Ginzburg-Landau theory of the cluster glass phase

On the basis of a recent field theory for site-disordered spin glasses a Ginzburg-Landau free energy is proposed to describe the low temperatures glassy phase(s) of site-disordered magnets. The prefactors of the cubic and dominant quartic terms change gradually along the transition line in the concentration-temperature phase diagram. Either of them may vanish at certain points $(c_*, T_*)$, where new transition lines originate. The new phases are classifiedComment: 6 pages Revtex, 5 figures. To appear in J. Phys. A. Let

Concentration dependence of the transition temperature in metallic spin glasses

The dependence of the transition temperature $T_g$ in terms of the concentration of magnetic impurities $c$ in spin glasses is explained on the basis of a screened RKKY interaction. The two observed power laws, $T_g ~ c$ at low $c$ and $T_g ~ c^{2/3}$ for intermediate $c$, are described in a unified approach.Comment: 4 page

Thermodynamics of black holes: an analogy with glasses

The present equilibrium formulation of thermodynamics for black holes has several drawbacks, such as assuming the same temperature for black hole and heat bath. Recently the author formulated non-equilibrium thermodynamics for glassy systems. This approach is applied to black holes, with the cosmic background temperature being the bath temperature, and the Hawking temperature the internal temperature. Both Hawking evaporation and absorption of background radiation are taken into account. It is argued that black holes did not form in the very early universe.Comment: 4 pages revtex; submitted to Phys. Rev. Let

House dust mite induced allergic airway disease is attenuated in CD11ccreIL-4Rα−/l°x mice

Abstract The precise mechanisms leading to development of T helper type (Th)2-driven allergic responses are unknown. We aimed to determine how IL-4 receptor alpha (IL-4Rα) signaling on CD11c+ cells influences allergen-induced Th2 responses in mice. CD11ccreIL-4Rα−/l°x mice, deficient in IL-4Rα on dendritic cells and alveolar macrophages, were compared to IL-4Rα−/l°x littermate controls in models of allergic airway disease induced by OVA/alum, OVA alone or house dust mite. Cytokine responses, eosinophil and neutrophil infiltration into the lungs, airway hyperreactivity and mucus hypersecretion were evaluated after allergen challenge. In the OVA/alum model, CD11ccreIL-4Rα−/lox mice had similar airway hyperreactivity, eosinophil infiltration, Th2-type cytokine production and mucus hypersecretion to littermate controls. When alum was omitted during sensitization, CD11ccreIL-4Rα−/lox mice had similar airway hyperreactivity and mucus secretion but reduced Th2-type cytokine production and eosinophils, suggesting alum overrides the requirement for IL-4Rα signaling on CD11c+ cells in enhancing Th2-type responses. In the house dust mite model, CD11ccreIL-4Rα−/lox mice showed similar mucus secretion, but reduced Th2 responses, eosinophils, neutrophils and airway hyperreactivity, unlike previously tested LysMcreIL-4Rα−/lox mice, which lack IL-4Rα on alveolar macrophages but not on dendritic cells. Therefore, our results indicate that IL-4Rα signaling on dendritic cells promotes allergen-induced Th2 responses and eosinophil infiltration into the lung

Transition from Diffusive to Localized Regimes in Surface Corrugated Optical Waveguides

Exact calculations of the transmittance of surface corrugated optical waveguides are presented. The elastic scattering of diffuse light or other electromagnetic waves from a rough surface induces a diffusive transport along the waveguide axis. As the length of the corrugated part of the waveguide increases, a transition from the diffusive to the localized regime is observed. This involves an analogy with electron conduction in nanowires, and hence, a concept analogous to that of ``resistance'' can be introduced. We show an oscillatory behavior of both the elastic mean free path and the localization length versus the wavelength.Comment: 3 pages, REVTEX, 3 PS figure

