4,389 research outputs found
Decrease of vanillin sucrose intake by victorious and defeated mice: development of anhedonia?
Hedonic reactions to various rewards play a key role in various forms of motivated behavior. The influence of repeated experience of social victories or defeats in daily agonistic interactions between male mice on voluntary consumption of vanillin sucrose solution used as hedonic reinforcer was studied. Intake of vanillin sucrose solution was shown to decrease in the winners and losers exposed to social confrontations as compared with the controls. Three days of deprivation failed to restore the intake of vanillin sucrose solution to the control level in the losers and did so in the winners. The results obtained imply that similar reaction of animals to a hedonic non-drug reinforcer may have different motivational origin depending on positive or negative social experience
Application of the Sensory Contact Model for Pharmacological Studies under Simulated Clinical Conditions
The sensory contact model allows forming different psycho-pathological states (anxious depression, catalepsy, social withdrawal, pathological aggression, cognition disturbances, anhedonia, addictive states etc.) produced by repeated agonistic interactions in male mice and investigating the therapeutic and preventive properties of any drug as well as its efficiency under simulated clinical conditions. This approach can be useful for a better understanding of the drugs’ action in different stages of disease development in individuals. It is suggested that this behavioral approach and pharmacological designs may be applied for the screening of novel psychotropic drugs. 

Anhedonia in the shadow of chronic social defeat stress, or When the experimental context matters
One of the core symptoms of major depression in human is anhedonia. For that reason, one of the main requirements towards experimental depression models is that they be able to demonstrate anhedonia in animals, that have been exposed to stressful events, and other behavioral changes attributable to a depression-like state. However, the results presented in the literature are contradictory: sweet solution intake, which is considered as a parameter of hedonic/anhedonic behavior in animals, responds quite differently to stressful situations in that it is either unaffected or increased or decreased. Different experimental designs used for the study of anhedonia in male mice exposed to chronic social defeat stress were tried to understand the reasons for so contradictory responses. Anhedonia appears as an abrupt reduction in sweet solution consumption in stressed animals and by failure to attain recovery after deprivation. However, it was also demonstrated that sucrose solution intake and preference strongly depend on the experimental context; that the possible critical factor may be prior acquaintance with the hedonic stimulus – or the lack whereof. Analysis of literature data and ours allowed us to conclude that the lack of a significant decrease in sweet solution intake in stressed animals is no evidence of lack of depression. This decrease is evidence of anhedonia only provided other symptoms of depression are present. Hedonic consumable intake can be decreased over various motivations, conditions or diseases, in particular, a high level of anxiety or pathological aggression
Results of Radiation Tests of the Anode Front-End Boards for the CMS Endcap Muon Cathode Strip Chambers
Phase diagram of YBaCuO at TT based on Cu(2) transverse nuclear relaxation
Two maxima in transverse relaxation rate of Cu(2) nuclei in
YBaCuO are observed, at T = 35 K and T = 47 K. Comparison of
the Cu(2) and Cu(2) rates at T = 47 K indicates the magnetic
character of relaxation. The enhancement at T = 47 K of fluctuating local
magnetic fields perpendicular to the CuO planes is connected with the
critical fluctuations of orbital currents. Maximum at T = 35 K is connected
with the appearance of inhomogeneous supeconducting phase. Together with data
published to date, our experimental results allow to suggest a qualitatively
new phase diagram of the superconducting phase.Comment: 4 LaTEX pages + 3 figures in *.ps forma
FAVOR (FAst Variability Optical Registration) -- A Two-telescope Complex for Detection and Investigation of Short Optical Transients
An astronomical complex intended to detect optical transients (OTs) in a wide
field and follow them up with high time resolution investigation is described.Comment: 4 pages, 3 figures. To be published in "Il Nuovo Cimento",
Proceedings of the 4th Rome Workshop on Gamma-Ray Bursts in the Afterglow
Era, eds. L. Piro, L. Amati, S. Covino, B. Gendr
Large-Mass Ultra-Low Noise Germanium Detectors: Performance and Applications in Neutrino and Astroparticle Physics
A new type of radiation detector, a p-type modified electrode germanium
diode, is presented. The prototype displays, for the first time, a combination
of features (mass, energy threshold and background expectation) required for a
measurement of coherent neutrino-nucleus scattering in a nuclear reactor
experiment. The device hybridizes the mass and energy resolution of a
conventional HPGe coaxial gamma spectrometer with the low electronic noise and
threshold of a small x-ray semiconductor detector, also displaying an intrinsic
ability to distinguish multiple from single-site particle interactions. The
present performance of the prototype and possible further improvements are
discussed, as well as other applications for this new type of device in
neutrino and astroparticle physics (double-beta decay, neutrino magnetic moment
and WIMP searches).Comment: submitted to Phys. Rev.
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