911 research outputs found
Comprehension, mapping and reporting of climate-related risks among listed ïŹrms in Sweden
We study the comprehension, mapping, and reporting of climate-related risks among firms listed on the NasdaqOMX stock exchange in Stockholm. Our study contains two parts: i) a study on the firmsâ external communication through their annual reports, sustainability reports and webpages, and ii) a follow-up survey addressed to each firmâs management team. We find that firms are likely to engage in some form of mapping and reporting of climate-related risks. However, their comprehension of the nature of these risks, underlying problems, and what a climate transition implies varies across firms and industries. There are also substantial variations in the method employed to map and report climate- related risks. Our results further suggest that firms use the Task Force on Climate-related Financial Disclosuresâ recommendations (TCFD) on how to map and report climate risks as a learning tool to improve their climate-risk management. However, as a voluntary initiative it is insufficient to generate substantial change. Consequently, policymakers should focus on improving firmsâ comprehension of what constitutes a climate-risk, how to map such risks and how to report them. The mapping and reporting of climate-related risk may otherwise prove an inefficient tool to redirect and accelerate investments promoting a low-carbon and climate-resilient economy
Conformal anomaly of Wilson surface observables - a field theoretical computation
We make an exact field theoretical computation of the conformal anomaly for
two-dimensional submanifold observables. By including a scalar field in the
definition for the Wilson surface, as appropriate for a spontaneously broken
A_1 theory, we get a conformal anomaly which is such that N times it is equal
to the anomaly that was computed in hep-th/9901021 in the large N limit and
which relied on the AdS-CFT correspondence. We also show how the spherical
surface observable can be expressed as a conformal anomaly.Comment: 18 pages, V3: an `i' dropped in the Wilson surface, overall
normalization and misprints corrected, V4: overall normalization factor
corrected, references adde
Exercise-induced respiratory symptoms are not always asthma
AbstractEighty-eight patients with a history of exercise-induced respiratory symptoms performed a maximal exercise test in order to study the reasons for stopping the test. There was a wide range of percentage maximal fall in peak expiratory flow (PEF), from minus 3% to 63%, mean 11%, recorded 0â30 min, mean 12 min after the break. In the controls the maximal decrease was 0â16%, mean 6%. Diagnostic criteria for asthma were fulfilled by 48 patients (55%). Of these patients 42% had a fall in PEF â„ 15% (exercise-induced asthma). Of the non-asthma patients 10% had a fall â„ 15%. The most common reason for stopping the exercise in the asthma group was breathing troubles (46%), the most common reason in the non-asthma group was chest pain/discomfort (35%). In about 20% of the patients dizziness and/or pricking sensations in arms or legs indicated hyperventilation as an additional reason for stopping the exercise. It is concluded that other kinds of reaction, than bronchial obstruction such as breathing troubles not directly related to bronchial obstruction and chest pain, may be important factors that can restrict physical capacity in patients with exercise-induced respiratory symptoms
On instantons as Kaluza-Klein modes of M5-branes
Instantons and W-bosons in 5d maximally supersymmetric Yang-Mills theory
arise from a circle compactification of the 6d (2,0) theory as Kaluza-Klein
modes and winding self-dual strings, respectively. We study an index which
counts BPS instantons with electric charges in Coulomb and symmetric phases. We
first prove the existence of unique threshold bound state of (noncommutative)
U(1) instantons for any instanton number, and also show that charged instantons
in the Coulomb phase correctly give the degeneracy of SU(2) self-dual strings.
By studying SU(N) self-dual strings in the Coulomb phase, we find novel
momentum-carrying degrees on the worldsheet. The total number of these degrees
equals the anomaly coefficient of SU(N) (2,0) theory. We finally show that our
index can be used to study the symmetric phase of this theory, and provide an
interpretation as the superconformal index of the sigma model on instanton
moduli space.Comment: 54 pages, 2 figures. v2: references added, figure improved, added
comments on self-dual string anomaly, added new materials on the symmetric
phase index, other minor correction
Genuine Counterfactual Communication with a Nanophotonic Processor
In standard communication information is carried by particles or waves.
Counterintuitively, in counterfactual communication particles and information
can travel in opposite directions. The quantum Zeno effect allows Bob to
transmit a message to Alice by encoding information in particles he never
interacts with. The first suggested protocol not only required thousands of
ideal optical components, but also resulted in a so-called "weak trace" of the
particles having travelled from Bob to Alice, calling the scalability and
counterfactuality of previous proposals and experiments into question. Here we
overcome these challenges, implementing a new protocol in a programmable
nanophotonic processor, based on reconfigurable silicon-on-insulator waveguides
that operate at telecom wavelengths. This, together with our telecom
single-photon source and highly-efficient superconducting nanowire
single-photon detectors, provides a versatile and stable platform for a
high-fidelity implementation of genuinely trace-free counterfactual
communication, allowing us to actively tune the number of steps in the Zeno
measurement, and achieve a bit error probability below 1%, with neither
post-selection nor a weak trace. Our demonstration shows how our programmable
nanophotonic processor could be applied to more complex counterfactual tasks
and quantum information protocols.Comment: 6 pages, 4 figure
Open membranes, ribbons and deformed Schild strings
We analyze open membranes immersed in a magnetic three-form field-strength
. While cylindrical membranes in the absence of behave like tensionless
strings, when the flux is present the strings polarize into thin membrane
ribbons, locally orthogonal to the momentum density, thus providing the strings
with an effective tension. The effective dynamics of the ribbons can be
described by a simple deformation of the Schild action for null strings.
