211 research outputs found
Discontinuation of infliximab after attaining low disease activity in patients with rheumatoid arthritis: RRR (remission induction by Remicade in RA) study
Generalized Toda Theory from Six Dimensions and the Conifold
Recently, a physical derivation of the Alday-Gaiotto-Tachikawa correspondence
has been put forward. A crucial role is played by the complex Chern-Simons
theory arising in the 3d-3d correspondence, whose boundary modes lead to Toda
theory on a Riemann surface. We explore several features of this derivation and
subsequently argue that it can be extended to a generalization of the AGT
correspondence. The latter involves codimension two defects in six dimensions
that wrap the Riemann surface. We use a purely geometrical description of these
defects and find that the generalized AGT setup can be modeled in a pole region
using generalized conifolds. Furthermore, we argue that the ordinary conifold
clarifies several features of the derivation of the original AGT
correspondence.Comment: 27+2 pages, 3 figure
Confirmation of Multiple Risk Loci and Genetic Impacts by a Genome-Wide Association Study of Type 2 Diabetes in the Japanese Population
Localization of N=4 Superconformal Field Theory on S^1 x S^3 and Index
We provide the geometrical meaning of the superconformal index.
With this interpretation, the superconformal index can be realized
as the partition function on a Scherk-Schwarz deformed background. We apply the
localization method in TQFT to compute the deformed partition function since
the deformed action can be written as a -exact form. The
critical points of the deformed action turn out to be the space of flat
connections which are, in fact, zero modes of the gauge field. The one-loop
evaluation over the space of flat connections reduces to the matrix integral by
which the superconformal index is expressed.Comment: 42+1 pages, 2 figures, JHEP style: v1.2.3 minor corrections, v4 major
revision, conclusions essentially unchanged, v5 published versio
Cartan subalgebras and the UCT problem, II
We show that outer approximately represenbtable actions of a finite cyclic
group on UCT Kirchberg algebras satisfy a certain quasi-freeness type property
if the corresponding crossed products satisfy the UCT and absorb a suitable UHF
algebra tensorially. More concretely, we prove that for such an action there
exists an inverse semigroup of homogeneous partial isometries that generates
the ambient C*-algebra and whose idempotent semilattice generates a Cartan
subalgebra. We prove a similar result for actions of finite cyclic groups with
the Rokhlin property on UCT Kirchberg algebras absorbing a suitable UHF
algebra. These results rely on a new construction of Cartan subalgebras in
certain inductive limits of Cartan pairs. We also provide a characterisation of
the UCT problem in terms of finite order automorphisms, Cartan subalgebras and
inverse semigroups of partial isometries of the Cuntz algebra .
This generalizes earlier work of the authors.Comment: minor revisions; final version, accepted for publication in Math.
