Residue gamma 153Cys is essential for the formation of the complexes A alpha gamma and B beta gamma, assembly intermediates for the A alpha B beta gamma complex and intact fibrinogen

ArticleCLINICA CHIMICA ACTA. 353(1-2): 157-164 (2005)journal articl

Citrullinated fibrinogen shows defects in FPA and FPB release and fibrin polymerization catalyzed by thrombin

ArticleClinica Chimica Acta. 401(1-2):119-123 (2009)journal articl

Geometrical Effects of Baryon Density Inhomogeneities on Primordial Nucleosynthesis

We discuss effects of fluctuation geometry on primordial nucleosynthesis. For the first time we consider condensed cylinder and cylindrical-shell fluctuation geometries in addition to condensed spheres and spherical shells. We find that a cylindrical shell geometry allows for an appreciably higher baryonic contribution to be the closure density (\Omega_b h_{50}^2 \la 0.2) than that allowed in spherical inhomogeneous or standard homogeneous big bang models. This result, which is contrary to some other recent studies, is due to both geometry and recently revised estimates of the uncertainties in the observationally inferred primordial light-element abundances. We also find that inhomogeneous primordial nucleosynthesis in the cylindrical shell geometry can lead to significant Be and B production. In particular, a primordial beryllium abundance as high as [Be] = 12 + log(Be/H) $\approx -3$ is possible while still satisfying all of the light-element abundance constraints.Comment: Latex, 20 pages + 11 figures(not included). Entire ps file with embedded figures available via anonymous ftp at ftp://genova.mtk.nao.ac.jp/pub/prepri/bbgeomet.ps.g

In vitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gamma Asn319, Asp320 deletion dysfibrinogen, Otsu I

ArticleTHROMBOSIS RESEARCH. 118(5): 651-661 (2006)journal articl

Substitution of the gamma-chain Asn308 disturbs the D : D interface affecting fibrin polymerization, fibrinopeptide B release, and FXIIIa-catalyzed cross-linking

This research was originally published in Blood. Authors. Okumura, N; Gorkun, OV; Terasawa, F; Lord, ST Title. Blood. 2004; 103(12): 4157-4163. © by the American Society of Hematology.ArticleBLOOD. 103(11): 4157-4163 (2004)journal articl

Big Bang Nucleosynthesis and Lepton Number Asymmetry in the Universe

Recently it is reported that there is the discrepancy between big bang nucleosynthesis theory and observations (BBN crisis). We show that BBN predictions agree with the primordial abundances of light elements, He4, D, He3 and Li7 inferred from the observational data if an electron neutrino has a net chemical potential xi_{nu_e} due to lepton asymmetry. We estimate that xi_{nu_e} = 0.043^{+0.040}_{-0.040} (95% C.L.) and Omega_bh^2 = 0.015^{+0.006}_{-0.003} (95% C.L.).Comment: 10 pages, using AAS LATEX and three postscript figure

Administration of isoferulic acid improved the survival rate of lethal influenza virus pneumonia in mice.

BACKGROUND: Isoferulic acid (IFA) is a main active ingredient of the rhizoma of Cimicifuga beracleifolia, which is used frequently in Japanese traditional medicine as an anti-inflammatory drug. It has been revealed that IFA inhibits the production of macrophage inflammatory protein-2 (MIP-2), which is a murine counterpart of the chemokine family that may contribute to the pathogenesis of inflammatory diseases through the chemotactic activity for inflammatory and immune effector cells. AIM OF THE STUDY: In this study, we investigated the therapeutic effect of IFA on the progression of lethal influenza virus pneumonia in mice by comparison with that of dexamethasone (DX), a potent inhibitor for various inflammatory cytokines including MIP-2. METHODS: Mice were infected by intranasal inoculation of influenza virus under ether anesthesia. The IFA or DX was given by oral administration once daily for 4 days after infection. After infection, the survival rate and the change in body weight were daily monitored. RESULTS: IFA administration markedly improved the survival rate and body weight loss of influenza virus-infected mice in a suitable dose range (0.5 mg/day). However, DX administration did not show a beneficial effect at any dose. CONCLUSION: These data suggested that IFA is a novel tool not only for the intervention therapy, but also for the studies on the pathogenesis of influenza virus-induced pneumonia