30 research outputs found
Comorbidity analysis and 3 months functional outcome in acute ischemic stroke: Data from Acute Stroke Registry and Analysis of Lausanne (ASTRAL)
Predictive value of the ASTRAL score, the Charlson and the Elixhauser comorbidity indexes in acute ischemic stroke
Comorbidity analysis and long-term mortality in acute ischemic stroke: Data from the Acute STroke Registry and Analysis of Lausanne (ASTRAL)
Association of circadian blood pressure and heart rate patterns with severity of acute ischemic stroke: Preliminary results
Prognostic value of 24-h ABPM in acute ischemic stroke: A systematic review and meta-analysis
Prognostic significance of 24-h blood pressure and variability indices in the outcome of acute ischaemic stroke
Background: The association between blood pressure (BP) levels and BP variability (BPV) following acute ischaemic stroke (AIS) and outcome remains controversial. Aims: To investigate the predictive value of systolic BP (SBP) and diastolic BP (DBP) and BPV measured using 24-h ambulatory blood pressure monitoring (ABPM) methods during AIS regarding outcome. Methods: A total of 228 AIS patients (175 without prior disability) underwent ABPM every 20 min within 48 h from onset using an automated oscillometric device (TM 2430, A&D Company Ltd) during day time (7:00–22:59) and night time (23:00–6:59). Risk factors, stroke subtypes, clinical and laboratory findings were recorded. Mean BP parameters and several BPV indices were calculated. End-points were death and unfavourable functional outcome (disability/death) at 3 months. Results: A total of 61 (26.7%) patients eventually died. Multivariate logistic regression analysis revealed that only mean night-time DBP (hazard ratio (HR): 1.04; 95% confidence interval (CI): 1.00–1.07) was an independent prognostic factor of death. Of the 175 patients without prior disability, 79 (45.1%) finally met the end-point of unfavourable functional outcome. Mean 24-h SBP (HR: 1.03; 95% CI: 1.00–1.05), day-time SBP (HR: 1.02; 95% CI: 1.00–1.05) and night-time SBP (HR: 1.03; 95% CI: 1.01–1.05), SBP nocturnal decline (HR: 0.93; 95% CI: 0.88–0.99), mean 24-h DBP (HR: 1.08; 95% CI: 1.03–1.13), day-time DBP (HR: 1.07; 95% CI: 1.03–1.12) and night-time DBP (HR: 1.06; 95% CI: 1.02–1.10) were independent prognostic factors of an unfavourable functional outcome. Conclusions: In contrast with BPV indices, ABPM-derived BP levels and lower or absence of BP nocturnal decline in the acute phase are prognostic factors of outcome in AIS patients. © 2022 Royal Australasian College of Physicians