A probabilistic extension of UML statecharts: specification and verification

This paper is the extended technical report that corresponds to a published paper [14]. This paper introduces means to specify system randomness within UML statecharts, and to verify probabilistic temporal properties over such enhanced statecharts which we call probabilistic UML statecharts. To achieve this, we develop a general recipe to extend a statechart semantics with discrete probability distributions, resulting in Markov decision processes as semantic models. We apply this recipe to the requirements-level UML semantics of [8]. Properties of interest for probabilistic statecharts are expressed in PCTL, a probabilistic variant of CTL for processes that exhibit both non-determinism and probabilities. Verification is performed using the model checker Prism. A model checking example shows the feasibility of the suggested approach

Information Storage and Retrieval for Probe Storage using Optical Diffraction Patterns

A novel method for fast information retrieval from a probe storage device is considered. It is shown that information can be stored and retrieved using the optical diffraction patterns obtained by the illumination of a large array of cantilevers by a monochromatic light source. In thermo-mechanical probe storage, the information is stored as a sequence of indentations on the polymer medium. To retrieve the information, the array of probes is actuated by applying a bending force to the cantilevers. Probes positioned over indentations experience deflection by the depth of the indentation, probes over the flat media remain un-deflected. Thus the array of actuated probes can be viewed as an irregular optical grating, which creates a data-dependent diffraction pattern when illuminated by laser light. We develop a low complexity modulation scheme, which allows the extraction of information stored in the pattern of indentations on the media from Fourier coefficients of the intensity of the diffraction pattern. We then derive a low-complexity maximum likelihood sequence detection algorithm for retrieving the user information from the Fourier coefficients. The derivation of both the modulation and the detection schemes is based on the Fraunhofer formula for data-dependent diffraction patterns. We show that for as long as the Fresnel number F<0.1, the optimal channel detector derived from Fraunhofer diffraction theory does not suffer any significant performance degradation.Comment: 14 pages, 11 figures. Version 2: minor misprints corrected, experimental section expande

De rol van circulerende tumorcellen bij het urotheelcarcinoom van de blaas

Patients with muscle-invasive urothelial cell carcinoma of the bladder have a 50 % chance to develop distant metastases despite curative local treatment. Reliable markers that predict the risk of developing metastases or that could be used to determine whether or not perioperative systemic treatment should be given are lacking. Circulating tumor cells (CTCs) are cancer cells that are present in the blood stream of patients with solid tumors and originate from tumor lesions that are present in the body. The enumeration of CTCs is an attractive option to assess the chance to develop distant metastases in individual patients. Here, we set out to review the most relevant literature to date regarding the clinical value of CTCs in bladder cancer. Moreover, the CirGuidance study is presented, which is the first interventional trial, which uses CTCs to guide treatment choices regarding the administration of neoadjuvant chemotherapy in patients with muscle-invasive urothelial cell carcinoma

BRST quantization of the pure spinor superstring

We present a derivation of the scattering amplitude prescription for the pure spinor superstring from first principles, both in the minimal and non-minimal formulations, and show that they are equivalent. This is achieved by first coupling the worldsheet action to topological gravity and then proceeding to BRST quantize this system. Our analysis includes the introduction of constant ghosts and associated auxiliary fields needed to gauge fix symmetries associated with zero modes. All fields introduced in the process of quantization can be integrated out explicitly, resulting in the prescriptions for computing scattering amplitudes that have appeared previously in the literature. The zero mode insertions in the path integral follow from the integration over the constant auxiliary fields.Comment: 31 page