Nomenclature adjustments and new syntaxa of the arctic, alpine and oro-Mediterranean vegetation

Proposte sintassonomiche e nomenclaturali per la vegetazione della Tundra alpina. Il capitolo riguardante l'alta quota appenninica è il più corposo e propone il nuovo syntaxon Leontopodio-Elynion a livello di alleanza. La grande novità sta nel fatto che questa alleanza è da considerarsi anfi-Adriatica e unsice Appennino e balcani, differenziandosi dall'alleanza già definita da altri per le Alpi. i Pirenei e i Carpazi.During preparation of the European checklist of vegetation units (EuroVegChecklist), it became clear that some earlier described syntaxa need to be typified in order to stabilize nomenclature and some new syntaxa need to be described. Here we propose nomenclature adjustments and formal description of four new alliances for the Arctic, alpine and oro-Mediterranean vegetation of Europe, Greenland and Anatolia. First, we typify the class Juncetea trifidi. Second, we describe four new alliances, such as the Puccinellion nuttallianae (Low-Arctic salt steppes of Greenland; class Saxifrago tricuspidatae-Calamagrostietea purpurascentis), Dryado octopetalae- Caricion arctisibiricae (Arctic tundra vegetation of north-eastern European Russia; class Carici rupestris-Kobresietea bellardii), Leontopodio nivalis-Elynion myosuroidis (southern European alpine tundra vegetation; class Carici rupestris-Kobresietea bellardii) and Lagotido uralensis-Caricion ensifoliae (alpine tundra vegetation of the Southern Ural Mountains; class Juncetea trifidi). Two new associations are described within the first two of these alliances. Finally, we present an interpretation of the alliance Muscario-Scillion nivalis

Evidence from multivariate morphometric study of the quercus pubescens complex in southeast Italy

The name Quercus pubescens s.l. encompasses a complex of deciduous oak taxa with mainly southeastEuropean distribution and a large ecological niche. As the easternmost region of Italy, Apulia is rather isolated from a geographical and physiographical viewpoint and counts the highest number of oak species (10). In the taxonomic and phytosociological literature, the occurrence of several species belonging to the Quercus pubescens collective group is reported for this region. In order to verify if different sets of morphological characters are associated with different taxa, 24 populations of Quercus pubescens s.l. located in different ecological-geographical areas of Apulia were sampled. A total of 367 trees, 4254 leaves and 1120 fruits were collected and morphologically analysed. Overall, 25 morphological characters of oak leaves and fruits were statistically treated using both univariate and multivariate analysis. Nested ANOVA showed that leaves collected from a single tree exhibited a degree of morphological variability higher than that observed when comparing leaves coming from different trees of the same population and from different trees of different populations as well. Almost all the morphological characters analysed exhibited a continuous trend of variation so that none of them can be used as a character to discriminate between populations. Only leaf and fruit “size” and fruit petiole length emerged as slightly discriminating characters. Our results suggest that it is unlikely that more than one species belonging to the Quercus pubescens complex occurs in the Apulia region. Comparison between the Apulian populations and a genetically pure Q. pubescens population coming from a different area (the Molise region) strengthened the assumption as to the existence of a single species that can provisionally be classified under the name of Q. pubescens s.

Natural disasters and university enrolment: Evidence from L’Aquila earthquake

Although there are several studies looking at the effect of natural disasters on economic growth, less attention has been dedicated to their impact on educational outcomes, especially in more developed countries. We use the synthetic control method to examine how the L’Aquila earthquake affected subsequent enrolment at the local university. This issue has wide economic implications as the University of L’Aquila made a large contribution to the local economy before the earthquake. Our results indicate that the earthquake had no statistically significant effect on first-year enrolment at the University of L’Aquila in the three academic years after the disaster. This natural disaster, however, caused a compositional change in the first-year student population, with a substantial increase in the number of students aged 21 or above. This is likely to have been driven by post-disaster measures adopted in order to mitigate the expected negative effects on enrolment triggered by the earthquake

BCR-ABL residues interacting with ponatinib are critical to preserve the tumorigenic potential of the oncoprotein

Patients with chronic myeloid leukemia in whom tyrosine kinase inhibitors (TKIs) fail often present mutations in the BCR-ABL catalytic domain. We noticed a lack of substitutions involving 4 amino acids (E286, M318, I360, and D381) that form hydrogen bonds with ponatinib. We therefore introduced mutations in each of these residues, either preserving or altering their physicochemical properties. We found that E286, M318, I360, and D381 are dispensable for ABL and BCR-ABL protein stability but are critical for preserving catalytic activity. Indeed, only a "conservative" I360T substitution retained kinase proficiency and transforming potential. Molecular dynamics simulations of BCR-ABLI360T revealed differences in both helix αC dynamics and protein-correlated motions, consistent with a modified ATP-binding pocket. Nevertheless, this mutant remained sensitive to ponatinib, imatinib, and dasatinib. These results suggest that changes in the 4 BCR-ABL residues described here would be selected against by a lack of kinase activity or by maintained responsiveness to TKIs. Notably, amino acids equivalent to those identified in BCR-ABL are conserved in 51% of human tyrosine kinases. Hence, these residues may represent an appealing target for the design of pharmacological compounds that would inhibit additional oncogenic tyrosine kinases while avoiding the emergence of resistance due to point mutations.This work was supported by an investigator grant to P.V. from Associazione Italiana per la Ricerca sul Cancro (AIRC) and by funding from the Biotechnology and Biological Sciences Research Council (BB/I023291/1 and BB/H018409/1 to AP and FF). P.B. is the recipient of an AIRC - Marie Curie fellowship

