Quasi-Localization of Gravity by Resonant Modes

We examine the behaviour of gravity in brane theories with extra dimensions in a non-factorizable geometry. We find that for metrics which are asymptotically flat far from the brane there is a resonant graviton mode at zero energy. The presence of this resonance ensures quasi-localization of gravity, whereby at intermediate scales the gravitational laws on the brane are approximately four dimensional. However, for scales larger than the lifetime of the graviton resonance the five dimensional laws of gravity will be reproduced due to the decay of the four dimensional graviton. We also present a simple classification of the possible types of effective gravity theories on the brane that can appear for general non-factorizable background theories.Comment: 8 pages, 3 figures included. Requires JHEP.cls. Typos fixed, note and references added. Added expression for width of resonanc

How Well Does AdS/QCD Describe QCD?

AdS/QCD is an extra-dimensional approach to modeling hadronic physics, motivated by the AdS/CFT correspondence in string theory. AdS/QCD models are often more accurate than would have been expected at energies below a few GeV. We address the question of why these models are so successful, and respond to some of the criticisms that have been waged against these models.Comment: To appear in proceedings of Crossing the Boundaries: Gauge Dynamics at Strong Coupling (Shifmania), Minnesota, May 14-17, 2009. 12 pages, 2 eps figure

Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric research and treatment

Joseph A Boscarino1,2, Porat M Erlich1,3, Stuart N Hoffman4, Xiaopeng Zhang51Center for Health Research, Geisinger Clinic, Danville, PA, 2Department of Psychiatry, 3Department of Medicine, Temple University School of Medicine, Philadelphia, PA, 4Department of Neurology, 5Department of Anesthesiology, Geisinger Clinic, Danville, PA, USAObjective: The study aim was to assess the cumulative burden of polymorphisms located within four genetic loci previously associated with posttraumatic stress disorder (PTSD) among outpatients at risk for PTSD.Methods: Diagnostic interviews were completed and DNA samples collected among 412 pain patients to determine if FKBP5 (rs9470080), COMT (rs4680), CHRNA5 (rs16969968), and CRHR1 (rs110402) single nucleotide polymorphisms were cumulatively associated with increased risk for PTSD.Results: In bivariate analyses, it was found that a count of specific PTSD risk alleles located within FKBP5, COMT, CHRNA5, and CRHR1 genetic loci (allele range = 0–6, mean count = 2.92, standard deviation = 1.36) was associated with lifetime (t [409] = 3.430, P = 0.001) and early onset PTSD (t [409] = 4.239, P = 0.000028). In logistic regression, controlling for demographic factors, personality traits, and trauma exposures, this risk allele count remained associated with both lifetime (odds ratio = 1.49, P = 0.00158) and early onset PTSD (odds ratio = 2.36, P = 0.000093). Interaction effects were also detected, whereby individuals with higher risk allele counts and higher trauma exposures had an increased risk of lifetime PTSD (allele count × high trauma, P = 0.026) and early onset PTSD (allele count × high trauma, P = 0.016) in these logistic regressions. Those with no or few risk alleles appeared resilient to PTSD, regardless of exposure history.Conclusion: A cumulative risk allele count involving four single nucleotide polymorphisms located within the FKBP5, COMT, CHRNA5, and CRHR1 genes are associated with PTSD. Level of trauma exposure interacts with risk allele count, such that PTSD is increased in those with higher risk allele counts and higher trauma exposures. Since the single nucleotide polymorphisms studied encompass stress circuitry and addiction biology, these findings may have implications for neuropsychiatric research and treatment.Keywords: posttraumatic stress disorder, genetic association study, single nucleotide polymorphism, risk alleles, trauma exposure, neuroticism, childhood adversit

Dynamically Warped Theory Space and Collective Supersymmetry Breaking

We study deconstructed gauge theories in which a warp factor emerges dynamically and naturally. We present nonsupersymmetric models in which the potential for the link fields has translational invariance, broken only by boundary effects that trigger an exponential profile of vacuum expectation values. The spectrum of physical states deviates exponentially from that of the continuum for large masses; we discuss the effects of such exponential towers on gauge coupling unification. We also present a supersymmetric example in which a warp factor is driven by Fayet-Iliopoulos terms. The model is peculiar in that it possesses a global supersymmetry that remains unbroken despite nonvanishing D-terms. Inclusion of gravity and/or additional messenger fields leads to the collective breaking of supersymmetry and to unusual phenomenology.Comment: 28 pages LaTeX, JHEP format, 7 eps figures (v2: reference added

