Odnos između azbestnih telašaca, serumskih imunoglobulina i rentgenografskih promena kod radnika u azbestnoj industriji

In this study 52 workers from an asbestos factory were examined. They were placed in three groups: Group 1, directly exposed to asbestos with X-ray changes of the lungs indicative of asbestosis, Group 2 also directly exposed to asbestos, but without X-ray changes, and Group 3 not directly exposed to asbestos. The lungs and pleura of all the examined workers were X-rayed in the anteroposterior projection. Sputum samples were taken to determine the presence of asbestos bodies, and the level of immunoglobulins (IgG, IgM and IgA) was determined in sera. In workers exposed to asbestos, a correlation between the number of asbestos bodies and X-ray changes was not found. The level of immunoglobulins in Group 1 workers was significantly higher than in Groups 2 and 3. In the former group, there were significantly more workers with increased IgG level than in the latter groups.Ispitivanja su obuhvatila 52 radnika azbestnog pogona podeljena u tri grupe (I grupa radnika, direktno izloženih azbestu, sa rendgenografskim promenama u smislu azbestoze, II grupa takođe direktno izloženih radnika bez RDG pramena i III grupa radnika koji nisu direktno izloženi azbestu). Svim ispitivanim radnicima napravljena je rendgenografija pluća i pleure, određivan je broj azbestnih telašaca u sputumu i nivo serumskih imunoglobulina (IgG, IgM i IgA). Kod ispitivane grupe azbestnih radnika izloženih azbestu nije utvrđena povezanost između broja azbestnih telašaca u sputumu sa RDG promenama i imunološkim statusom. Utvrđen je statistički značajno viši nivo imunoglobulina G kod I grupe radnika u odnosu na II i III grupu prethodno kategoriziranih radnika. Signifikantno je veći broj radnika I grupe sa povećanim nivoom IgG

Hipersenzitivnost i respiratorna funkcija kod radnika u drvnoj industriji

Ventilatory functions and skin hypersensitivity to allergens present in the wood industry were assessed in 47 workers with an average exposure of 12.8 years. On the basis of the MRC questionnaire for respiratory symptoms, each worker was submitted to the measurements of ventilatory lung function parameters for acute and chronic effects of exposure. Intradermal testing with five specific dust allergens was performed, and the level of serum immunoglobulins was determined. Fifty-five per cent of the workers were found to be hypersensitive to specific allergens. In those with positive skin tests, acute and chronic effects of wood dust on FEF75-85% and PVC were noted, which points to a possible constrictive effect of wood dust localized mostly in the small airways in sensitized persons.Kod 47 radnika drvne industrije sprovedena su ispitivanja u cilju procene senzibilizacije sa specifičnim alergenima i ventilatorne funkcije. Svim ispitivanim osobama popunjavan je MRC upitnik za respiratornu simptomatologiju, određivan je akutni i hronični efekt drvne prašine na ventilatornu funkciju (na njene pojedine parametre) izvršeno je intradermalno testiranje sa pet specifičnih alergena drvne industrije i određivan je nivo serumskih IgG, M i A. Ispitivanja su pokazala senzibilizaciju na specifične alergene kod 55,3% radnika intradermalnim testiranjem. Kod radnika sa pozitivnim intradermalnim testovima registrovan je i akutan i hroničan efekt drvne prašine na parametar FEF75-85% od FVK-a. Ovo ukazuje na eventualni mogući konstriktorni efekat drvne prašine, pretežno lokaliziran u malim disajnim putevima kod senzibiliziranih osoba

Hipersenzitivnost i respiratorna funkcija kod radnika u drvnoj industriji

Ventilatory functions and skin hypersensitivity to allergens present in the wood industry were assessed in 47 workers with an average exposure of 12.8 years. On the basis of the MRC questionnaire for respiratory symptoms, each worker was submitted to the measurements of ventilatory lung function parameters for acute and chronic effects of exposure. Intradermal testing with five specific dust allergens was performed, and the level of serum immunoglobulins was determined. Fifty-five per cent of the workers were found to be hypersensitive to specific allergens. In those with positive skin tests, acute and chronic effects of wood dust on FEF75-85% and PVC were noted, which points to a possible constrictive effect of wood dust localized mostly in the small airways in sensitized persons.Kod 47 radnika drvne industrije sprovedena su ispitivanja u cilju procene senzibilizacije sa specifičnim alergenima i ventilatorne funkcije. Svim ispitivanim osobama popunjavan je MRC upitnik za respiratornu simptomatologiju, određivan je akutni i hronični efekt drvne prašine na ventilatornu funkciju (na njene pojedine parametre) izvršeno je intradermalno testiranje sa pet specifičnih alergena drvne industrije i određivan je nivo serumskih IgG, M i A. Ispitivanja su pokazala senzibilizaciju na specifične alergene kod 55,3% radnika intradermalnim testiranjem. Kod radnika sa pozitivnim intradermalnim testovima registrovan je i akutan i hroničan efekt drvne prašine na parametar FEF75-85% od FVK-a. Ovo ukazuje na eventualni mogući konstriktorni efekat drvne prašine, pretežno lokaliziran u malim disajnim putevima kod senzibiliziranih osoba