THE SYNTHESIS OF (5-HYDROXY-5-(1-METHOXYPROPAN-2-YL) -4-METHYLFURAN-2(5H)-ONE, 5-(1-METHOXYPROPAN-2-YL) -4-METHYLFURAN-2(5H)-ONE) AND BIOLOGICAL ACTIVITY

<p>Butenolides are a class of <a title="Lactone" href="http://en.wikipedia.org/wiki/Lactone">lactones</a> with a four <a title="Carbon" href="http://en.wikipedia.org/wiki/Carbon">carbon</a> <a title="Heterocycle" href="http://en.wikipedia.org/wiki/Heterocycle">heterocyclic</a> ring structure.  </p><p>They are sometimes considered as <a title="Redox" href="http://en.wikipedia.org/wiki/Redox">oxidized</a> derivatives of <a title="Furan" href="http://en.wikipedia.org/wiki/Furan">furan</a>. The simplest butenolide is <a title="2-furanone" href="http://en.wikipedia.org/wiki/2-furanone">2-furanone</a>, which is a common component of larger <a title="Natural product" href="http://en.wikipedia.org/wiki/Natural_product">natural products</a> and is sometimes referred to as simply "butenolide". A common <a title="Biochemistry" href="http://en.wikipedia.org/wiki/Biochemistry">biochemically</a> important butenolide is <a title="Ascorbic acid" href="http://en.wikipedia.org/wiki/Ascorbic_acid">ascorbic acid</a></p><p>(vitamin C).</p><p>The butenolide and their analogues represent a wide range of the natural compounds of medical and biological importance.</p><p>In the last decades, a great number of compounds of various structures, in general from Alkylidene butenolide were isolated and showed biological activities.</p><p>In this work we have studied the reactivity of some alkylidene butenolide and carried out their antibacterial activity.</p

REINVESTIGATION OF ESSENTIAL OIL CONTENT OF THAPSIA GARGANICA GROWN IN THE EAST OF ALGERIA

<em>Thapsia garganica</em> is a very famous medicinal plant known especially for its therapeutic effects such as diuretic, emetic and purgative. A resin is extracted with alcohol from the bark of the root. The plant has been considered specific in treating pain, though caution is advised since it is poisonous to some mammals. The plant is also strongly rubefacient, producing blisters and intense itching. In the present study, we have undertaken a Reinvestigation of essential oil content of this widely used plant because of its important bioactive effect to heal many ailments

Role of hydroxypropylmethylcellulose (HPMC 4000) in the protection of the polymorphs of Piroxicam extended release tablets

The present study deals with the influence of hydroxypropylmethylcellulose 4000 in the protection of Piroxicam polymorphs which could appear during the processes of formulation of extended release tablets. The physico-chemical tests and the dissolution profiles of polymorphs and tablets showed that the metolose incorporated in the tablets at a rate equivalent to 5% could possibly act doubly; initially by protecting the piroxicam polymorphism transition (form II) during compression, then modulating its in vitro release (extended release)

PHYTOCHEMICAL ANALYSIS, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF LEAVES EXTRACT OF DATE PALM GROWN IN ALGERIA

In this study, we have determined the phenolic compounds, antioxidant and antimicrobial activity of methanolic extracts from three varieties of leaves tree. According to the results the leaves extracts have very important values for polyphenols (215.24 to 156.46 mg GAE / g DW) and high antioxidant activity (324. 45 to 206.21 mg GAE / g DW), DPPH (IC50 = 2.98 to 4.83 μg / ml) and β-bleaching test (IC50 = 133. 93 to 194. 12 μg / ml); also the three extracts reveal a considerable antimicrobial potency and antifungal considerable activity , the diameter of inhibition is 14.4 ± 0.6 mm for Hamraya, 19.8 ± 0.5 mm for Ghars and 17.4 ± 0.8 mm for Deglet Nour (concentration 50 mg / ml) from Staphylococcus aureus ATCC

INHIBITION EFFECT OF FLAVONOID EXTRACT OF Euphorbia Guyoniana ON THE CORROSION OF MILD STEEL IN H2SO4 MEDIUM

<p>The influence of flavonoids extracts of three parts of <em>Euphorbia Guyoniana</em> towards the corrosion of type API 5L X52 steel in 15% H₂SO₄ has been evaluated by weight loss method and polarization technique. The results showed that extracts are a good inhibitors for API 5L X52 steel in this medium. The corrosion inhibition efficiency increases on increasing plant extracts concentration. The inhibition is attributed to the adsorption of the surface of the metal. Potentiodynamic polarization results revealed that the studied inhibitors behave as a mixed type.</p

Effect of growth stage on yield and essential oil composition of Daucus sahariensis

The essential oils obtained by hydrodistillation from Daucus sahariensis Murb. harvested at three different growth stages were characterized by GC/MS analysis. In total, 88 compounds were identified, with myristicin (29.8–51.7%), myrcene (6.7–31.1%), a-pinene (11.6–14.8%), and limonene (5.3 – 11.5%) as main constituents. Monoterpene hydrocarbons were the most represented compounds in the oils of the plant samples collected during the flower-budding and full-flowering periods. On the contrary, during the fruiting stage, the oils were dominated by phenylpropanoids. The essential oils were subject of considerable variation in their composition during the various developmental stages, particularly concerning the content of myrcene that decreased significantly passing from the vegetative to the fruiting stage. Conversely, for myristicin, the opposite trend was observed. Furthermore, the essential-oil yields were quite low during the flower-budding phase (0.27%), but rapidly increased during plant development (0.63 and 0.68% for the flowering and fruiting phases, resp.

Design of Dye-Sensitized Solar triphenodioxazine using TiO2 as a semiconductor

The present work deals with the synthesis of multichromophores which strongly absorb the solar spectrum to functionalize the nanoparticle oxide semiconductor used in the hybrid cells. At first, we developed a material that forms a chromophore triphenodioxazine. We obtained some triphenodioxazines with high yields up to 70 percent. On the other hand, we have carried out many tests such as UV-Visible, Cyclic voltammetry for our molecules to check their electronic and optical properties. The results confirmed that these chromophores meet the criteria for use in photovoltaic cells. Finally, we have successfully realized photovoltaic cells with triphenodioxazine. The findings were very interesting since the photovoltaic conversion efficiencies ranged from 4.30% to 6.30%. The new synthesis strategy of these chromophores opens a way for the development of organic materials used for photovoltaics

Essential oil content of the flowers of Pituranthos scoparius in Algeria

The essential oils obtained by hydrodistillation of the flowers of the Algerian Pituranthos scoparius (Coss. & Dur.)Benth.et Hook. (Apiaceae), an endemic species of North Africa, were analyzed by GC-MS. Thirty-one compounds were identified accounting for 99.3 % of the whole essential oil, mainly represented by monoterpenes, followed by phenylpropanoid derivatives. The main constituents of the essential oil were myristicin (24.1%), α-pinene (17.4%), α-phellandrene (15.6%) and sabinene (7.5%