A Marketing research study for a modified business center concept model for Lee Designs Inds., Inc.- LUXUS® first.original

This paper is a descriptive study that determined if the modified business center concept model of Luxus Inc. is acceptable to its target market. This paper analyzed three industries: the furniture, the virtual office, and the business center industries. To analyze the industries problems, competitive advantage, and the opportunities they present, the STEEPLE analysis, Porters Five Forces Framework, and the SWOT matrix were utilized. It was determined that the intelligent office industry, composed of the virtual office and business center industries, is an emerging industry. This paper tackled how the opportunities present in the rise of the intelligent office industry can be taken advantage of by the furniture industry. This paper likewise determined the target market of the intelligent office industry, their extent of awareness and experience, and their willingness to try new work settings. This paper also determined what services the modified business center should offer and at what optimal price range they should offer them. Finally, the paper determined the location that the target market prefers the modified business center to be situated at

Kaempferol Attenuates Myocardial Ischemic Injury via Inhibition of MAPK Signaling Pathway in Experimental Model of Myocardial Ischemia-Reperfusion Injury

Kaempferol (KMP), a dietary flavonoid, has antioxidant, anti-inflammatory, and antiapoptotic effects. Hence, we investigated the effect of KMP in ischemia-reperfusion (IR) model of myocardial injury in rats. We studied male albino Wistar rats that were divided into sham, IR-control, KMP-20 + IR, and KMP 20 per se groups. KMP (20 mg/kg; i.p.) was administered daily to rats for the period of 15 days, and, on the 15th day, ischemia was produced by one-stage ligation of left anterior descending coronary artery for 45 min followed by reperfusion for 60 min. After completion of surgery, rats were sacrificed; heart was removed and processed for biochemical, morphological, and molecular studies. KMP pretreatment significantly ameliorated IR injury by maintaining cardiac function, normalizing oxidative stress, and preserving morphological alterations. Furthermore, there was a decrease in the level of inflammatory markers (TNF-α, IL-6, and NFκB), inhibition of active JNK and p38 proteins, and activation of ERK1/ERK2, a prosurvival kinase. Additionally, it also attenuated apoptosis by reducing the expression of proapoptotic proteins (Bax and Caspase-3), TUNEL positive cells, and increased level of antiapoptotic proteins (Bcl-2). In conclusion, KMP protected against IR injury by attenuating inflammation and apoptosis through the modulation of MAPK pathway