865 research outputs found
Quasi-Localization of Gravity by Resonant Modes
We examine the behaviour of gravity in brane theories with extra dimensions
in a non-factorizable geometry. We find that for metrics which are
asymptotically flat far from the brane there is a resonant graviton mode at
zero energy. The presence of this resonance ensures quasi-localization of
gravity, whereby at intermediate scales the gravitational laws on the brane are
approximately four dimensional. However, for scales larger than the lifetime of
the graviton resonance the five dimensional laws of gravity will be reproduced
due to the decay of the four dimensional graviton. We also present a simple
classification of the possible types of effective gravity theories on the brane
that can appear for general non-factorizable background theories.Comment: 8 pages, 3 figures included. Requires JHEP.cls. Typos fixed, note and
references added. Added expression for width of resonanc
How Well Does AdS/QCD Describe QCD?
AdS/QCD is an extra-dimensional approach to modeling hadronic physics,
motivated by the AdS/CFT correspondence in string theory. AdS/QCD models are
often more accurate than would have been expected at energies below a few GeV.
We address the question of why these models are so successful, and respond to
some of the criticisms that have been waged against these models.Comment: To appear in proceedings of Crossing the Boundaries: Gauge Dynamics
at Strong Coupling (Shifmania), Minnesota, May 14-17, 2009. 12 pages, 2 eps
figure
Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric research and treatment
Joseph A Boscarino1,2, Porat M Erlich1,3, Stuart N Hoffman4, Xiaopeng Zhang51Center for Health Research, Geisinger Clinic, Danville, PA, 2Department of Psychiatry, 3Department of Medicine, Temple University School of Medicine, Philadelphia, PA, 4Department of Neurology, 5Department of Anesthesiology, Geisinger Clinic, Danville, PA, USAObjective: The study aim was to assess the cumulative burden of polymorphisms located within four genetic loci previously associated with posttraumatic stress disorder (PTSD) among outpatients at risk for PTSD.Methods: Diagnostic interviews were completed and DNA samples collected among 412 pain patients to determine if FKBP5 (rs9470080), COMT (rs4680), CHRNA5 (rs16969968), and CRHR1 (rs110402) single nucleotide polymorphisms were cumulatively associated with increased risk for PTSD.Results: In bivariate analyses, it was found that a count of specific PTSD risk alleles located within FKBP5, COMT, CHRNA5, and CRHR1 genetic loci (allele range = 0–6, mean count = 2.92, standard deviation = 1.36) was associated with lifetime (t [409] = 3.430, P = 0.001) and early onset PTSD (t [409] = 4.239, P = 0.000028). In logistic regression, controlling for demographic factors, personality traits, and trauma exposures, this risk allele count remained associated with both lifetime (odds ratio = 1.49, P = 0.00158) and early onset PTSD (odds ratio = 2.36, P = 0.000093). Interaction effects were also detected, whereby individuals with higher risk allele counts and higher trauma exposures had an increased risk of lifetime PTSD (allele count × high trauma, P = 0.026) and early onset PTSD (allele count × high trauma, P = 0.016) in these logistic regressions. Those with no or few risk alleles appeared resilient to PTSD, regardless of exposure history.Conclusion: A cumulative risk allele count involving four single nucleotide polymorphisms located within the FKBP5, COMT, CHRNA5, and CRHR1 genes are associated with PTSD. Level of trauma exposure interacts with risk allele count, such that PTSD is increased in those with higher risk allele counts and higher trauma exposures. Since the single nucleotide polymorphisms studied encompass stress circuitry and addiction biology, these findings may have implications for neuropsychiatric research and treatment.Keywords: posttraumatic stress disorder, genetic association study, single nucleotide polymorphism, risk alleles, trauma exposure, neuroticism, childhood adversit
Dynamically Warped Theory Space and Collective Supersymmetry Breaking
We study deconstructed gauge theories in which a warp factor emerges
dynamically and naturally. We present nonsupersymmetric models in which the
potential for the link fields has translational invariance, broken only by
boundary effects that trigger an exponential profile of vacuum expectation
values. The spectrum of physical states deviates exponentially from that of the
continuum for large masses; we discuss the effects of such exponential towers
on gauge coupling unification. We also present a supersymmetric example in
which a warp factor is driven by Fayet-Iliopoulos terms. The model is peculiar
in that it possesses a global supersymmetry that remains unbroken despite
nonvanishing D-terms. Inclusion of gravity and/or additional messenger fields
leads to the collective breaking of supersymmetry and to unusual phenomenology.Comment: 28 pages LaTeX, JHEP format, 7 eps figures (v2: reference added
Seiberg-Witten Description of the Deconstructed 6D (0,2) Theory
It has recently been suggested that, in a large N limit, a particular four
dimensional gauge theory is indistinguishable from the six dimensional CFT with
(0,2) supersymmetry compactified on a torus. We give further evidence for this
correspondence by studying the Seiberg-Witten curve for the "deconstructed"
theory and demonstrating that along the reduced Coulomb branch of moduli space
(on the intersection of the Higgs and Coulomb branches) it describes the low
energy physics on a stack of M5-branes on a torus, which is the (0,2) theory on
a torus as claimed. The M-theory construction helps to clarify the enhancement
of supersymmetry in the deconstructed theory at low energies, and demonstrates
