8 research outputs found
Stereoselective epoxidation of bicyclic monoterpenes with tert-amyl hydroperoxide in presence of molybdenum compounds
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Synthesis of the macrocyclic core of (-)-pladienolide B
No full textAn efficient synthesis of the macrocyclic core of (-)-pladienolide B is disclosed. The concise route relies on a chiral auxiliary-mediated asymmetric aldol addition and an osmium-catalyzed asymmetric dihydroxylation to install the three oxygenated stereocenters of the macrocycle. This purely reagent-controlled and flexible strategy sets the stage for future analogue syntheses and structure-activity relationship plotting of the appealing anticancer lead structure pladienolide B
Synthesis and Catalytic Epoxidation Activity with TBHP and H2O2 of Dioxo-, Oxoperoxo-, and Oxodiperoxo Molybdenum(VI) and Tungsten(VI) Compounds Containing Monodentate or Bidentate Phosphine Oxide Ligands: Crystal Structures of W(O)2(Cl)2(OPMePh2)2, W(O)(O)2(Cl)2(OPMePh2)2, Mo(O)2(Cl)2dppmO2C4H10O, W(O)2(Cl)2dppmO2, Mo(O)(O2)2dppmO2, and W(O)(O2)2dppmO2
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