Blinding for precision scattering experiments: The MUSE approach as a case study

Human bias is capable of changing the analysis of measured data sufficiently to alter the results of an experiment. It is incumbent upon modern experiments, especially those investigating quantities considered contentious in the broader community, to blind their analysis in an effort to minimize bias. The choice of a blinding model is experiment specific, but should also aim to prevent accidental release of results before an analysis is finalized. In this paper, we discuss common threats to an unbiased analysis, as well as common quantities that can be blinded in different types of nuclear physics experiments. We use the Muon Scattering Experiment as an example, and detail the blinding scheme used therein.Comment: 6 pages, 3 figure

Daedalea gibbosa substances inhibit LPS-induced expression of iNOS by suppression of NF-kappaB and MAPK activities in RAW 264.7 macrophage cells.

Nitric oxide (NO) is a radical molecule produced by iNOS and plays a role in various physiological and pathophysiological conditions including inflammatory diseases and cancer. In the present study, organic extract of Daedalea gibbosa was effective in inhibiting NO and PGE2 production in RAW 264.7 cells. The extract of D. gibbosa was chemically fractionated leading to the isolation of three active fractions (F5-F7) that were effective in inhibiting NO and iNOS production. In addition, F6 and F7 significantly inhibited the iNOS transcript, while F5 did not cause a reduction in the iNOS transcript. Furthermore, the active fractions showed a differential effect on levels of phospho-p38, phospho-JNK, and phospho-IKBalpha. Phopsho-p38 was moderately inhibited by F5 and only F7 was significantly active in inhibiting phospho-IKBalpha. Interestingly, all active fractions significantly enhanced levels of phospho-JNK. In addition, the three active fractions also showed differential inhibitory effects on NF-kappaB DNA binding activity

Instrumental uncertainties in radiative corrections for the MUSE experiment

The MUSE experiment at the Paul Scherrer Institute is measuring elastic lepton-proton scattering cross sections in a four-momentum transfer range from $Q^2$ of approximately 0.002 to 0.08 GeV$^2$ using positively and negatively charged electrons and muons. The extraction of the Born cross sections from the experimental data requires radiative corrections. Estimates of the instrumental uncertainties in those corrections have been made using the ESEPP event generator. The results depend in particular on the minimum lepton momentum that contributes to the experimental cross section and the fraction of events with hard initial-state radiation that is detected in the MUSE calorimeter and is excluded from the data. These results show that the angular-dependent instrumental uncertainties in radiative corrections to the electron cross section are better than 0.4 % and are negligible for the muon cross section.Comment: Article to be submitted to the EPJ A Topical Collection on radiative corrections. 9 pages, 5 figures, 2 table

Observation of large scale precursor correlations between cosmic rays and earthquakes with a periodicity similar to the solar cycle

The search for correlations between secondary cosmic ray detection rates and seismic effects has long been a subject of investigation motivated by the hope of identifying a new precursor type that could feed a global early warning system against earthquakes. Here we show for the first time that the average variation of the cosmic ray detection rates correlates with the global seismic activity to be observed with a time lag of approximately two weeks, and that the significance of the effect varies with a periodicity resembling the undecenal solar cycle, with a shift in phase of around three years, exceeding 6 σ at local maxima. The precursor characteristics of the observed correlations point to a pioneer perspective of an early warning system against earthquakes

The present and future of QCD

International audienceThis White Paper presents an overview of the current status and future perspective of QCD research, based on the community inputs and scientific conclusions from the 2022 Hot and Cold QCD Town Meeting. We present the progress made in the last decade toward a deep understanding of both the fundamental structure of the sub-atomic matter of nucleon and nucleus in cold QCD, and the hot QCD matter in heavy ion collisions. We identify key questions of QCD research and plausible paths to obtaining answers to those questions in the near future, hence defining priorities of our research over the coming decades

The Present and Future of QCD

International audienceThis White Paper presents the community inputs and scientific conclusions from the Hot and Cold QCD Town Meeting that took place September 23-25, 2022 at MIT, as part of the Nuclear Science Advisory Committee (NSAC) 2023 Long Range Planning process. A total of 424 physicists registered for the meeting. The meeting highlighted progress in Quantum Chromodynamics (QCD) nuclear physics since the 2015 LRP (LRP15) and identified key questions and plausible paths to obtaining answers to those questions, defining priorities for our research over the coming decade. In defining the priority of outstanding physics opportunities for the future, both prospects for the short (~ 5 years) and longer term (5-10 years and beyond) are identified together with the facilities, personnel and other resources needed to maximize the discovery potential and maintain United States leadership in QCD physics worldwide. This White Paper is organized as follows: In the Executive Summary, we detail the Recommendations and Initiatives that were presented and discussed at the Town Meeting, and their supporting rationales. Section 2 highlights major progress and accomplishments of the past seven years. It is followed, in Section 3, by an overview of the physics opportunities for the immediate future, and in relation with the next QCD frontier: the EIC. Section 4 provides an overview of the physics motivations and goals associated with the EIC. Section 5 is devoted to the workforce development and support of diversity, equity and inclusion. This is followed by a dedicated section on computing in Section 6. Section 7 describes the national need for nuclear data science and the relevance to QCD research

The Present and Future of QCD

This White Paper presents the community inputs and scientific conclusions from the Hot and Cold QCD Town Meeting that took place September 23-25, 2022 at MIT, as part of the Nuclear Science Advisory Committee (NSAC) 2023 Long Range Planning process. A total of 424 physicists registered for the meeting. The meeting highlighted progress in Quantum Chromodynamics (QCD) nuclear physics since the 2015 LRP (LRP15) and identified key questions and plausible paths to obtaining answers to those questions, defining priorities for our research over the coming decade. In defining the priority of outstanding physics opportunities for the future, both prospects for the short (~ 5 years) and longer term (5-10 years and beyond) are identified together with the facilities, personnel and other resources needed to maximize the discovery potential and maintain United States leadership in QCD physics worldwide. This White Paper is organized as follows: In the Executive Summary, we detail the Recommendations and Initiatives that were presented and discussed at the Town Meeting, and their supporting rationales. Section 2 highlights major progress and accomplishments of the past seven years. It is followed, in Section 3, by an overview of the physics opportunities for the immediate future, and in relation with the next QCD frontier: the EIC. Section 4 provides an overview of the physics motivations and goals associated with the EIC. Section 5 is devoted to the workforce development and support of diversity, equity and inclusion. This is followed by a dedicated section on computing in Section 6. Section 7 describes the national need for nuclear data science and the relevance to QCD research