The Herschel SPIRE Fourier Transform Spectrometer Spectral Feature Finder I. The Spectral Feature Finder and Catalogue

We provide a detailed description of the Herschel-SPIRE Fourier Transform Spectrometer (FTS) Spectral Feature Finder (FF). The FF is an automated process designed to extract significant spectral features from SPIRE FTS data products. Optimising the number of features found in SPIRE-FTS spectra is challenging. The wide SPIRE-FTS frequency range (447-1568 GHz) leads to many molecular species and atomic fine structure lines falling within the observed bands. As the best spectral resolution of the SPIRE-FTS is ~1.2 GHz, there can be significant line blending, depending on the source type. In order to find, both efficiently and reliably, features in spectra associated with a wide range of sources, the FF iteratively searches for peaks over a number of signal-to-noise ratio (SNR) thresholds. For each threshold, newly identified features are rigorously checked before being added to the fitting model. At the end of each iteration, the FF simultaneously fits the continuum and features found, with the resulting residual spectrum used in the next iteration. The final FF products report the frequency of the features found and the associated SNRs. Line flux determination is not included as part of the FF products, as extracting reliable line flux from SPIRE-FTS data is a complex process that requires careful evaluation and analysis of the spectra on a case-by-case basis. The FF results are 100% complete for features with SNR greater than 10 and 50-70% complete at SNR of 5. The FF code and all FF products are publicly available via the Herschel Science Archive.Comment: 20 pages, 8 figures, 8 tables, final version accepted by MNRAS June 202

High Velocity Impact and Blast Loading of Composite Sandwich Panels with Novel Carbon and Glass Construction

This research investigates whether the layup order of the carbon-fibre/glass-fibre skins in hybrid composite sandwich panels has an effect on impact response. Composite sandwich panels with carbon-fibre/glass-fibre hybrid skins were subjected to impact at velocities of 75 ± 3 and 90 ± 3 m s−1. Measurements of the sandwich panels were made using high-speed 3D digital image correlation (DIC), and post-impact damage was assessed by sectioning the sandwich panels. It was concluded that the introduction of glass-fibre layers into carbon-fibre laminate skins reduces brittle failure compared to a sandwich panel with carbon-fibre reinforced polymer skins alone. Furthermore, if the impact surface is known, it would be beneficial to select an asymmetrical panel such as Hybrid-(GCFGC) utilising glass-fibre layers in compression and carbon-fibre layers in tension. This hybrid sandwich panel achieves a specific deflection of 0.322 mm kg−1 m2 and specific strain of 0.077% kg−1 m2 under an impact velocity of 75 ± 3 m s−1. However, if the impact surface is not known, selection of a panel with a symmetric yet more dispersed hybridisation would be effective. By distributing the different fibre layers more evenly within the skin, less surface and core damage is achieved. The distributed hybrid investigated in this research, Hybrid-(GCGFGCG), achieved a specific deflection of 0.394 mm kg−1 m2 and specific strain of 0.085% kg−1 m2 under an impact velocity of 75 ± 3 m s−1. Blast loading was performed on a large scale version of Hybrid-(GCFGC) and it exhibited a maximum deflection of 75 mm following a similar deflection profile to those observed for the impact experiments

Spt6 is a maintenance factor for centromeric CENP-A

Replication and transcription of genomic DNA requires partial disassembly of nucleosomes to allow progression of polymerases. This presents both an opportunity to remodel the underlying chromatin and a danger of losing epigenetic information. Centromeric transcription is required for stable incorporation of the centromere-specific histone dCENP-A in M/G1 phase, which depends on the eviction of previously deposited H3/H3.3-placeholder nucleosomes. Here we demonstrate that the histone chaperone and transcription elongation factor Spt6 spatially and temporarily coincides with centromeric transcription and prevents the loss of old CENP-A nucleosomes in both Drosophila and human cells. Spt6 binds directly to dCENP-A and dCENP-A mutants carrying phosphomimetic residues alleviate this association. Retention of phosphomimetic dCENP-A mutants is reduced relative to wildtype, while non-phosphorylatable dCENP-A retention is increased and accumulates at the centromere. We conclude that Spt6 acts as a conserved CENP-A maintenance factor that ensures long-term stability of epigenetic centromere identity during transcription-mediated chromatin remodeling

Polo kinase recruitment via the constitutive centromere-associated network at the kinetochore elevates centromeric RNA

The kinetochore, a multi-protein complex assembled on centromeres, is essential to segregate chromosomes during cell division. Deficiencies in kinetochore function can lead to chromosomal instability and aneuploidy-a hallmark of cancer cells. Kinetochore function is controlled by recruitment of regulatory proteins, many of which have been documented, however their function often remains uncharacterized and many are yet to be identified. To identify candidates of kinetochore regulation we used a proteome-wide protein association strategy in budding yeast and detected many proteins that are involved in post-translational modifications such as kinases, phosphatases and histone modifiers. We focused on the Polo-like kinase, Cdc5, and interrogated which cellular components were sensitive to constitutive Cdc5 localization. The kinetochore is particularly sensitive to constitutive Cdc5 kinase activity. Targeting Cdc5 to different kinetochore subcomplexes produced diverse phenotypes, consistent with multiple distinct functions at the kinetochore. We show that targeting Cdc5 to the inner kinetochore, the constitutive centromere-associated network (CCAN), increases the levels of centromeric RNA via an SPT4 dependent mechanism

