First observation of Cherenkov rings with a large area CsI-TGEM-based RICH prototype

We have built a RICH detector prototype consisting of a liquid C6F14 radiator and six triple Thick Gaseous Electron Multipliers (TGEMs), each of them having an active area of 10x10 cm2. One triple TGEM has been placed behind the liquid radiator in order to detect the beam particles, whereas the other five have been positioned around the central one at a distance to collect the Cherenkov photons. The upstream electrode of each of the TGEM stacks has been coated with a 0.4 micron thick CsI layer. In this paper, we will present the results from a series of laboratory tests with this prototype carried out using UV light, 6 keV photons from 55Fe and electrons from 90Sr as well as recent results of tests with a beam of charged pions where for the first time Cherenkov Ring images have been successfully recorded with TGEM photodetectors. The achieved results prove the feasibility of building a large area Cherenkov detector consisting of a matrix of TGEMs.Comment: Presented at the International Conference NDIP-11, Lyon,July201

DBSolve Optimum: a software package for kinetic modeling which allows dynamic visualization of simulation results

<p>Abstract</p> <p>Background</p> <p>Systems biology research and applications require creation, validation, extensive usage of mathematical models and visualization of simulation results by end-users. Our goal is to develop novel method for visualization of simulation results and implement it in simulation software package equipped with the sophisticated mathematical and computational techniques for model development, verification and parameter fitting.</p> <p>Results</p> <p>We present mathematical simulation workbench DBSolve Optimum which is significantly improved and extended successor of well known simulation software DBSolve5. Concept of "dynamic visualization" of simulation results has been developed and implemented in DBSolve Optimum. In framework of the concept graphical objects representing metabolite concentrations and reactions change their volume and shape in accordance to simulation results. This technique is applied to visualize both kinetic response of the model and dependence of its steady state on parameter. The use of the dynamic visualization is illustrated with kinetic model of the Krebs cycle.</p> <p>Conclusion</p> <p>DBSolve Optimum is a user friendly simulation software package that enables to simplify the construction, verification, analysis and visualization of kinetic models. Dynamic visualization tool implemented in the software allows user to animate simulation results and, thereby, present them in more comprehensible mode. DBSolve Optimum and built-in dynamic visualization module is free for both academic and commercial use. It can be downloaded directly from <url>http://www.insysbio.ru</url>.</p

Experimental observation of superradiance in millimeter-wave band

The first experimental results of the observation of superradiance from a single subnanosecond electron bunch are presented. Superradiance was associated with different varieties of stimulated emission (bremstruhlung, cyclotron, Cherenkov, etc). Unique megawatt power level microwave pulses of short duration (0.3-0.5 ns) have been obtained

VHMPID: a new detector for the ALICE experiment at LHC

This article presents the basic idea of VHMPID, an upgrade detector for the ALICE experiment at LHC, CERN. The main goal of this detector is to extend the particle identification capabilities of ALICE to give more insight into the evolution of the hot and dense matter created in Pb-Pb collisions. Starting from the physics motivations and working principles the challenges and current status of development is detailed.Comment: 4 pages, 6 figures. To be published in EPJ Web of Conference

THE ALTERNATIVE APPROACH FOR PACING LEADS IMPLANTATION AND EXTRACTION

Analysingthe example of unusual case of a successful direct constant His bundle pacing, we would like to draw specialist’s attention to details of procedure and some important electrophysiological particularities we have come across during operation. Long-term (7 years) results ( pacing options, ECG data, changes of left ventricle ejection fraction and patient’s quality of life) were considered too

FIRST EXPERIENCE OF DIRECT CONSTANT HIS BUNDLE PACING

Objective: to study electrophysiological parameters and clinical results of direct constant His bundle pacing (HBP). Materials and methods: we examined 36 patients, divided into 2 equal groups (of 18 patients) according to the type of pacing. Group 1 included patients with atrial lead delivery and group 2with ventricle lead delivery. Within 12 months after implantation of the pacemaker were evaluated pacing options, ECG data, changes in heart cavities sizes, quality of life assessments with the MOS SF-36. Results: it turned out that in group 1 QRS duration was 111±13 ms, whereas QRS duration in group 2 was 134±19 ms. So QRS duration and morphology corresponded to physiological and excluded uprising of ventricle dyssynchrony, LV diastolic dysfunction and chronic heart insufficiency, quality of life were higher for group 1 paients : 71±8,5 whereas 63±9,9 in group 2. Conclusions: implantation atrial lead in His-bundle provides more reliable fixation, less early dislocation risk in early postoperative period and facilitates lead extraction. Clinical implementation of this method will contribute Russian industry, which is especially important in import substitution conditions, to the creation of special lead, delivery system and DDDR pacemaker with a backup ventricle channel