Oxygen and carbon isotope imaging of organics from Y793495 (CR2) and Murchison (CM2).

第2回極域科学シンポジウム/第34回南極隕石シンポジウム 11月17日（木） 国立国語研究所 2階講

mu-Crystallin as an intracellular 3,5,3 '-triiodothyronine holder in vivo

ArticleMOLECULAR ENDOCRINOLOGY. 21(4): 885-894 (2007)journal articl

Chondrosarcoma and Peroxisome Proliferator-Activated Receptor

Induction of differentiation and apoptosis in cancer cells by ligands of PPARγ is a novel therapeutic approach to malignant tumors. Chondrosarcoma (malignant cartilage tumor) and OUMS-27 cells (cell line established from grade III human chondrosarcoma) express PPARγ. PPARγ ligands inhibited cell proliferation in a dose-dependent manner, and induced apoptosis of OUMS-27. The higher-grade chondrosarcoma expressed a higher amount of antiapoptotic Bcl-xL in vivo. The treatment of OUMS-27 by 15d-PGJ2, the most potent endogenous ligand for PPARγ, downregulated expression of Bcl-xL and induced transient upregulation of proapoptotic Bax, which could accelerate cytochrome c release from mitochondria to the cytosol, followed by induction of caspase-dependent apoptosis. 15d-PGJ2 induced the expression of CDK inhibitor p21 protein in human chondrosarcoma cells, which appears to be involved in the mechanism of inhibition of cell proliferation. These findings suggest that targeted therapy with PPARγ ligands could be a novel strategy against chondrosarcoma

An integrable BC(n) Sutherland model with two types of particles

A hyperbolic BC(n) Sutherland model involving three independent coupling constants that characterize the interactions of two types of particles moving on the half-line is derived by Hamiltonian reduction of the free geodesic motion on the group SU(n,n). The symmetry group underlying the reduction is provided by the direct product of the fixed point subgroups of two commuting involutions of SU(n,n). The derivation implies the integrability of the model and yields a simple algorithm for constructing its solutions.Comment: 14 pages, with minor modifications in v