203 research outputs found
Inclusive University didactics and technological devices: a case study
This paper provides a review of projects related to new technologies used to favour the teaching-learning processes and the inclusive practices in the University context for students with disabilities and with Specific Learning Disorders. Authors present a review of strategies, trajectories and perspectives activated in the national and international scene, aiming to guarantee a significant pedagogical framework of reference. Furthermore, the paper focuses on a meaningful path activated at the University of Macerata, the project Inclusion 3.0, a relevant example of new technologies in support of teaching- learning processes and inclusion practices among all students
Low disordered, stable, and shallow germanium quantum wells: a playground for spin and hybrid quantum technology
Buried-channel semiconductor heterostructures are an archetype material
platform to fabricate gated semiconductor quantum devices. Sharp confinement
potential is obtained by positioning the channel near the surface, however
nearby surface states degrade the electrical properties of the starting
material. In this paper we demonstrate a two-dimensional hole gas of high
mobility ( cm/Vs) in a very shallow strained germanium
channel, which is located only 22 nm below the surface. This high mobility
leads to mean free paths , setting new benchmarks for holes in
shallow FET devices. Carriers are confined in an undoped Ge/SiGe
heterostructure with reduced background contamination, sharp interfaces, and
high uniformity. The top-gate of a dopant-less field effect transistor controls
the carrier density in the channel. The high mobility, along with a percolation
density of , light effective mass (0.09
m), and high g-factor (up to ) highlight the potential of undoped
Ge/SiGe as a low-disorder material platform for hybrid quantum technologies
Characterization of gaze in handwriting of High and Low Frequency Word of Schoolchildren with Dyslexia
Writing is extremely important for our academic and professional life and can affect our performance in productive educational activities, favouring us or not. Schoolchildren with dyslexia bring difficulties and reduced school performance due to their condition of deprivation in written production. This is because schoolchildren with dyslexia have difficulty acquiring spelling knowledge and show poor phonological skills. This study aimed to characterize the performance of schoolchildren with dyslexia in “gaze” for the handwriting of High and Low-frequency words. A total of 24 schoolchildren participated in the study. They were between 8 to 11 years and 11 months of age, of both sexes, and they were attending the 3rd to the 5th year of Elementary School in the city of Marília-SP. The schoolchildren were divided into groups: GI, composed of 12schoolchildren with an interdisciplinary diagnosis of developmental dyslexia, and GII, composed of 12 schoolchildren with good academic performance, paired with GI according to the school grade level. These schoolchildren were submitted to computerized handwriting evaluation using a Brazilian adaptation of the Software Ductus. All schoolchildren were submitted to a copy of words already selected according to Brazilian Portuguese criteria of frequency and codification rule. A measure of “gaze” was used, that is, when the schoolchildren stopped their handwriting to search/look up at the screen to confirm the information about the words. The results indicated a significant difference between GI and GII, with GI schoolchildren performing more gaze when compared with GII, i.e., taking longer motor breaks to perform the gaze. Therefore, there was a rupture in the central processing with the peripheral when the child performed the gauze more times since he had to confirm the characteristics of this word during the writing process (difficulty in accessing the orthographic lexicon) and with that, there was a break in the movement of handwriting (since there was not enough information in the central plane to complete that motor memory and finish the word). It was concluded that there were gaps between the central (orthographic) and peripheral (motor pauses processes, suggesting deficits in the formation of motor programs for GI and the lack of automation of motor processes
Speed and pressure of handwriting as critical issues of the contemporary age: A research in Italian students in early literacy
Among the present critical issues that pedagogy and special teaching have to
deal with it is possible to notice the contrast between writing and technology,
up to the pertinent field of prevention and observation of dysgraphies. The
authors present in the following article a study conducted in Italy aimed at
evaluating writing, specifically in the speed and pressure parameters in early
literacy using NeuroScript Movalyzer Software. The aim is to implement
suitable research paths to support the dissemination of observation procedures
and inclusive teaching practices, capable of enhancing the fluidity of writing
by all students
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Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome
Metabolic syndrome is a growing health problem worldwide. It is therefore imperative to develop new strategies to treat this pathology. In the past years, the manipulation of NAD+ metabolism has emerged as a plausible strategy to ameliorate metabolic syndrome. In particular, an increase in cellular NAD+ levels has beneficial effects, likely because of the activation of sirtuins. Previously, we reported that CD38 is the primary NAD+ase in mammals. Moreover, CD38 knockout mice have higher NAD+ levels and are protected against obesity and metabolic syndrome. Here, we show that CD38 regulates global protein acetylation through changes in NAD+ levels and sirtuin activity. In addition, we characterize two CD38 inhibitors: quercetin and apigenin. We show that pharmacological inhibition of CD38 results in higher intracellular NAD+ levels and that treatment of cell cultures with apigenin decreases global acetylation as well as the acetylation of p53 and RelA-p65. Finally, apigenin administration to obese mice increases NAD+ levels, decreases global protein acetylation, and improves several aspects of glucose and lipid homeostasis. Our results show that CD38 is a novel pharmacological target to treat metabolic diseases via NAD+-dependent pathways
New data on the ichthyosaur Platypterygius hercynicus and its implications for the validity of the genus
The description of a nearly complete skull from the late Albian of northwestern France
reveals previously unknown anatomical features of Platypterygius hercynicus (Kuhn 1946),
and of European Cretaceous ichthyosaurs in general. These include a wide frontal forming the
anteromedial border of the supratemporal fenestra, a parietal excluded from the parietal
foramen, and the likely presence of a squamosal, inferred from a very large and deep facet on
the quadratojugal. The absence of a squamosal has been considered as an autapomorphy of
the genus Platypterygius for more than ten years and has been applied to all known species by
default, but the described specimen casts doubt on this putative autapomorphy. Actually, it is
shown that all characters that have been proposed previously as autapomorphic for the genus
Platypterygius are either not found in all the species currently referred to this genus, or are
also present in other Ophthalmosauridae. Consequently, the genus Platypterygius must be
completely revised.Peer reviewe
Thermoelectric power factor under strain-induced band-alignment in the half-Heuslers NbCoSn and TiCoSb
Band convergence is an effective strategy to improve the thermoelectric
performance of complex bandstructure thermoelectric materials. Half-Heuslers
are good candidates for band convergence studies because they have multiple
bands near the valence bad edge that can be converged through various band
engineering approaches providing power factor improvement opportunities.
Theoretical calculations to identify the outcome of band convergence employ
various approximations for the carrier scattering relaxation times (the most
common being the constant relaxation time approximation) due to the high
computational complexity involved in extracting them accurately. Here, we
compare the outcome of strain-induced band convergence under two such
scattering scenarios: i) the most commonly used constant relaxation time
approximation and ii) energy dependent inter- and intra-valley scattering
considerations for the half-Heuslers NbCoSn and TiCoSb. We show that the
outcome of band convergence on the power factor depends on the carrier
scattering assumptions, as well as the temperature. For both materials
examined, band convergence improves the power factor. For NbCoSn, however, band
convergence becomes more beneficial as temperature increases, under both
scattering relaxation time assumptions. In the case of TiCoSb, on the other
hand, constant relaxation time considerations also indicate that the relative
power factor improvement increases with temperature, but under the energy
dependent scattering time considerations, the relative improvement weakens with
temperature. This indicates that the scattering details need to be accurately
considered in band convergence studies to predict more accurate trends.Comment: 21 pages, 8 figures. arXiv admin note: text overlap with
arXiv:1905.0795
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