Genetic Algorithm Optimization of a High-Directivity Microstrip Patch Antenna Having a Rectangular Profile

A single high-directivity microstrip patch antenna (MPA) having a rectangular profile, which can substitute a linear array is proposed. It is designed by using genetic algorithms with the advantage of not requiring a feeding network. The patch fits inside an area of 2.54λ x 0.25λ, resulting in a broadside pattern with a directivity of 12 dBi and a fractional impedance bandwidth of 4%. The antenna is fabricated and the measurements are in good agreement with the simulated results. The genetic MPA provides a similar directivity as linear arrays using a corporate or series feeding, with the advantage that the genetic MPA results in more bandwidth

Match analysis in football: a systematic review

The main focus of this paper was to review the available literature on match analysis in adult male football. The most common research topics were identified, their methodologies described and the evolutionary tendencies of this research area systematised. A systematic review of Institute for Scientific Information (ISI) Web of Knowledge database was performed according to PRISMA (Preferred Reporting Items for Systematic reviews and Meta-analyses) guidelines. The following keywords were used: football and soccer, each one associated with the terms: match analysis, performance analysis, notational analysis, game analysis, tactical analysis and patterns of play. Of 2732 studies initially identified, only 53 were fully reviewed, and their outcome measures abstracted and analysed. Studies that fit all inclusion criteria were organised according to their research design as descriptive, comparative or predictive. Results showed that 10 studies focused predominantly on a description of technical, tactical and physical performance variables. From all comparative studies, the dependent variables more frequently used were “playing position” and “competitive level”. Even though the literature stresses the importance of developing predictive models of sports performance, only few studies (n = 8) have focused on modelling football performance. Situational variables like game location, quality of opposing teams, match status and match half have been progressively included as object of research, since they seem to work as effective covariables of football performance. Taking into account the limitations of the reviewed studies, future research should provide comprehensive operational definitions for the studied variables, use standardised categories and description of activities and participants, and consider integrating the situational and interactional contexts into the analysis of football performance

A comparative limnological study of the Guadalhorce reservoirs system (Málaga,SE.Spain)

15 páginas ; 6 Figuras ; 2 TablasA partir de 10s muestreos efectuados durante el período de mezcla (marzo de 1988) y estratificación (setiembre de 1988) en 10s tres embalses del sistema Guadalhorce, se analizan sus diferencias fisicoquimicas y biológicas. Aunque 10s tres embalses presentan un contenido de sales disueltas relativamente alto, Conde de Guadalhorce es de aguas carbonatadas, mientras que en Guadalhorce son importantes 10s cloruros y Guadalteba se encuentra en una posición intermedia. En estos dos 61- timos embalses la presencia de cloruros determina la existencia de una haloclina muy marcada, que en el caso de Guadalhorce es permanente. Desde el punto de vista de sus características tróficas, Guadalteba y Guadalhorce son eutróficos, 10 que se refleja en la alta concentración de nutrientes y pigmentos, asi como por tener respiración y ETS elevados. Por el contrario, Conde de Guadalhorce puede considerarse como mesotrófico a partir de 10s mismos parámetros, además de permanecer con oxigeno en el hipolimnion durante todo el verano.This research has been supported by the Comisión Asesora de Investigación Científica y Técnica grant nª PB85-0166 and sponsored by the Dirección General de Obras Hidráulicas of the Ministry of Public AffairsPeer reviewe

Solar Cycle Related Changes at the Base of the Convection Zone

The frequencies of solar oscillations are known to change with solar activity. We use Principal Component Analysis to examine these changes with high precision. In addition to the well-documented changes in solar normal mode oscillations with activity as a function of frequency, which originate in the surface layers of the Sun, we find a small but statistically significant change in frequencies with an origin at and below the base of the convection zone. We find that at r=(0.712^{+0.0097}_{-0.0029})R_sun, the change in sound speed is \delta c^2 / c^2 = (7.23 +/- 2.08) x 10^{-5} between high and low activity. This change is very tightly correlated with solar activity. In addition, we use the splitting coefficients to examine the latitudinal structure of these changes. We find changes in sound speed correlated with surface activity for r >~ 0.9R_sun.Comment: 29 pages, 11 figures, accepted for publication in Ap

Disruption of cortical cell type composition and function underlies diabetes-associated cognitive decline

Aims/hypothesis Type 2 diabetes is associated with increased risk of cognitive decline although the pathogenic basis for this remains obscure. Deciphering diabetes-linked molecular mechanisms in cells of the cerebral cortex could uncover novel therapeutic targets. Methods Single-cell transcriptomic sequencing (scRNA-seq) was conducted on the cerebral cortex in a mouse model of type 2 diabetes (db/db mice) and in non-diabetic control mice in order to identify gene expression changes in distinct cell subpopulations and alterations in cell type composition. Immunohistochemistry and metabolic assessment were used to validate the fndings from scRNA-seq and to investigate whether these cell-specifc dysfunctions impact the neurovascular unit (NVU). Furthermore, the behavioural and cognitive alterations related to these dysfunctions in db/db mice were assessed via Morris water maze and novel object discrimination tests. Finally, results were validated in post-mortem sections and protein isolates from individuals with type 2 diabetes. Results Compared with non-diabetic control mice, the db/db mice demonstrated disrupted brain function as revealed by losses in episodic and spatial memory and this occurred concomitantly with dysfunctional NVU, neuronal circuitry and cerebral atrophy. scRNA-seq of db/db mouse cerebral cortex revealed cell population changes in neurons, glia and microglia linked to functional regulatory disruption including neuronal maturation and altered metabolism. These changes were validated through immunohistochemistry and protein expression analysis not just in the db/db mouse cerebral cortex but also in postmortem sections and protein isolates from individuals with type 2 diabetes (74.3 ± 5.5 years) compared with non-diabetic control individuals (87.0 ± 8.5 years). Furthermore, metabolic and synaptic gene disruptions were evident in cortical NVU cell populations and associated with a decrease in vascular density