Interactions become non-local due to the polarization, and lead to a
deformation of the string field theory, whereby string vertices receive a phase
factor proportional to the volume swept out by the ribbons. In a particular
limit, this reduces to the non-commutative loop space found previously.Comment: revte
Cost-effectiveness of alternative methods of surgical repair of inguinal hernia
Objectives: To assess the relative cost-effectiveness of laparoscopic methods of inguinal hernia repair compared with open flat mesh and open non-mesh repair. Methods: Data on the effectiveness of these alternatives came from three systematic reviews comparing: (i) laparoscopic methods with open flat mesh or non-mesh methods; (ii) open flat mesh with open non-mesh repair; and (iii) methods that used synthetic mesh to repair the hernia defect with those that did not. Data on costs were obtained from the authors of economic evaluations previously conducted alongside trials included in the reviews. A Markov model was used to model cost-effectiveness for a five-year period after the initial operation. The outcomes of the model were presented using a balance sheet approach and as cost per hernia recurrence avoided and cost per extra day at usual activities. Results: Open flat mesh was the most cost-effective method of preventing recurrences. Laparoscopic repair provided a shorter period of convalescence and less long-term pain compared with open flat mesh but was more costly. The mean incremental cost per additional day back at usual activities compared with open flat mesh was âŹ38 and âŹ80 for totally extraperitoneal and transabdominal preperitoneal repair, respectively. Conclusions: Laparoscopic repair is not cost-effective compared with open flat mesh repair in terms of cost per recurrence avoided. Decisions about the use of laparoscopic repair depend on whether the benefits (reduced pain and earlier return to usual activities) outweigh the extra costs and intraoperative risks. On the evidence presented here, these extra costs are unlikely to be offset by the short-term benefits of laparoscopic repair.Luke Vale, Adrian Grant, Kirsty McCormack, Neil W. Scott and the EU Hernia Trialists Collaboratio
The New âHidden Abodeâ: Reflections on Value and Labour in the New Economy
In a pivotal section of Capital, volume 1, Marx (1976: 279) notes that, in order to understand the capitalist production of value, we must descend into the âhidden abode of productionâ: the site of the labour process conducted within an employment relationship. In this paper we argue that by remaining wedded to an analysis of labour that is confined to the employment relationship, Labour Process Theory (LPT) has missed a fundamental shift in the location of value production in contemporary capitalism. We examine this shift through the work of Autonomist Marxists like Hardt and Negri, Lazaratto and Arvidsson, who offer theoretical leverage to prize open a new âhidden abodeâ outside employment, for example in the âproduction of organizationâ and in consumption. Although they can open up this new âhidden abodeâ, without LPT's fine-grained analysis of control/resistance, indeterminacy and structured antagonism, these theorists risk succumbing to empirically naive claims about the ânew economyâ. Through developing an expanded conception of a ânew hidden abodeâ of production, the paper demarcates an analytical space in which both LPT and Autonomist Marxism can expand and develop their understanding of labour and value production in today's economy. </jats:p
An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomes.
BACKGROUND: Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) are heterogeneous with respect to biological behaviour and prognosis. As angiogenesis is a renowned pathogenic hallmark as well as a therapeutic target, we aimed to investigate the prognostic and clinico-pathological role of tissue markers of hypoxia and angiogenesis in GEP-NETs. METHODS: Tissue microarray (TMA) blocks were constructed with 86 tumours diagnosed from 1988 to 2010. Tissue microarray sections were immunostained for hypoxia inducible factor 1α (Hif-1α), vascular endothelial growth factor-A (VEGF-A), carbonic anhydrase IX (Ca-IX) and somatostatin receptors (SSTR) 1â5, Ki-67 and CD31. Biomarker expression was correlated with clinico-pathological variables and tested for survival prediction using KaplanâMeier and Cox regression methods. RESULTS: Eighty-six consecutive cases were included: 51% male, median age 51 (range 16â82), 68% presenting with a pancreatic primary, 95% well differentiated, 51% metastatic. Higher grading (P=0.03), advanced stage (P<0.001), high Hif-1α and low SSTR-2 expression (P=0.03) predicted for shorter overall survival (OS) on univariate analyses. Stage, SSTR-2 and Hif-1α expression were confirmed as multivariate predictors of OS. Median OS for patients with SSTR-2+/Hif-1α-tumours was not reached after median follow up of 8.8 years, whereas SSTR-2-/Hif-1α+ GEP-NETs had a median survival of only 4.2 years (P=0.006). CONCLUSION: We have identified a coherent expression signature by immunohistochemistry that can be used for patient stratification and to optimise treatment decisions in GEP-NETs independently from stage and grading. Tumours with preserved SSTR-2 and low Hif-1α expression have an indolent phenotype and may be offered less aggressive management and less stringent follow up
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