SEVERITY INDEX IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Objective: to assess the clinical and prognostic informative values of SI in patients with SLE.Subjects and methods. One hundred and forty-six male patients aged 15 to 64 years with a valid diagnosis of SLE who had been followed up for 15 years were assessed. The patients underwent conventional clinical, laboratory, and instrumental investigations using the standard methods of disease activity assessment. SI and SLICC/ACR Damage Index (SDI) were used to characterize the course and outcomes of SLE. The SI and SDI were analyzed in 133, 91, and 63 patients over time at 1, 5, and 10 years of the disease, respectively.Results. Significant correlations were found between the SI on study inclusion and the indices reflecting the course and activity of SLE. Analysis of changes in SLE indicated that its maximum increase during the first 5 years of the disease was observed in patients aged < 20 years at the onset of SLE. The patients who had SLE concurrent with secondaryantiphospholipid syndrome showed a more marked SI rise than those without these abnormalities. The highest survival rates were noted in patients with an early SI of 0.Conclusion. SI is a good indicator reflecting the accumulated activity of the disease. It increases with longer disease duration; moreover, its rise may occur at any disease stages. This trend depends on the form of the disease, the time of diagnosis, and the presence of comorbidity. SI correlates well with the activity and damage indices traditionally used in SLE and with the frequency of exacerbations, suggesting that SI may be used as a prognostic marker

Information model of production system management

Improvement of production systems of the organization is carried out through the introduction of quality management systems, changes in the model of production organization, the use of modern approaches to improve product quality and customer satisfaction. Measurement, evaluation and analysis of the production system allows to set the direction of activity to improve production processes and to develop activities aimed at ensuring the effectiveness of the whole system. The production system is an open system, it is connected and exchanged with the external environment information, resources, etc. the production system is Called the operating system, which consists of three subsystems: processing subsystem, directly related to the technological processes of raw materials and semi-finished products conversion into finished products; support subsystem, which performs auxiliary functions necessary for the implementation of the main technological processes; planning and control subsystems that receive and process information from the internal and external environment of the organization. The task of building an automated information system is connected with the need to integrate with the subsystem of data collection and analysis, visual representation of information for decision-making at all levels. Building an information management system of the production system is impossible without a powerful infrastructure, without a single information system support and process control. The proposed information system will help to automate the processes of management of the organization, quickly form the strategic and tactical goals of the organization. Within a given period of time, data will be collected and analyzed from the internal and external environment, timely analysis of deviations of the values of indicators from the planned values. The results of information processing will be timely visualized both for each employee and the production system of the organization as a whole