Explosive Nitrotriazolone Formulates

Nitrotriazolone has been synthesised and fully characterised. This explosive was found to exhibit self-binding properties forming pellets at different loads. The compression strength of these pellets were in the range 80-128 kgf/cm2 under one to three tonne/cm2 load. Other pressable formulations containing nitrotriazolone have also been successfully prepared. A composition comparable to composition B was also prepared using nitrotriazolone and trinitrotoluene (60:40). Mechanical properties and insensitivity of this new composition were found to be superior

Necrosis related HIF-1α expression predicts prognosis in patients with endometrioid endometrial carcinoma

<p>Abstract</p> <p>Background</p> <p>Hypoxia inducible factor 1α (HIF-1α) plays an essential role in the adaptive response of cells to hypoxia and is associated with aggressive tumour behaviour. We have shown p27^kip1, which is generally reduced in endometrial cancer, to be re-expressed in hypoxic regions. This possibly contributes to survival of cancer cells. The aim of this study was to evaluate the prognostic value of HIF-1α and p27^kipexpression in patients with endometrioid endometrial cancer.</p> <p>Methods</p> <p>Expression levels of HIF-1α, CAIX, Glut-1, and p27^kip1were analyzed by immunohistochemistry. Percentage of positive cells, staining pattern (perinecrotic, diffuse, or mixed) and presence of necrosis were noted.</p> <p>Results</p> <p>Necrosis was correlated with shortened disease free survival (DFS) (p <it>= </it>0.008) and overall survival (OS) (p <it>= </it>0.045). For DFS, perinecrotic HIF-1α expression was also prognostic (p <it>= </it>0.044). Moreover, high p27^kip1expression was an additional prognostic factor for these patients with perinecrotic HIF-1α expression. In multivariate Cox regression, perinecrotic HIF-expression emerged as an independent prognostic factor. Perinecrotic HIF-1α expression was significantly associated with CAIX and Glut-1 expression, pointing towards functional HIF-1.</p> <p>Conclusions</p> <p>In patients with endometrioid endometrial cancer, necrosis and necrosis-related expression of HIF-1α are important prognostic factors. More aggressive adjuvant treatment might be necessary to improve the outcome of patients with these characteristics.</p

Nanotechnology advances towards development of targeted-treatment for obesity

Obesity through its association with type 2 diabetes (T2D), cancer and cardiovascular diseases (CVDs), poses a serious health threat, as these diseases contribute to high mortality rates. Pharmacotherapy alone or in combination with either lifestyle modifcation or surgery, is reliable in maintaining a healthy body weight, and preventing progression to obesity-induced diseases. However, the anti-obesity drugs are limited by non-specifcity and unsustainable weight loss efects. As such, novel and improved approaches for treatment of obesity are urgently needed. Nanotechnology-based therapies are investigated as an alternative strategy that can treat obesity and be able to overcome the drawbacks associated with conventional therapies. The review presents three nanotechnology-based anti-obesity strategies that target the white adipose tissues (WATs) and its vasculature for the reversal of obesity. These include inhibition of angiogenesis in the WATs, transformation of WATs to brown adipose tissues (BATs), and photothermal lipolysis of WATs. Compared to conventional therapy, the targeted-nanosystems have high tolerability, reduced side efects, and enhanced efcacy. These efects are reproducible using various nanocarriers (liposomes, polymeric and gold nanoparticles), thus providing a proof of concept that targeted nanotherapy can be a feasible strategy that can combat obesity and prevent its comorbiditie

Synthesis and Antimicrobial Activity of new (Z)-2-((5-(4- Hydroxybenzylidene)-4-Oxo-4,5-Dihydrothiazol-2-Yl)Amino) Acid and its Derivatives

ABSTRACT A series of (Z)-2-((5-(4-hydroxybenzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)amino) acid and its derivatives were synthesized from appropriate 2-thioxothiazolidin-4-one using nucleophilic substitution and Knoevenagel condensation. All compounds have been synthesized, characterized and screened for their antimicrobial activity against gram positive bacteria and gram negative bacteria along with Ampicillin and Ciprofloxacin as standard drug. According to results obtained all compound shows good to moderate activity against all strain tested, compatible to Ampicillin but lower than Ciprofloxacin. Amongst these compounds (6c) shows very good and moderate activity as compare to standards drugs against Gram positive bacteria B. subtilus and S. aureus. Some of the most potent compounds, namely (6b, 6h and 6j) possessed selectively antimicrobial activity

A facile synthesis of novel series (Z)-2-((4-oxo-5-(thiophen-2-ylmethylene)-4,5-dihydrothiazol-2-yl)amino) substituted acid

A new effective approach to the synthesis of some novel series of (Z)-2-((4-oxo-5-(thiophen-2-ylmethylene)-4,5-dihydrothiazol-2-yl)amino) substituted acid is reported at room temperature, less reaction time with good to excellent yields

Two days National Conference -VISHWATECH 2014 A Review-FPGA Implementation of Different Steganographic Technique

Abstract: Steganography is a method of hiding the information in a cover in such a way that only intended recipient can know that there is a hidden message. In Steganography for hiding informat ion any embedding mediu m can be used, called as carriers. These carriers can be images, audio files, video files, and text files. In this paper we have focused on steganographic techniques for image files. Image steganography techniques now days developed with an alternative approach based on an embedded FPGA system for image processing. Due to its reconfigurable ability Various FPGA approaches are chosen and without requiring hardware change-out, the uses of FPGA type Dev ices expand the product life by updating data stream files

Efficient Location Finding with Text Based Keyword Searching System

ABSTRACT: Many search modules area unit won&apos;t to search something from anywhere; this method is employed to quick nearest neighbour search exploitation keyword. Existing work usually specialise in finding top-k Nearest Neighbours.It doesn&apos;t take into account the density of knowledge objects within the spatial area. Conjointly these strategies area unit low efficient for progressive question. however in meant system, for instance once there&apos;s seek for nearest eating place, rather than considering all the hotels, a nearest neighbour question would elicit the eating place that&apos;s, nearest among those whose menus contain spicy, hard liquor all at constant time, resolution to such queries is predicated on the IR2-tree, however IR2-tree having some drawbacks. IR2-tree contains Signature file due to its conservative nature may lead to some search result that only contains single keyword result Efficiency of IR2-tree badly is wedged attributable to some drawbacks in it. Thespatial inverted index is that the technique which is able to be the answer for this drawback