin (139,6 pg/ml; ME[92,5;169] against 134 pg/ml; ME[62;191]) was only in the group of combined pathology that can be proven by the constriction of peripheral vessels. Effects of these and some other chains of hormonal regulation that form pressor macrosystem, promotes increasing of arterial pressure, and shows the presence of changes in hormonal regulation in patients with VD. According with data patients with VD and hypertension has secondary deregulatory state of immunocompetent field. This has been proven by increased levels of oxytocin and decreasing in activity of melatonin by 35 %, compared with patients having isolated VD