Dynamics of the formation of a hydrogel by a pathogenic amyloid peptide: islet amyloid polypeptide

Many chronic degenerative diseases result from aggregation of misfolded polypeptides to form amyloids. Many amyloidogenic polypeptides are surfactants and their assembly can be catalysed by hydrophobic-hydrophilic interfaces (an air-water interface in-vitro or membranes in-vivo). We recently demonstrated the specificity of surface-induced amyloidogenesis but the mechanisms of amyloidogenesis and more specifically of adsorption at hydrophobic-hydrophilic interfaces remain poorly understood. Thus, it is critical to determine how amyloidogenic polypeptides behave at interfaces. Here we used surface tensiometry, rheology and electron microscopy to demonstrate the complex dynamics of gelation by full-length human islet amyloid polypeptide (involved in type II diabetes) both in the bulk solution and at hydrophobic-hydrophilic interfaces (air-water interface and phospholipids). We show that the hydrogel consists of a 3D supramolecular network of fibrils. We also assessed the role of solvation and dissected the evolution over time of the assembly processes. Amyloid gelation could have important pathological consequences for membrane integrity and cellular functions

Potential Biases and Social Stigmas Toward Mental Health on Georgia Southern’s Campus

Aims: The purpose of this study is to examine the potential biases and social stigmas toward mental health on Georgia Southern’s campus. The research questions explored are as follows: (1) Are there mental health biases on campus? (2) Are there any differences between college, class status, marital status, race, age, or gender in terms of mental health bias? (3) Do students feel as though there are available resources on campus? (4) Do students feel comfortable reaching out for help? Methods: Data was collected from 350 undergraduate students over the age of 18 via a Likert-style questionnaire. The questionnaire consisted of a total of 27 questions. Results: 94% of participants desired an ability to make an online counseling appointment in a secure manner; 67.4% of participants did not believe that the media accurately represented mental illness; and 64.6% of participants would be more inclined to seek help for a mental illness if friends or family were more accepting. Conclusions: According to the study, it is evident that campus resources could be more accessible to students. It is also evident that students are more inclined to reach out for help and utilize resources if they feel more accepted by their friends or family

Digest: Plant-pathogen coevolution extends to shifts in plant breeding systems

Plants and their pathogens are in a coevolutionary arms race. Some pathogens, such as anther smuts, use their host plants’ pollinators for spore dispersal. In the plant Dianthus pavonius, gynodioecy (having female and hermaphroditic plants) has evolved to reduce flowering duration and therefore limit exposure to anther smut pathogens. Bruns et al. (2018) show that this shift in breeding system has evolved as a disease escape mechanism

Addressing a Blind Spot: Altruistic Fear and Religious Bias Motivated Victimization

Fear of victimization is different than actual victimization but has real consequences for individuals’ behaviors and attitudes. Research on fear of victimization in the United States has typically emphasized individuals’ own fears of experiencing violent, sexual, and property crimes. Yet, some studies suggest that fear of crime for other people whose safety one values – significant others, friends, and children – or altruistic fear is more common and often more intense than one’s personal fear of victimization. While some literature exists on the prevalence of altruistic fear in American households, little is known about altruistic fears specifically rooted in the fear of victimization based on a close family member’s or friend’s religious identity. Additionally, some studies suggest that there is a gendered aspect to altruistic fear, where men and women worry and express their fear for loved ones differently. It is likely that these gendered differences manifest in different ways depending on religious tradition. This paper aims to extend the literature on altruistic fear by applying this phenomenon to hate crime victimization, more specifically the fear of victimization based on religious identity

Digest: Plants adapt under attack: genotypic selection and phenotypic plasticity under herbivore pressure

Plant species adapt to changing environmental conditions through phenotypic plasticity and natural selection. Agrawal et al. (2018) found that dandelions responded to the presence of insect pests by producing higher levels of defensive compounds. This defensive response resulted both from phenotypic plasticity, with individual plants’ defenses triggered by insect attack, and from evolution by natural selection acting on genetic variation in the plant population

Recruiting and retaining children and families' social workers. The potential of work discussion groups

Current difficulties with the recruitment and retention of children and families' social workers have been formally acknowledged. However, although initiatives which focus on remuneration and career progression are clearly welcome, research and evidence from practice highlights how social workers themselves place high value on the availability of good quality supervision. Yet, questions remain about whether first-line managers have the time or are even in the best position to offer this support. This article draws on the experience and evaluation of one particular model of supervision — 'work discussion groups' —and explores its impact with residential social work staff and teachers as well as the potential for further developments of this kind