18 research outputs found
Dataset of allele, genotype and haplotype frequencies of of four polymorphisms filaggrin gene in Russian patients with atopic dermatitis
Data on the allele, genotype and haplotype frequencies of four single nucleotide polymorphisms (SNPs) (rs3126085, rs12144049, rs471144 and rs4363385) filaggrin (FLG) gene in Russian patients with atopic dermatitis are presente
ΠΠ»ΠΈΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΠ»ΠΎΠ²ΠΈΠΉ ΠΠ°ΡΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΡΡ Π·Π° ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ 40 Π»Π΅Ρ
The paper discusses air (Ta) and sea surface temperature (SST) year-to-year variability due to warming of the Kara Sea, using the data from regular observations at the meteorological stations Roshydromet (GMS) in 1978β2017, NOAA optimum interpolation and reanalysis data. We use the methods of cluster, correlation analysis and Empirical Orthogonal Functions (EOF). We investigate possible cause and effect relationships of these changes with the variations of the wind field components, climatic indices and the sea ice concentration field. The cluster analysis of the three main EOF components has allowed us to identify four areas on the basis of the nature of changes of the water temperature anomalies field. The climatic changes in these areas, in the coastal and island zones of the Kara Sea have manifested themselves in the steady increase of the annual air temperature at GMS from 0,47β0,77 Β°C/10 years on the southwest coast to 1,33β1,49 Β°C/10 years in the north of the sea. This is equivalent to warming from 1,9 to 6,0 Β°C in the last 40 years. For the open sea the value of the Ta trend is about 1,22 Β°C/10 years, which corresponds to an increase in the average Ta by 4,9 Β°C in the last 40 years. This value is approximately 3 times greater than that for all the Northern hemisphere for the same period.Annualy, the maximal trend was observed in November and April mainly and exceeded 2β3 Β°C/10 years at some of the stations. We identify anomalously warm (2016 and 2012) and anomalously cold (1978, 1979, 1992 and 1998) years: the warmest year was 2012, the coldest β 1979. Positive SST trends were observed over all the sea area during the warm period of year (to 1 Β°C/10 years). SST increased to 2,4 Β°C, which is approximately 1,5 times greater than the corresponding SST values for the Northern hemisphere. The maximum SST trend (0,4 Β°C/10 years) was observed in the northwest and southwest parts of the sea. From June to August the trends of SST exceed the annual ones 1,5β2 times. Interannual SST and Ta variations are characterized by close correlation links. Until approximately 1998β2004 the warming was rather insignificant, and after that the growth rate of Ta and SST increased many fold. Apparently it indicates changes in the mode and the large-scale atmospheric circulation in the early 2000s. We also observed a trend of strengthening of the southern wind during the cold period of the year and the northern one β in the warm period (0,5β0,6 m/s in 40 years). It is shown that there is a close correlation between the Ta increase and the changes in the meridional component of the wind speed during the cold period of the year for all the sea areas. For the warm period it is statistically insignificant both for Ta and SST. For the cold season we observed a contribution of the large-scale mode of atmospheric circulation into the variability of V component of the wind speed. The conribution was expressed through the indeces NAO, SCAND, Pol/EUR, AZOR, ISL and the differences of ISLSIB. For the warm season this contribution is expressed through the NAO, SCAND and AO only. For the warm period we showed statistically significant correlation between the increase in SST, Ta and the processes parametrized by the AMO, EA/WR and AZOR indeces. For the cold period the indeces are AMO, Pol/Eur, SIB and ISL SIB. The interannual variations of the sea ice concentration field are characterized by close correlation with Ta changes both in the annual cycle and during the periods of ice cover formation and evolution (RΒ = β0,7... β0,9). For these periods we showed statistically significant relationships between the first EOF mode fluctuations and two climatic indeces β AMO (RΒ = 0,5) and Pol/Eur (RΒ = 0,4). The relationships between the temporary variability of the sea ice concentration and the wind field characteristics are weaker and statistically significant only for the meridional component of the wind speed (RΒ = β0,4).ΠΠΎ Π΄Π°Π½Π½ΡΠΌ ΡΡΠΎΡΠ½ΡΡ
Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠΉ Π½Π° Π³ΠΈΠ΄ΡΠΎΠΌΠ΅ΡΠ΅ΠΎΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ°Π½ΡΠΈΡΡ
Π ΠΎΡΠ³ΠΈΠ΄ΡΠΎΠΌΠ΅ΡΠ° Π·Π° 1978β2017 Π³Π³., Π΄Π°Π½Π½ΡΡ
ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΡΠΏΠΎΠ»ΡΡΠΈΠΈ ΠΈ ΡΠ΅Π°Π½Π°Π»ΠΈΠ·Π° NOAA Π²ΡΠΏΠΎΠ»Π½Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΌΠ΅ΠΆΠ³ΠΎΠ΄ΠΎΠ²ΠΎΠΉ ΠΈΠ·ΠΌΠ΅Π½ΡΠΈΠ²ΠΎΡΡΠΈ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΠΎΠΉ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ Π²ΠΎΠ΄Ρ ΠΈ Π²ΠΎΠ·Π΄ΡΡ
Π° Π² ΠΠ°ΡΡΠΊΠΎΠΌ ΠΌΠΎΡΠ΅ Π½Π° ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΌ ΡΡΠ°ΠΏΠ΅ ΠΏΠΎΡΠ΅ΠΏΠ»Π΅Π½ΠΈΡ ΠΊΠ»ΠΈΠΌΠ°ΡΠ°. ΠΠ΅ΡΠΎΠ΄Ρ ΠΊΠ»Π°ΡΡΠ΅ΡΠ½ΠΎΠ³ΠΎ, ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΈ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ° ΡΠΌΠΏΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΡΠΎΠ³ΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΉ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅Π½Π½ΠΎ-Π²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΡΡΡΡΠΊΡΡΡΡ ΠΏΠΎΠ»Ρ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ ΠΈ ΡΠ°ΠΉΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π°ΠΊΠ²Π°ΡΠΎΡΠΈΠΈ ΠΏΠΎ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΠΌ ΠΊΠ»ΠΈΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΠ΅ ΠΏΡΠΈΡΠΈΠ½Π½ΠΎ-ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΡΠ²ΡΠ·ΠΈ ΡΡΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Ρ Π²Π°ΡΠΈΠ°ΡΠΈΡΠΌΠΈ ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠΈΡ
ΠΏΠΎΠ»Ρ Π²Π΅ΡΡΠ°, ΠΊΠ»ΠΈΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΈΠ½Π΄Π΅ΠΊΡΠ°ΠΌΠΈ ΠΈ ΡΠΏΠ»ΠΎΡΠ΅Π½Π½ΠΎΡΡΡΡ Π»ΡΠ΄Π°. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΡΠ΄Π°Π»ΠΎΡΡ ΡΡΠΎΡΠ½ΠΈΡΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ ΠΎΡΠ΅Π½ΠΊΡ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΠΉ ΠΈ Π²ΡΡΠ²ΠΈΡΡ ΡΠ΅Π³ΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΠΌΠ΅ΠΆΠ³ΠΎΠ΄ΠΎΠ²ΠΎΠΉ ΠΈΠ·ΠΌΠ΅Π½ΡΠΈΠ²ΠΎΡΡΠΈ ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ»ΠΎΠ²ΠΈΠΉ ΠΠ°ΡΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΡΡ
Analytical and numerical analyses of the micromechanics of soft fibrous connective tissues
State of the art research and treatment of biological tissues require
accurate and efficient methods for describing their mechanical properties.
Indeed, micromechanics motivated approaches provide a systematic method for
elevating relevant data from the microscopic level to the macroscopic one. In
this work the mechanical responses of hyperelastic tissues with one and two
families of collagen fibers are analyzed by application of a new variational
estimate accounting for their histology and the behaviors of their
constituents. The resulting, close form expressions, are used to determine the
overall response of the wall of a healthy human coronary artery. To demonstrate
the accuracy of the proposed method these predictions are compared with
corresponding 3-D finite element simulations of a periodic unit cell of the
tissue with two families of fibers. Throughout, the analytical predictions for
the highly nonlinear and anisotropic tissue are in agreement with the numerical
simulations
Dataset of allele, genotype and haplotype frequencies of five polymorphisms CDKN2B-AS1 gene in Russian patients with primary open-angle glaucoma
Data on the allele, genotype and haplotype frequencies of the five single nucleotide polymorphisms (SNPs) such as rs1063192, rs7865618, rs2157719, rs944800 and rs4977756 of the CDKN2B-AS gene in Russian patients with primary open-angle glaucoma (POAG) are provide
Case of early diagnosis of hereditary thrombophilia in a 16 days child
The article describes a clinical case of early diagnosis of hereditary thrombophilia in a child in the neonatal period, based on clinical, laboratory and genetic examination. Clinical suspicion to hereditary hemostatic disorders, careful analysis of hereditary and family history allowed to identify and confirm with the help of PCR polymorphism of genes associated with hemostatic system in a child of two weeks of age. Early diagnosis allows to make an individual plan of observation and dynamic examination to prevent increased thrombosis and possible vascular catastrophe in the child, to prevent metabolic and hemostatic disorders in both the mother and her relatives, and in the probable future siblings of the patient, and in the long term and in his descendants. Β© 2019 National Academy of Pediatric Science and Innovation. All rights reserved