Intensity Distribution of Waves Transmitted Through a Multiple Scattering Medium

The distributions of the angular transmission coefficient and of the total transmission are calculated for multiple scattered waves. The calculation is based on a mapping to the distribution of eigenvalues of the transmission matrix. The distributions depend on the profile of the incoming beam. The distribution function of the angular transmission has a stretched exponential decay. The total-transmission distribution grows log-normally whereas it decays exponentially.Comment: 8 pages, revtex3.0, 3 postscript figures, NvR0

Competition between glassiness and order in a multi-spin glass

A mean-field multi-spin interaction spin glass model is analyzed in the presence of a ferromagnetic coupling. The static and dynamical phase diagrams contain four phases (paramagnet, spin glass, ordinary ferromagnet and glassy ferromagnet) and exhibit reentrant behavior. The glassy ferromagnet phase has anomalous dynamical properties. The results are consistent with a nonequilibrium thermodynamics that has been proposed for glasses.Comment: revised version, 4 pages Revtex, 2 eps-figures. Phys. Rev. E, Rapid Communication, to appea

IL-13 Signals Independent of IL-4 Receptor-Alpha Chain to Drive Ovalbumin-Induced Dermatitis

Atopic dermatitis (AD) is an allergic skin condition that can result from intrinsic genetic factors or repetitive occupational damage. Disruption of the skin barrier leads to sensitization to allergens followed by local inflammation (Leung et al., 2004, Pigatto et al., 1992). Strong evidence has shown that the T helper-2 (Th2) cytokine, IL-13, is the dominant disease-causing factor in the pathogenesis of AD in mice (Nieuwenhuizen et al., 2009, Sivaprasad et al., 2010, Tazawa et al., 2004). Hence, it is possible that patients with AD would benefit from treatments specifically targeting IL-13 signaling pathways. However, current treatment strategies are limited to broader therapies, such as emollients, topical glucocorticoids, and calcineurin inhibitors (Beck et al., 2014, De Benedetto et al., 2012, Gittler et al., 2012). A recent study by Beck et al. (2014), which used the monoclonal antibody dupilumab to block IL-4 receptor-alpha (IL-4Rα) signaling, showed promise in targeting specific immunological pathways. Until recently, IL-13 was thought to signal only through the IL-4Rα/IL-13Rα1 complex; however, recent data suggest that IL-13 may also signal via IL-13Rα2, previously known as a decoy receptor. In AD, the signaling pathway of IL-13 remains to be defined. In this study we addressed this problem by using a combination of IL-4Rα–deficient mice that lacked or overexpressed IL-13 to determine if IL-13 can signal independently of the IL-4Rα chain to mediate AD. Our results may have potential implications for therapeutic strategies, such as using IL-4Rα–antagonists to treat the disease.National Research Foundation (South Africa

"Optical conductance fluctuations: diagrammatic analysis in Landauer approach and non-universal effects"

The optical conductance of a multiple scattering medium is the total transmitted light of a diffuse incoming beam. This quantity, very analogous to the electronic conductance, exhibits universal conductance fluctuations. We perform a detailed diagrammatic analysis of these fluctuations. With a Kadanoff-Baym technique all the leading diagrams are systematically generated. A cancellation of the short distance divergencies occurs, that yields a well behaved theory. The analytical form of the fluctuations is calculated and applied to optical systems. Absorption and internal reflections reduce the fluctuations significantly.Comment: 25 pages Revtex 3.0, 18 seperate postscript figure

Properties of Chiral Wilson Loops

We study a class of Wilson Loops in N =4, D=4 Yang-Mills theory belonging to the chiral ring of a N=2, d=1 subalgebra. We show that the expectation value of these loops is independent of their shape. Using properties of the chiral ring, we also show that the expectation value is identically 1. We find the same result for chiral loops in maximally supersymmetric Yang-Mills theory in three, five and six dimensions. In seven dimensions, a generalized Konishi anomaly gives an equation for chiral loops which closely resembles the loop equations of the three dimensional Chern-Simons theory.Comment: 15 pages, two pictures, some references adde