43 research outputs found
Superparticle Sum Rules in the presence of Hidden Sector Dynamics
We derive sum rules among scalar masses for various boundary conditions of
the hidden-visible couplings in the presence of hidden sector dynamics and show
that they still can be useful probes of the MSSM and beyond.Comment: 22 page
Detection of sentinel and non-sentinel lymph node micrometastases by complete serial sectioning and immunohistochemical analysis for gastric cancer
<p>Abstract</p> <p>Background</p> <p>We investigated the presence and distribution of the sentinel and the non-sentinel node micrometastases using complete serial sectioning and immunohistochemical staining (IHC), to inspect whether lymph node micrometastases spread to the sentinel lymph nodes first.</p> <p>Methods</p> <p>A total of 35 patients, who underwent gastrectomy with a sentinel lymph node biopsy for gastric cancer, were enrolled in this study. Total of 1028 lymph nodes of 35 patients having gastric cancer without metastasis of lymph node by permanent section with hematoxylin and eosin staining (H&E) were selected. There were 252 sentinel nodes and the other 776 were non-sentinel nodes. All nodes were sectioned serially and stained alternately with H&E and IHC. Lymph node micrometastases was defined as proving to be positive first either the IHC or the complete serial sectioning.</p> <p>Results</p> <p>Micrometastases were detected in 4 (11%) of the 35 patients, 6 (0.58%) of 1028 nodes. Of these 4 patients, 3 had micrometastases exclusively in sentinel nodes, and the other had micrometastasis in both sentinel and non-sentinel nodes. There was no patient who had the micrometasitases only in non-sentinel nodes.</p> <p>Conclusion</p> <p>These results support the concept that lymph node micrometastasis of gastric cancer spreads first to sentinel nodes.</p
Characterization of constituents, quality and stability of pomegranate seed oil (Punica granatum L.)
Clinical effects of anticancer drugs to pancreatic diseases as protein synthesis inhibitors
Strategy for designing selective α-L-rhamnosidase inhibitors: Synthesis and biological evaluation of DMDP cyclic isothioureas
This study shows that the cyclization of L-DMDP thioureas to bicyclic L-DMDP isothioureas improved a-Lrhamnosidase inhibition which was further enhanced by increasing the length of the alkyl chain. The addition of a long alkyl chain, such as decyl or dodecyl, to the nitrogen led to the production of highly potent inhibitors of a-L-rhamnosidase; it also caused broad inhibition spectrum against b-glucosidase and b-galactosidase. In contrast, the corresponding N-benzyl-L-DMDP cyclic isothioureas display selective inhibition of a-L-rhamnosidase; 30,40-dichlorobenzyl-L-DMDP cyclic isothiourea (3r) was found to display the most potent and selective inhibition of a-L-rhamnosidase, with IC50 value of 0.22 lM, about 46-fold better than the positive control 5-epi-deoxyrhamnojirimycin (5-epi-DRJ; IC50 = 10 lM) and occupied the active-site of this enzyme (Ki = 0.11 lM). Bicyclic isothioureas of ido-L-DMDP did not inhibit a-L-rhamnosidase. These new mimics of L-rhamnose may affect other enzymes associated with the biochemistry of rhamnose including enzymes involved in progression of tuberculosis.
Strategy for designing selective α-L-rhamnosidase inhibitors: Synthesis and biological evaluation of DMDP cyclic isothioureas
This study shows that the cyclization of L-DMDP thioureas to bicyclic L-DMDP isothioureas improved a-Lrhamnosidase
inhibition which was further enhanced by increasing the length of the alkyl chain. The
addition of a long alkyl chain, such as decyl or dodecyl, to the nitrogen led to the production of highly
potent inhibitors of a-L-rhamnosidase; it also caused broad inhibition spectrum against b-glucosidase
and b-galactosidase. In contrast, the corresponding N-benzyl-L-DMDP cyclic isothioureas display selective
inhibition of a-L-rhamnosidase; 30,40-dichlorobenzyl-L-DMDP cyclic isothiourea (3r) was found to display
the most potent and selective inhibition of a-L-rhamnosidase, with IC50 value of 0.22 lM, about 46-fold
better than the positive control 5-epi-deoxyrhamnojirimycin (5-epi-DRJ; IC50 = 10 lM) and occupied the
active-site of this enzyme (Ki = 0.11 lM). Bicyclic isothioureas of ido-L-DMDP did not inhibit a-L-rhamnosidase.
These new mimics of L-rhamnose may affect other enzymes associated with the biochemistry
of rhamnose including enzymes involved in progression of tuberculosis.
Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors
© 2014 Elsevier Ltd. All rights reserved. We report the isolation and structural determination of fourteen iminosugars, containing five pyrrolizidines and five indolizidines, from Castanospermum australe. The structure of a new alkaloid was elucidated by spectroscopic methods as 6,8-diepi-castanospermine (13). Our side-by-side comparison between bicyclic and corresponding monocyclic iminosugars revealed that inhibition potency and spectrum against each enzyme are clearly changed by their core structures. Castanospermine (10) and 1-deoxynojirimycin (DNJ) have a common d-gluco configuration, and they showed the expected similar inhibition potency and spectrum. In sharp contrast, 6-epi-castanospermine (12) and 1-deoxymannojirimycin (manno-DNJ) both have the d-manno configuration but the α-mannosidase inhibition of 6-epi-castanospermine (12) was much better than that of manno-DNJ. 6,8-Diepi-castanospermine (13) could be regarded as a bicyclic derivative of talo-DNJ, but it showed a complete loss of α-galactosidase A inhibition. This behavior against α-galactosidase A is similar to that observed for 1-epi-australine (6) and altro-DMDP
The incidences of metachronous multiple gastric cancer after various types of gastrectomy: analysis of data from a nationwide Japanese survey
The diagnostic contribution of CT volumetric rendering techniques in routine practice
Computed tomography (CT) volumetric rendering techniques such as maximum intensity projection (MIP), minimum intensity projection (MinIP), shaded surface display (SSD), volume rendering (VR), and virtual endoscopy (VE) provide added diagnostic capabilities. The diagnostic value of such reconstruction techniques is well documented in literature. These techniques permit the exploration of fine anatomical detail that would be difficult to evaluate using axial reconstructions alone. Although these techniques are now widely available, many radiologists are either unfamiliar with them or do not fully utilize their potential in daily clinical practice. This paper is intended to provide an overview of the most common CT volumetric rendering techniques and their practical use in everyday diagnostics