Ann.; 26 page
Brane cosmological solutions in six-dimensional warped flux compactifications
We study cosmology on a conical brane in the six-dimensional
Einstein-Maxwell-dilaton system, where the extra dimensions are compactified by
a magnetic flux. We systematically construct exact cosmological solutions using
the fact that the system is equivalently described by (6+n)-dimensional pure
Einstein-Maxwell theory via dimensional reduction. In particular, we find a
power-law inflationary solution for a general dilatonic coupling. When the
dilatonic coupling is given by that of Nishino-Sezgin chiral supergravity, this
reduces to the known solution which is not inflating. The power-law solution is
shown to be the late-time attractor. We also investigate cosmological tensor
perturbations in this model using the (6+n)-dimensional description. We obtain
the separable equation of motion and find that there always exist a zero mode,
while tachyonic modes are absent in the spectrum. The mass spectrum of
Kaluza-Klein modes is obtained numerically.Comment: 12 pages, 2 figures; v2: references added; v3: version published in
JCA
Super-A-polynomials for Twist Knots
We conjecture formulae of the colored superpolynomials for a class of twist
knots where p denotes the number of full twists. The validity of the
formulae is checked by applying differentials and taking special limits. Using
the formulae, we compute both the classical and quantum super-A-polynomial for
the twist knots with small values of p. The results support the categorified
versions of the generalized volume conjecture and the quantum volume
conjecture. Furthermore, we obtain the evidence that the Q-deformed
A-polynomials can be identified with the augmentation polynomials of knot
contact homology in the case of the twist knots.Comment: 22+16 pages, 16 tables and 5 figures; with a Maple program by Xinyu
Sun and a Mathematica notebook in the ancillary files linked on the right; v2
change in appendix B, typos corrected and references added; v3 change in
section 3.3; v4 corrections in Ooguri-Vafa polynomials and quantum
super-A-polynomials for 7_2 and 8_1 are adde
EFFECTS OF LOW-DOSE-GAMMA RAYS ON THE IMMUNE SYSTEM OF DIFFERENT ANIMAL MODELS OF DISEASE
We reviewed the beneficial or harmful effects of low-dose ionizing radiation on several diseases based on a search of the literature. The attenuation of autoimmune manifestations in animal disease models irradiated with low-dose γ-rays was previously reported by several research groups, whereas the exacerbation of allergic manifestations was described by others. Based on a detailed examination of the literature, we divided animal disease models into two groups: one group consisting of collagen-induced arthritis (CIA), experimental encephalomyelitis (EAE), and systemic lupus erythematosus, the pathologies of which were attenuated by low-dose irradiation, and another group consisting of atopic dermatitis, asthma, and Hashimoto’s thyroiditis, the pathologies of which were exacerbated by low-dose irradiation. The same biological indicators, such as cytokine levels and Tcell subpopulations, were examined in these studies. Low-dose irradiation reduced interferon (IFN)-gamma (γ) and interleukin (IL)-6 levels and increased IL-5 levels and the percentage of CD4+CD25+Foxp3+Treg cells in almost all immunological disease cases examined. Variations in these biological indicators were attributed to the attenuation or exacerbation of the disease’s manifestation. We concluded that autoimmune diseases caused by autoantibodies were attenuated by low-dose irradiation, whereas diseases caused by antibodies against external antigens, such as atopic dermatitis, were exacerbated
Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress
In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this clinical scenario has been studied using a rat model of stress-induced reinstatement of drug seeking. Here, we first discuss the generality of stress-induced reinstatement to different drugs of abuse, different stressors, and different behavioral procedures. We also discuss neuropharmacological mechanisms, and brain areas and circuits controlling stress-induced reinstatement of drug seeking. We conclude by discussing results from translational human laboratory studies and clinical trials that were inspired by results from rat studies on stress-induced reinstatement. Our main conclusions are (1) The phenomenon of stress-induced reinstatement, first shown with an intermittent footshock stressor in rats trained to self-administer heroin, generalizes to other abused drugs, including cocaine, methamphetamine, nicotine, and alcohol, and is also observed in the conditioned place preference model in rats and mice. This phenomenon, however, is stressor specific and not all stressors induce reinstatement of drug seeking. (2) Neuropharmacological studies indicate the involvement of corticotropin-releasing factor (CRF), noradrenaline, dopamine, glutamate, kappa/dynorphin, and several other peptide and neurotransmitter systems in stress-induced reinstatement. Neuropharmacology and circuitry studies indicate the involvement of CRF and noradrenaline transmission in bed nucleus of stria terminalis and central amygdala, and dopamine, CRF, kappa/dynorphin, and glutamate transmission in other components of the mesocorticolimbic dopamine system (ventral tegmental area, medial prefrontal cortex, orbitofrontal cortex, and nucleus accumbens). (3) Translational human laboratory studies and a recent clinical trial study show the efficacy of alpha-2 adrenoceptor agonists in decreasing stress-induced drug craving and stress-induced initial heroin lapse
- …