The ALICE Transition Radiation Detector: Construction, operation, and performance

The Transition Radiation Detector (TRD) was designed and built to enhance the capabilities of the ALICE detector at the Large Hadron Collider (LHC). While aimed at providing electron identification and triggering, the TRD also contributes significantly to the track reconstruction and calibration in the central barrel of ALICE. In this paper the design, construction, operation, and performance of this detector are discussed. A pion rejection factor of up to 410 is achieved at a momentum of 1 GeV/c in p-Pb collisions and the resolution at high transverse momentum improves by about 40% when including the TRD information in track reconstruction. The triggering capability is demonstrated both for jet, light nuclei, and electron selection. (c) 2017 CERN for the benefit of the Authors. Published by Elsevier B.V

Evolution of the longitudinal and azimuthal structure of the near-side jet peak in Pb-Pb collisions at 1asNN = 2.76 TeV

In two-particle angular correlation measurements, jets give rise to a near-side peak, formed by particles associated to a higher-pT trigger particle. Measurements of these correlations as a function of pseudorapidity ( \u3b7) and azimuthal ( \u3c6) differences are used to extract the centrality and pT dependence of the shape of the near-side peak in the pT range 1 < pT < 8 GeV/c in Pb-Pb and pp collisions at 1asNN = 2.76 TeV. A combined fit of the near-side peak and long-range correlations is applied to the data and the peak shape is quantified by the variance of the distributions. While the width of the peak in the \u3c6 direction is almost independent of centrality, a significant broadening in the \u3b7 direction is found from peripheral to central collisions. This feature is prominent for the low-pT region and vanishes above 4 GeV/c. The widths measured in peripheral collisions are equal to those in pp collisions in the \u3c6 direction and above 3 GeV/c in the \u3b7 direction. Furthermore, for the 10% most central collisions and 1 < pT,assoc < 2 GeV/c, 1 < pT,trig < 3 GeV/c, a departure from a Gaussian shape is found: a depletion develops around the center of the peak. The results are compared to A Multi-Phase Transport (AMPT) model simulation as well as other theoretical calculations indicating that the broadening and the development of the depletion are connected to the strength of radial and longitudinal flow

Centrality dependence of inclusive J/\u3c8 production in p-Pb collisions at 1asNN = 5.02 TeV

We present a measurement of inclusive J/\u3c8 production in p-Pb collisions at 1asNN = 5.02TeV as a function of the centrality of the collision, as estimated from the energy deposited in the Zero Degree Calorimeters. The measurement is performed with the ALICE detector down to zero transverse momentum, pT, in the backward ( 124.46 < ycms < 122.96) and forward (2.03 < ycms < 3.53) rapidity intervals in the dimuon decay channel and in the mid-rapidity region ( 121.37 < ycms < 0.43) in the dielectron decay channel. The backward and forward rapidity intervals correspond to the Pb-going and p-going direction, respectively. The pT-differential J/\u3c8 production cross section at backward and forward rapidity is measured for several centrality classes, together with the corresponding average pT and pT2 values. The nuclear modification factor is presented as a function of centrality for the three rapidity intervals, and as a function of pT for several centrality classes at backward and forward rapidity. At mid- and forward rapidity, the J/\u3c8 yield is suppressed up to 40% compared to that in pp interactions scaled by the number of binary collisions. The degree of suppression increases towards central p-Pb collisions at forward rapidity, and with decreasing pT of the J/\u3c8. At backward rapidity, the nuclear modification factor is compatible with unity within the total uncertainties, with an increasing trend from peripheral to central p-Pb collisions

Representaciones de la otredad: experiencia femenina e identidad en ¡Negras somos!

Este trabajo se propone examinar, de forma específica, la literatura colombiana producida por mujeres de ascendencia africana desde la periferia del llamado “canon literario”, y que nosotros definimos como institucionalidad cultural oficial. Para ello, nos apoyaremos en el texto ¡Negras Somos! Antología de 21 mujeres poetas afrocolombianas (2008), una de las primeras colecciones de su género publicada en Colombia y quizás en Latinoamérica, dedicada exclusivamente a la producción cultural de las mujeres escritoras de ascendencia africana. Por un lado, se examinará el discurso lírico como plataforma de recuperación y de construcción de un espacio de expresión personal y colectiva y, por el otro, como medio de afirmación de identidad, pero de una identidad multifacética: femenina, negra y colombiana; en otras palabras, la experiencia de “ser-mujer y negra” dentro de un espacio nacional y de soberanía internacional llamado República de Colombia