262 research outputs found
Fluctuating geometries, q-observables, and infrared growth in inflationary spacetimes
Infrared growth of geometrical fluctuations in inflationary spacetimes is
investigated. The problem of gauge-invariant characterization of growth of
perturbations, which is of interest also in other spacetimes such as black
holes, is addressed by studying evolution of the lengths of curves in the
geometry. These may either connect freely falling "satellites," or wrap
non-trivial cycles of geometries like the torus, and are also used in
diffeomorphism- invariant constructions of two-point functions of field
operators. For spacelike separations significantly exceeding the Hubble scale,
no spacetime geodesic connects two events, but one may find geodesics
constrained to lie within constant-time spatial slices. In inflationary
geometries, metric perturbations produce significant and growing corrections to
the lengths of such geodesics, as we show in both quantization on an inflating
torus and in standard slow-roll inflation. These become large, signaling
breakdown of a perturbative description of the geometry via such observables,
and consistent with perturbative instability of de Sitter space. In particular,
we show that the geodesic distance on constant time slices during inflation
becomes non-perturbative a few e-folds after a given scale has left the
horizon, by distances \sim 1/H^3 \sim RS, obstructing use of such geodesics in
constructing IR-safe observables based on the spatial geometry. We briefly
discuss other possible measures of such geometrical fluctuations.Comment: 33 pages, 2 figures, latex; v2: typos corrected, references improve
de Sitter limit of inflation and nonlinear perturbation theory
We study the fourth order action of the comoving curvature perturbation in an
inflationary universe in order to understand more systematically the de Sitter
limit in nonlinear cosmological perturbation theory. We derive the action of
the curvature perturbation to fourth order in the comoving gauge, and show that
it vanishes sufficiently fast in the de Sitter limit. By studying the de Sitter
limit, we then extrapolate to the n'th order action of the comoving curvature
perturbation and discuss the slow-roll order of the n-point correlation
function.Comment: 14 pages, 1 figure; typos corrected and discussion of tensor modes
adde
A new diagrammatic representation for correlation functions in the in-in formalism
In this paper we provide an alternative method to compute correlation
functions in the in-in formalism, with a modified set of Feynman rules to
compute loop corrections. The diagrammatic expansion is based on an iterative
solution of the equation of motion for the quantum operators with only retarded
propagators, which makes each diagram intrinsically local (whereas in the
standard case locality is the result of several cancellations) and endowed with
a straightforward physical interpretation. While the final result is strictly
equivalent, as a bonus the formulation presented here also contains less graphs
than other diagrammatic approaches to in-in correlation functions. Our method
is particularly suitable for applications to cosmology.Comment: 14 pages, matches the published version. includes a modified version
of axodraw.sty that works with the Revtex4 clas
Lead Sources in Human Diet in Greenland
Although blood lead levels have declined in Greenland, they are still elevated despite the fact that lead levels in the Greenland environment are very low. Fragments of lead shot in game birds have been suggested as an important source of dietary exposure, and meals of sea birds, particularly eider, contain high concentrations of lead. In a cross-sectional population survey in Greenland in 1993â1994, blood lead adjusted for age and sex was found to be associated with the reported consumption of sea birds. Participants reporting less than weekly intake of sea birds had blood lead concentrations of approximately 75 ÎŒg/L, whereas those who reported eating sea birds several times a week had concentrations of approximately 110 ÎŒg/L, and those who reported daily intake had concentrations of 170 ÎŒg/L (p = 0.01). Blood lead was not associated with dietary exposure to other local or imported food items
On the divergences of inflationary superhorizon perturbations
We discuss the infrared divergences that appear to plague cosmological
perturbation theory. We show that within the stochastic framework they are
regulated by eternal inflation so that the theory predicts finite fluctuations.
Using the formalism to one loop, we demonstrate that the infrared
modes can be absorbed into additive constants and the coefficients of the
diagrammatic expansion for the connected parts of two and three-point functions
of the curvature perturbation. As a result, the use of any infrared cutoff
below the scale of eternal inflation is permitted, provided that the background
fields are appropriately redefined. The natural choice for the infrared cutoff
would of course be the present horizon; other choices manifest themselves in
the running of the correlators. We also demonstrate that it is possible to
define observables that are renormalization group invariant. As an example, we
derive a non-perturbative, infrared finite and renormalization point
independent relation between the two-point correlators of the curvature
perturbation for the case of the free single field.Comment: 12 page
The Kramers-Moyal Equation of the Cosmological Comoving Curvature Perturbation
Fluctuations of the comoving curvature perturbation with wavelengths larger
than the horizon length are governed by a Langevin equation whose stochastic
noise arise from the quantum fluctuations that are assumed to become classical
at horizon crossing. The infrared part of the curvature perturbation performs a
random walk under the action of the stochastic noise and, at the same time, it
suffers a classical force caused by its self-interaction. By a path-interal
approach and, alternatively, by the standard procedure in random walk analysis
of adiabatic elimination of fast variables, we derive the corresponding
Kramers-Moyal equation which describes how the probability distribution of the
comoving curvature perturbation at a given spatial point evolves in time and is
a generalization of the Fokker-Planck equation. This approach offers an
alternative way to study the late time behaviour of the correlators of the
curvature perturbation from infrared effects.Comment: 27 page
Consultation on UTUC, Stockholm 2018 aspects of risk stratification: long-term results and follow-up
Purpose:
To summarize current knowledge on upper urinary tract carcinoma (UTUC) regarding risk stratification, long-term results, and follow-up.