its stability to radiative and instanton corrections. We demonstrate the role
of the theta vacuum in the deconstructed theory. We point out that by varying
the theta parameters and gauge couplings in the deconstructed theory, the
complex structure of the torus can be chosen arbitrarily, and the torus is not
metrically S^1 x S^1 in general.Comment: 13 pages, 2 figure
On the Evaluation of Gluon Condensate Effects in the Holographic Approach to QCD
In holographic QCD the effects of gluonic condensate can be encoded in a
suitable deformation of the 5D metric. We develop two different methods for the
evaluation of first order perturbative corrections to masses and decay
constants of vector resonances in 5D Hard-Wall models of QCD due to small
deformations of the metric. They are extracted either from a novel compact form
for the first order correction to the vector two-point function, or from
perturbation theory for vector bound-state eigenfunctions: the equivalence of
the two methods is shown. Our procedures are then applied to flat and to AdS 5D
Hard-Wall models; we complement results of existing literature evaluating the
corrections to vector decay constant and to two-pion-one-vector couplings: this
is particularly relevant to satisfy the sum rules. We concentrate our attention
on the effects for the Gasser-Leutwyler coefficients; we show that, as in the
Chiral Quark model, the addition of the gluonic condensate improves the
consistency, the understanding and the agreement with phenomenology of the
holographic model.Comment: 23 pages, three figures, sign error in pion wave function fixed,
numerical analysis extended, general conclusions unchange
Little Technicolor
Inspired by the AdS/CFT correspondence, we show that any G/H symmetry
breaking pattern can be described by a simple two-site moose diagram. This
construction trivially reproduces the CCWZ prescription in the context of
Hidden Local Symmetry. We interpret this moose in a novel way to show that many
little Higgs theories can emerge from ordinary chiral symmetry breaking in
scaled-up QCD. We apply this reasoning to the simple group little Higgs to see
that the same low energy degrees of freedom can arise from a variety of UV
complete theories. We also show how models of holographic composite Higgs
bosons can turn into brane-localized little technicolor theories by
"integrating in" the IR brane.Comment: 26 pages, 2 figures; v2: references added; v3: added section on
vacuum alignment to match JHEP versio
Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity
Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages in mice promotes bacterial clearance in the peritoneal cavity and serves to facilitate the well-known but poorly understood macrophage disappearance reaction. Intravital imaging revealed that resident macrophages were nonadherent in peritoneal fluid during homeostasis. Bacterial entry into the peritoneum acutely induced macrophage adherence and associated bacterial phagocytosis. However, optimal control of bacterial expansion in the peritoneum also required expression of FV by the macrophages to form local clots that effectively brought macrophages and bacteria in proximity and out of the fluid phase. Thus, acute cellular adhesion and resident macrophage-induced coagulation operate independently and cooperatively to meet the challenges of a unique, open tissue environment. These events collectively account for the macrophage disappearance reaction in the peritoneal cavity
Matrix Models, Monopoles and Modified Moduli
Motivated by the Dijkgraaf-Vafa correspondence, we consider the matrix model
duals of N=1 supersymmetric SU(Nc) gauge theories with Nf flavors. We
demonstrate via the matrix model solutions a relation between vacua of theories
with different numbers of colors and flavors. This relation is due to an N=2
nonrenormalization theorem which is inherited by these N=1 theories.
Specializing to the case Nf=Nc, the simplest theory containing baryons, we
demonstrate that the explicit matrix model predictions for the locations on the
Coulomb branch at which monopoles condense are consistent with the quantum
modified constraints on the moduli in the theory. The matrix model solutions
include the case that baryons obtain vacuum expectation values. In specific
cases we check explicitly that these results are also consistent with the
factorization of corresponding Seiberg-Witten curves. Certain results are
easily understood in terms of M5-brane constructions of these gauge theories.Comment: 27 pages, LaTeX, 2 figure
4D Constructions of Supersymmetric Extra Dimensions and Gaugino Mediation
We present 4D gauge theories which at low energies coincide with higher
dimensional supersymmetric (SUSY) gauge theories on a transverse lattice. We
show that in the simplest case of pure 5D SUSY Yang-Mills there is an
enhancement of SUSY in the continuum limit without fine-tuning. This result no
longer holds in the presence of matter fields, in which case fine-tuning is
necessary to ensure higher dimensional Lorentz invariance and supersymmetry. We
use this construction to generate 4D models which mimic gaugino mediation of
SUSY breaking. The way supersymmetry breaking is mediated in these models to
the MSSM is by assuming that the physical gauginos are a mixture of a number of
gauge eigenstate gauginos: one of these couples to the SUSY breaking sector,
while another couples to the MSSM matter fields. The lattice can be as coarse
as just two gauge groups while still obtaining the characteristic
gaugino-mediated soft breaking terms.Comment: 32 pages LaTeX; missing factor in two-loop gauge-mediated scalar mass
estimate fixed, comments on unification revise
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