A survey of cognitive assistants

Cognitive Assistants is a subset area of Personal Assistants focused on ubiquitous and pervasive platforms and services. They are aimed at elderly people’s needs, habits, and emotions by being dynamic, adaptive, sensitive, and responsive. These advances make cognitive assistants a true candidate of being used in real scenarios and help elderly people at home and outside environments. This survey will discuss the cognitive assistants’ emergence in order to provide a list of new projects being developed on this area. We summarize and enumerate the state-of-the-art projects. Moreover, we discuss how technology support the elderly affected by physical or mental disabilities or chronic diseases.Programa Operacional Temático Factores de Competitividade (UID/CEC/00319/2013

Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer

Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key modulators of striatal neuronal function. It has been suggested that the psychostimulant effects of caffeine depend on its ability to block an allosteric modulation within the A2AR-D2R heteromer, by which adenosine decreases the affinity and intrinsic efficacy of dopamine at the D2R. We describe novel unsuspected allosteric mechanisms within the heteromer by which not only A2AR agonists, but also A2AR antagonists, decrease the affinity and intrinsic efficacy of D2R agonists and the affinity of D2R antagonists. Strikingly, these allosteric modulations disappear on agonist and antagonist coadministration. This can be explained by a model that considers A2AR-D2R heteromers as heterotetramers, constituted by A2AR and D2R homodimers, as demonstrated by experiments with bioluminescence resonance energy transfer and bimolecular fluorescence and bioluminescence complementation. As predicted by the model, high concentrations of A2AR antagonists behaved as A2AR agonists and decreased D2R function in the brain

Fulminant Staphylococcus lugdunensis septicaemia following a pelvic varicella-zoster virus infection in an immune-deficient patient: a case report

<p>Abstract</p> <p>Introduction</p> <p>The deadly threat of systemic infections with coagulase negative <it>Staphylococcus lugdunensis </it>despite an appropriate antibiotic therapy has only recently been recognized. The predominant infectious focus observed so far is left-sided native heart valve endocarditis, but bone and soft tissue infections, septicaemia and vascular catheter-related bloodstream infections have also been reported. We present a patient with a fatal <it>Staphylococcus lugdunensis </it>septicaemia following zoster bacterial superinfection of the pelvic region.</p> <p>Case presentation</p> <p>A 71-year old male diagnosed with IgG kappa plasmocytoma presented with a conspicuous weight loss, a hypercalcaemic crisis and acute renal failure. After initiation of haemodialysis treatment his condition improved rapidly. However, he developed a varicella-zoster virus infection of the twelfth thoracic dermatome requiring intravenous acyclovir treatment. Four days later the patient presented with a fulminant septicaemia. Despite an early intravenous antibiotic therapy with ciprofloxacin, piperacillin/combactam and vancomycin the patient died within 48 hours, shortly before the infective isolate was identified as <it>Staphylococcus lugdunensis </it>by polymerase chain reaction.</p> <p>Conclusion</p> <p>Despite <it>S. lugdunensis </it>belonging to the family of coagulase-negative staphylococci with an usually low virulence, infections with <it>S. lugdunensis </it>may be associated with an aggressive course and high mortality. This is the first report on a <it>Staphylococcus lugdunensis </it>septicaemia following a zoster bacterial superinfection of the pelvic region.</p

Seismology of the Sun : Inference of Thermal, Dynamic and Magnetic Field Structures of the Interior

Recent overwhelming evidences show that the sun strongly influences the Earth's climate and environment. Moreover existence of life on this Earth mainly depends upon the sun's energy. Hence, understanding of physics of the sun, especially the thermal, dynamic and magnetic field structures of its interior, is very important. Recently, from the ground and space based observations, it is discovered that sun oscillates near 5 min periodicity in millions of modes. This discovery heralded a new era in solar physics and a separate branch called helioseismology or seismology of the sun has started. Before the advent of helioseismology, sun's thermal structure of the interior was understood from the evolutionary solution of stellar structure equations that mimicked the present age, mass and radius of the sun. Whereas solution of MHD equations yielded internal dynamics and magnetic field structure of the sun's interior. In this presentation, I review the thermal, dynamic and magnetic field structures of the sun's interior as inferred by the helioseismology.Comment: To be published in the proceedings of the meeting "3rd International Conference on Current Developments in Atomic, Molecular, Optical and Nano Physics with Applications", December 14-16, 2011, New Delhi, Indi