Methods:
A scoping review approach was applied to search literature in Pubmed, Web of Science, and Embase. Consensus was reached through discussions at Consultation on UTUC, September 2018, Stockholm.
Results:
To optimize oncological outcome considering both cancer-specific survival (CSS) and overall survival (OS), it is essential to identify pre- and postoperative prognostic factors. In low-risk UTUC, kidney-sparing surgery (KSS) and radical nephroureterectomy (RNU) offer equivalent CSS, whereas RNU may result in poorer OS due to nephron loss. For more aggressive tumours, undergrading can lead to insufficient treatment. The strongest prognostic factors are tumour stage and grade. Determining grade is best achieved by ureterorenoscopy (URS) with focal samples, biopsy and cytology. Staging is more difficult but can be indirectly achieved by multiphase computed tomography urography (CTU) or tumour grade determined by cytology and histopathology. Patients treated with KSS should be monitored closely with regular follow-ups (URS and CTU).
Conclusion:
KSS should be offered in low-risk UTUC when feasible, whereas RNU is the treatment of choice in organ-confined high-risk UTUC. Intravesical recurrence (IVR) is common after RNU, but a single postoperative dose of mitomycin instillation decreases IVR. Endourological management has high local and bladder recurrence rates; however, its effect on CSS or overall survival OS is unclear. RNU is associated with significant risk of chronic kidney disease. Careful selection of patients and risk stratification are mandatory, and patients should be followed according to strict protocols
Semiclassical relations and IR effects in de Sitter and slow-roll space-times
We calculate IR divergent graviton one-loop corrections to scalar correlators
in de Sitter space, and show that the leading IR contribution may be reproduced
via simple semiclassical consistency relations. One can likewise use such
semiclassical relations to calculate leading IR corrections to correlators in
slow-roll inflation. The regulated corrections shift the tensor/scalar ratio
and consistency relation of single field inflation, and non-gaussianity
parameters averaged over very large distances. For inflation of sufficient
duration, for example arising from a chaotic inflationary scenario, these
corrections become of order unity. First-order corrections of this size
indicate a breakdown of the perturbative expansion, and suggest the need for a
non-perturbative description of the corresponding regime. This is analogous to
a situation argued to arise in black hole evolution, and to interfere with a
sharp perturbative calculation of "missing information" in Hawking radiation.Comment: 32 pages, 2 figures; v2: running of spectral index included and other
minor changes; v3: minor changes to agree with published versio
Nonlocality vs. complementarity: a conservative approach to the information problem
A proposal for resolution of the information paradox is that "nice slice"
states, which have been viewed as providing a sharp argument for information
loss, do not in fact do so as they do not give a fully accurate description of
the quantum state of a black hole. This however leaves an information
*problem*, which is to provide a consistent description of how information
escapes when a black hole evaporates. While a rather extreme form of
nonlocality has been advocated in the form of complementarity, this paper
argues that is not necessary, and more modest nonlocality could solve the
information problem. One possible distinguishing characteristic of scenarios is
the information retention time. The question of whether such nonlocality
implies acausality, and particularly inconsistency, is briefly addressed. The
need for such nonlocality, and its apparent tension with our empirical
observations of local quantum field theory, may be a critical missing piece in
understanding the principles of quantum gravity.Comment: 11 pages of text and figures, + references. v2 minor text. v3 small
revisions to match final journal versio
Enhancing the tensor-to-scalar ratio in simple inflation
We show that in theories with a nontrivial kinetic term the contribution of
the gravitational waves to the CMB fluctuations can be substantially larger
than that is naively expected in simple inflationary models. This increase of
the tensor-to-scalar perturbation ratio leads to a larger B-component of the
CMB polarization, thus making the prospects for future detection much more
promising. The other important consequence of the considered model is a higher
energy scale of inflation and hence higher reheating temperature compared to a
simple inflation.Comment: 9 pages, 1 figure and references are added, discussion is slightly
extended, published versio
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