Arterial hypertension in patients with non-specific aortoarteritis

Non-specific aortoarteritis (Takayasu arteritis) is a rare disease, it is a chronic vasculitis that occurs with the defeat of the aorta and main arteries, the development of stenosis of the arteries and ischemia of the relevant organs. In most cases, symptomatic arterial hypertension develops. The article presents a modern view of the peculiarities of the course of arterial hypertension, considered methods of diagnosis and treatment of this disease

Laboratory study of electromagnetic initiation of slip

Recently Russian seismologists reported the triggering effect of MHD soundings on microseismic activity in the Central Asia test area.The paper focuses on an experimental test of the possibility of triggering the mechanical instability of a system that is close to critical state by a series of electromagnetic pulses.The mechanical system consisted of two pieces of rock;the upper piece can slip on the fixed supporting sample if the latter one is tilted up to the critical angle.In this state,the triggering of mechanical instability by some weak impact such as electrical pulse became more probable.The slope of support in the experiment is an analogue of tectonic stress in natural conditions.The preliminary experiments,carried out in a dry environment,at the humidity of atmosphere 30-50%,show that a strong EM-pulse induces sliding of a sample of rock (granite,basalt,labradorite)placed on the supporting sample which is inclined at the slope close to,but less than,the critical angle with a probability 0.07

Impact of the COVID-19 pandemic on total, sex- and age-specific all-cause mortality in 20 countries worldwide during 2020: results from the C-MOR project

Background To understand the impact of the COVID-19 pandemic on mortality, this study investigates overall, sex- and age-specific excess all-cause mortality in 20 countries, during 2020. Methods Total, sex- and age-specific weekly all-cause mortality for 2015–2020 was collected from national vital statistics databases. Excess mortality for 2020 was calculated by comparing weekly 2020 observed mortality against expected mortality, estimated from historical data (2015–2019) accounting for seasonality, long- and short-term trends. Crude and age-standardized rates were analysed for total and sex-specific mortality. Results Austria, Brazil, Cyprus, England and Wales, France, Georgia, Israel, Italy, Northern Ireland, Peru, Scotland, Slovenia, Sweden, and the USA displayed substantial excess age-standardized mortality of varying duration during 2020, while Australia, Denmark, Estonia, Mauritius, Norway, and Ukraine did not. In sex-specific analyses, excess mortality was higher in males than females, except for Slovenia (higher in females) and Cyprus (similar in both sexes). Lastly, for most countries substantial excess mortality was only detectable (Austria, Cyprus, Israel, and Slovenia) or was higher (Brazil, England and Wales, France, Georgia, Italy, Northern Ireland, Sweden, Peru and the USA) in the oldest age group investigated. Peru demonstrated substantial excess mortality even in the <45 age group. Conclusions This study highlights that excess all-cause mortality during 2020 is context dependent, with specific countries, sex- and age-groups being most affected. As the pandemic continues, tracking excess mortality is important to accurately estimate the true toll of COVID-19, while at the same time investigating the effects of changing contexts, different variants, testing, quarantine, and vaccination strategies

Combination of verapamil and trandolapril: therapeutic potential for high-risk patients with arterial hypertension

The review is devoted to the perspectives of combined therapy with verapamil SR and trandolapril in high-risk patients with arterial hypertension (AH). The results of international clinical trials confirm effectiveness of verapamil SR and trandolapril (Tarka medication) in AH combined with coronary heart disease, diabetes mellitus, chronic diabetic and non-diabetic kidney diseases

Strong Wind on the Territory of Georgia in 2014-2018

2014-2018 data on strong wind cases (V≥15 m/s) are considered. The climatic characteristics of strong winds, such as the number of days, wind speed, and direction, are studied for a five-year study period. Also, strong wind distribution areas are defined according to the municipalities. Some cases of damage caused by strong winds in 2014-2018 are described. Based on the available data a geoinformation map of the distribution of strong winds in the regions of Georgia are compiled

Laboratory study of electromagnetic initiation of slip

Recently Russian seismologists reported the triggering effect of MHD soundings on microseismic activity in the Central Asia test area.The paper focuses on an experimental test of the possibility of triggering the mechanical instability of a system that is close to critical state by a series of electromagnetic pulses.The mechanical system consisted of two pieces of rock;the upper piece can slip on the fixed supporting sample if the latter one is tilted up to the critical angle.In this state,the triggering of mechanical instability by some weak impact such as electrical pulse became more probable.The slope of support in the experiment is an analogue of tectonic stress in natural conditions.The preliminary experiments,carried out in a dry environment,at the humidity of atmosphere 30-50%,show that a strong EM-pulse induces sliding of a sample of rock (granite,basalt,labradorite)placed on the supporting sample which is inclined at the slope close to,but less than,the critical angle with a probability 0.07

Monitoring the Efficacy of Treatment in Children with Risk of Asthma

Asthma is the most common chronic disease of childhood throughout the world including Georgia. The tendency of substantial increase of its prevalence and severe progression is being mentioned. Prevention of the disease, as well as effective diagnostic and treatment methods have great importance for managing this problem. The modern approaches in the prevention and treatment of asthma are delivered by GINA, "Global Strategy for Asthma Management and Prevention". The main recommendations of this initiative have already been using in different countries with consideration of national peculiarities. Using leukotriene inhibitors during obstruction of respiratory system is one of the main recommendations of the project. The cysteinyl leukotrienes, LTC4, LTD4, and LTE4, play an integral role in pathophysiology of asthma [4, 7]. The unique mechanism of leukotriene receptor antagonists (LTRA) action results in a combination of both bronchodilator and anti-inflammatory effects [4. 9]. Considering the fact that optimal place of these drugs in asthma management is still under review, our work implies the monitoring of effectiveness of treatment with Montelukast, as one of the leukotrien receptor antagonist

Developing approaches to treating arterial hypertension in regard to possible pathways of angiotensin II synthesis

Aim. To study antihypertensive effects of AT1-receptor blocker eprosartan and ACE inhibitor enalapril, in regard to leading pathway of angiotensin II (AT II) synthesis among arterial hypertension (AH) patients with various functional status of renin-angiotensin-aldosterone system (RAAS). Material and methods. In total, 54 AH patients were examined. RAAS parameters and chymase activity were measured at rest and after orthostatic and captopril tests. Thirty-eight out of 54 patients were included into an open comparative cross-over two-group study, being administered eprosartan or enalapril. Antihypertensive effect was assessed after 8 weeks of treatment, by office blood pressure (BP) levels and 24-hour BP monitoring (BMP) results. Results. Basic criteria for identifying leading AT II synthesis pathway were proposed: antihypertensive reaction type in captopril test and baseline level of plasma chymase activity. Assessing eprosartan and enalapril treatment efficacy, it turned out that both agents had significant, similar antihypertensive effects, with eprosartan’s dominating influence on pulse BP. Eprosartan therapy was more effective in low-renin AH patients. Enalapril was less effective than eprosartan in patients with alternative, chymase-dependent pathway of AT II synthesis. Conclusion. Leading pathways of AT II synthesis in AH patients might be BP reduction in captopril test and baseline level of plasma chymase activity. Eprosartan therapy was more effective in low-renin and severe AH, that might be linked to its effects on alternative pathway of AT II synthesis