LONG-TERM PROGNOSIS IN PATIENTS WITH A LOCAL BREAST CANCER RELAPSE AFTER ORGAN-SAVING TREATMENT

The paper presents the results of a follow-up of 861 patients who have undergone organ-saving treatment (OST) for early breast can- cer. The relapse rate was 7.3% (63/861). The main task was to study an association of survival rates with the predictors characteriz- ing a local relapse. Five-year overall survival after the start of treatment for a local relapse was 65.7% (standard error 8.3). A Cox multivariance regression analysis led to the conclusion that the local relapse is a statistically significant factor of worsening survival without distant metastases when it develops within 3 years after primary OST

PREDICTORS OF A LOCAL RECURRENCE AFTER ORGAN-PRESERVING TREATMENT FOR EARLY BREAST CANCER: STATE-OF-THE-ART

There are currently many unsolved problems associated with the optimization of treatment in patients with breast cancer (BC) who have undergone organ-preserving operations. The occurrence of BC recurrences after organ-preserving treatment, their determination and prognostic factors are a challenge

Rationale for repeat breast-conserving surgery after in-breast recurrence of breast cancer

The main outcomes of our interest were local control and survival of 76 patients with local recurrence of breast cancer treated with conservative surgery (n = 32) or mastectomy (n = 44). There was not statistically significant difference in the probability of 5-years overall (81 %, 64.2 %; p = 0,245) and metastatic-free survival (60.7 %, 57.1 %, p = 0,553), as measured from the recurrence, and in rates of subsequent in-breast (12.5 %) or chest wall (11.4 %) recurrences between women of these two groups respectively. This fact is rationale for repeat breast-conserv- ing surgery in appropriately selected patients and requires further investigations