Seiberg-Witten Description of the Deconstructed 6D (0,2) Theory

It has recently been suggested that, in a large N limit, a particular four dimensional gauge theory is indistinguishable from the six dimensional CFT with (0,2) supersymmetry compactified on a torus. We give further evidence for this correspondence by studying the Seiberg-Witten curve for the "deconstructed" theory and demonstrating that along the reduced Coulomb branch of moduli space (on the intersection of the Higgs and Coulomb branches) it describes the low energy physics on a stack of M5-branes on a torus, which is the (0,2) theory on a torus as claimed. The M-theory construction helps to clarify the enhancement of supersymmetry in the deconstructed theory at low energies, and demonstrates its stability to radiative and instanton corrections. We demonstrate the role of the theta vacuum in the deconstructed theory. We point out that by varying the theta parameters and gauge couplings in the deconstructed theory, the complex structure of the torus can be chosen arbitrarily, and the torus is not metrically S^1 x S^1 in general.Comment: 13 pages, 2 figure

On the Evaluation of Gluon Condensate Effects in the Holographic Approach to QCD

In holographic QCD the effects of gluonic condensate can be encoded in a suitable deformation of the 5D metric. We develop two different methods for the evaluation of first order perturbative corrections to masses and decay constants of vector resonances in 5D Hard-Wall models of QCD due to small deformations of the metric. They are extracted either from a novel compact form for the first order correction to the vector two-point function, or from perturbation theory for vector bound-state eigenfunctions: the equivalence of the two methods is shown. Our procedures are then applied to flat and to AdS 5D Hard-Wall models; we complement results of existing literature evaluating the corrections to vector decay constant and to two-pion-one-vector couplings: this is particularly relevant to satisfy the sum rules. We concentrate our attention on the effects for the Gasser-Leutwyler coefficients; we show that, as in the Chiral Quark model, the addition of the gluonic condensate improves the consistency, the understanding and the agreement with phenomenology of the holographic model.Comment: 23 pages, three figures, sign error in pion wave function fixed, numerical analysis extended, general conclusions unchange

Little Technicolor

Inspired by the AdS/CFT correspondence, we show that any G/H symmetry breaking pattern can be described by a simple two-site moose diagram. This construction trivially reproduces the CCWZ prescription in the context of Hidden Local Symmetry. We interpret this moose in a novel way to show that many little Higgs theories can emerge from ordinary chiral symmetry breaking in scaled-up QCD. We apply this reasoning to the simple group little Higgs to see that the same low energy degrees of freedom can arise from a variety of UV complete theories. We also show how models of holographic composite Higgs bosons can turn into brane-localized little technicolor theories by "integrating in" the IR brane.Comment: 26 pages, 2 figures; v2: references added; v3: added section on vacuum alignment to match JHEP versio

Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity

Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages in mice promotes bacterial clearance in the peritoneal cavity and serves to facilitate the well-known but poorly understood macrophage disappearance reaction. Intravital imaging revealed that resident macrophages were nonadherent in peritoneal fluid during homeostasis. Bacterial entry into the peritoneum acutely induced macrophage adherence and associated bacterial phagocytosis. However, optimal control of bacterial expansion in the peritoneum also required expression of FV by the macrophages to form local clots that effectively brought macrophages and bacteria in proximity and out of the fluid phase. Thus, acute cellular adhesion and resident macrophage-induced coagulation operate independently and cooperatively to meet the challenges of a unique, open tissue environment. These events collectively account for the macrophage disappearance reaction in the peritoneal cavity

Matrix Models, Monopoles and Modified Moduli

Motivated by the Dijkgraaf-Vafa correspondence, we consider the matrix model duals of N=1 supersymmetric SU(Nc) gauge theories with Nf flavors. We demonstrate via the matrix model solutions a relation between vacua of theories with different numbers of colors and flavors. This relation is due to an N=2 nonrenormalization theorem which is inherited by these N=1 theories. Specializing to the case Nf=Nc, the simplest theory containing baryons, we demonstrate that the explicit matrix model predictions for the locations on the Coulomb branch at which monopoles condense are consistent with the quantum modified constraints on the moduli in the theory. The matrix model solutions include the case that baryons obtain vacuum expectation values. In specific cases we check explicitly that these results are also consistent with the factorization of corresponding Seiberg-Witten curves. Certain results are easily understood in terms of M5-brane constructions of these gauge theories.Comment: 27 pages, LaTeX, 2 figure

4D Constructions of Supersymmetric Extra Dimensions and Gaugino Mediation

We present 4D gauge theories which at low energies coincide with higher dimensional supersymmetric (SUSY) gauge theories on a transverse lattice. We show that in the simplest case of pure 5D SUSY Yang-Mills there is an enhancement of SUSY in the continuum limit without fine-tuning. This result no longer holds in the presence of matter fields, in which case fine-tuning is necessary to ensure higher dimensional Lorentz invariance and supersymmetry. We use this construction to generate 4D models which mimic gaugino mediation of SUSY breaking. The way supersymmetry breaking is mediated in these models to the MSSM is by assuming that the physical gauginos are a mixture of a number of gauge eigenstate gauginos: one of these couples to the SUSY breaking sector, while another couples to the MSSM matter fields. The lattice can be as coarse as just two gauge groups while still obtaining the characteristic gaugino-mediated soft breaking terms.Comment: 32 pages LaTeX; missing factor in two-loop gauge-mediated scalar mass estimate fixed, comments on unification revise