The diagnostic accuracy of the small fiber neuropathy symptoms inventory questionnaire (SFN-SIQ) for identifying pure small fiber neuropathy

A definite diagnosis of pure small fiber neuropathy (SFN) relies on specific diagnostic testing, such as skin biopsy, quantitative sensory testing (QST), and nociceptive evoked potentials, which require considerable resources that may not be widely available. Accordingly, diagnostic tools with easy implementation in non-specialist centers are warranted to identify patients who require second-level diagnostic tests. In this study, we aimed to test the accuracy of the Small Fiber Neuropathy Symptoms Inventory Questionnaire (SFN-SIQ) in diagnosing pure SFN. We enrolled 86 patients with suspected pure SFN. In these patients, we calculated the diagnostic accuracy of the SFN-SIQ using a combination of clinical examination, QST, and skin biopsy as a reference standard. We found that the SFN-SIQ showed an excellent ability to discriminate between patients with and without pure SFN, with 86% sensitivity and 70% specificity in the diagnosis of pure SFN. Our study providing the diagnostic yield of the SFN-SIQ for pure SFN diagnosis suggests that this questionnaire might be used to screen patients with suspected SFN and identify those requiring second-level diagnostic tests such as QST, skin biopsy, or nociceptive evoked potentials

Observation of Dirac plasmons in a topological insulator

Plasmons are the quantized collective oscillations of electrons in metals and doped semiconductors. The plasmons of ordinary, massive electrons are since a long time basic ingredients of research in plasmonics and in optical metamaterials. Plasmons of massless Dirac electrons were instead recently observed in a purely two-dimensional electron system (2DEG)like graphene, and their properties are promising for new tunable plasmonic metamaterials in the terahertz and the mid-infrared frequency range. Dirac quasi-particles are known to exist also in the two-dimensional electron gas which forms at the surface of topological insulators due to a strong spin-orbit interaction. Therefore,one may look for their collective excitations by using infrared spectroscopy. Here we first report evidence of plasmonic excitations in a topological insulator (Bi2Se3), that was engineered in thin micro-ribbon arrays of different width W and period 2W to select suitable values of the plasmon wavevector k. Their lineshape was found to be extremely robust vs. temperature between 6 and 300 K, as one may expect for the excitations of topological carriers. Moreover, by changing W and measuring in the terahertz range the plasmonic frequency vP vs. k we could show, without using any fitting parameter, that the dispersion curve is in quantitative agreement with that predicted for Dirac plasmons.Comment: 11 pages, 3 figures, published in Nature Nanotechnology (2013

Maintenance deep transcranial magnetic stimulation sessions are associated with reduced depressive relapses in patients with unipolar or bipolar depression

Introduction: Deep transcranial magnetic stimulation (dTMS) is a new form of TMS allowing safe stimulation of deep brain regions. The objective of this preliminary study was to assess the role of dTMS maintenance sessions in protecting patients with bipolar disorder (BD) or recurrent major depressive disorder (MDD) from developing depressive or manic relapses in a 12-month follow-up period. Methods: Twenty-four drug-resistant patients with a current depressive episode and a diagnosis of MDD or BD have been enrolled in the study. All the participants underwent daily dTMS sessions for 4 weeks. One group (maintenance - M group) received additional maintenance dTMS sessions weekly or twice a week. Results: After the first dTMS cycle, a significant reduction of Hamilton Depression Rating Scale (HDRS) scores was observed in all participants. Subsequently, the HDRS mean scores did not significantly change over time in the M group, while it significantly increased in the non-M-group after 6 and 12 months. Discussion: This study confirms previous evidence of a positive therapeutic effect of dTMS on depressive symptoms and suggests that, after recovery from acute episodes, maintenance dTMS sessions may be helpful in maintaining euthymia in a 12-month follow-up period

UVB radiation induced effects on cells studied by FTIR spectroscopy

We have made a preliminary analysis of the results about the eVects on tumoral cell line (lymphoid T cell line Jurkat) induced by UVB radiation (dose of 310 mJ/cm^2) with and without a vegetable mixture. In the present study, we have used two techniques: Fourier transform infrared spectroscopy (FTIR) and flow cytometry. FTIR spectroscopy has the potential to provide the identiWcation of the vibrational modes of some of the major compounds (lipid, proteins and nucleic acids) without being invasive in the biomaterials. The second technique has allowed us to perform measurements of cytotoxicity and to assess the percentage of apoptosis. We already studied the induction of apoptotic process in the same cell line by UVB radiation; in particular, we looked for correspondences and correlations between FTIR spetroscopy and flow cytometry data finding three highly probable spectroscopic markers of apoptosis (Pozzi et al. in Radiat Res 168:698-705, 2007). In the present work, the results have shown significant changes in the absorbance and spectral pattern in the wavenumber protein and nucleic acids regions after the treatments